In this paper, the initial-boundary value problem of the 1D full compressible Navier-Stokes equations with positive constant viscosity but with zero heat conductivity is considered. Global well-posedness is established for any H 1 initial data. The initial density is assumed only to be nonnegative, and, thus, is not necessary to be uniformly away from vacuum. Comparing with the well-known result of Kazhikhov-Shelukhin (Kazhikhov, A. V.; Shelukhin, V. V.: Unique global solution with respect to time of initial boundary value problems for one-dimensional equations of a viscous gas, J. Appl. Math. Mech., 41 (1977), 273-282.), the heat conductive coefficient is zero in this paper, and the initial vacuum is allowed. 1 2 JINKAI LIThe compressible Navier-Stokes equations have been extensively studied. In the absence of vacuum, i.e., the case that the density has a uniform positive lower bound, the local well-posedness was proved long time ago by Nash [40], Itaya [18],, Tani [44], Valli [45], and Lukaszewicz [35]; uniqueness was proved even earlier by Graffi [14] and Serrin [43]. Global well-posedness of strong solutions in 1D has been well-known since the works by Kanel [22], and Kazhikhov [23]; global existence and uniqueness of weak solutions was also established, see, e.g., 53], Chen-Hoff-Trivisa [1], and Jiang-Zlotnik [21], and see for the result on the large time behavior. The corresponding global well-posedness results for the multi-dimensional case were established only for small perturbed initial data around some non-vacuum equilibrium or for spherically symmetric large initial data, see, e.g., , Ponce [41], Valli-Zajaczkowski [46], Deckelnick [9], Jiang [19], Hoff [15], Kobayashi-Shibata [25], Danchin [7], Chen-Miao-Zhang [2], Chikami-Danchin [3], Dachin-Xu [8], Fang-Zhang-Zi [10], and the references therein.In the presence of vacuum, that is the density may vanish on some set or tends to zero at the far field, global existence of weak solutions to the isentropic compressible Navier-Stokes equations was first proved by Lions [33,34], with adiabatic constant γ ≥ 9 5 , and later generalized by Feireisl-Novotný-Petzeltová [11] to γ > 3 2 , and further by Jiang-Zhang [20] to γ > 1 for the axisymmetric solutions. For the full compressible Navier-Stokes equations, global existence of the variational weak solutions was proved by Feireisl [12,13], which however is not applicable for the ideal gases. Local wellposedness of strong solutions to the full compressible Navier-Stokes equations, in the presence of vacuum, was proved by Cho-Kim [6], see also Salvi-Straškraba [42], Cho-Choe-Kim [4], and Cho-Kim [5] for the isentropic case. Same to the nonvacuum case, the global well-posedness in 1D also holds for the vacuum case, for arbitrary large initial data, see the recent work by the author [27]. Generally, one can only expect the solutions in the homogeneous Sobolev spaces, see Li-Wang-Xin [26]. Global existence of strong solutions to the multi-dimensional compressible Navier-Stokes equations, with small initial data, ...