“…For example, genomic analysis of the self-incompatibility locus (S-locus) showed that only relict accessions from northern Africa carry all known major haplogroups, suggesting that the selfing ability of A. thaliana evolved in this region from multiple independent inactivation alleles (Tsuchimatsu et al, 2017;Durvasula et al, 2017). Furthermore, some flowering time genes have also revealed differentiation of relict accessions for the frequency of natural polymorphisms affecting gene function, such as a very low frequency of early loss-of-function alleles of FRIGIDA and multiple functional polymorphisms at FLC, FT, FLM, PHYB, PHYC and LHY genes (Mendez-Vigo et al, 2011;Brennan et al, 2014;Liu et al, 2014;Lutz et al, 2017;de Montaigu and Coupland, 2017;James et al, 2018). In addition, other genes have been detected by phenotypic and environmental genome wide-association (GWA) analyses, like the flowering promoters TSF and SOC1, the transcription factors LUG and SLK1 involved in flower development, or the stress regulator EIN2 (The 1001 Genomes Consortium, 2016; Lee et al 2017;Tabas-Madrid et al, 2018).…”