The water vapour column density or vertically integrated water vapour (IWV) ranges from about 8 mm in winter to about 25 mm in summer in Bern, Switzerland. However, there can be day episodes when IWV drops to 2 mm or even less so that the atmosphere is extremely dry. We selected an event in February 2021 when the tropospheric water radiometer TROWARA measured a mean IWV value of about 1.5 ± 0.2 mm for a time interval of about one day in Bern. The ECMWF reanalysis ERA5 indicated a slightly higher IWV value of about 2.2 ± 0.4 mm where the uncertainty is the standard deviation of IWV during the time of IWV depression. The ERA5 profiles of relative humidity and specific humidity during this episode are reduced by 50% and more compared to the monthly mean profiles. On a global map, it can be seen that Bern is within a mesoscale dry region on that day with descending wind. Back trajectory analysis gives the result that the dry air masses in Bern came from the North and the trajectories are descending in altitude so that dry air from the mid troposphere came into the lower troposphere. These descending air masses from the North explain the minimum of IWV observed in Bern on 13–14 February 2021. The surface climate in Switzerland was dominated by a cold wave at that time. At the same time, severe cold waves occurred in Greece and Northern America.