Global slowing of network oscillations in mouse neocortex by diazepam

Scheffzük, Claudia; Kukushka, Valeriy I.; Vyssotski, Alexei L.; Draguhn, Andreas; Tort, Adriano Bretanha Lopes; Brankačk, Jurij

doi:10.1016/j.neuropharm.2012.09.014

Cited by 28 publications

(37 citation statements)

References 54 publications

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“…Thus, ketamine‐effects in sedentary humans resemble suppressions in rats emerging specifically during inactivity. Diazepam enhanced beta power as consistently found in rats (Coenen & van Luijtelaar, ; van Lier et al., ; Visser et al., ), mice (Scheffzük et al., ), and cats (Hashimoto, Hamada, Wada, & Fukuda, ).…”

Section: Discussionsupporting

confidence: 54%

Pharmaco‐electroencephalographic responses in the rat differ between active and inactive locomotor states

Hansen

Agerskov

Arvastson

et al. 2019

Eur J of Neuroscience

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Quantitative electroencephalography from freely moving rats is commonly used as a translational tool for predicting drug‐effects in humans. We hypothesized that drug‐effects may be expressed differently depending on whether the rat is in active locomotion or sitting still during recording sessions, and proposed automatic state‐detection as a viable tool for estimating drug‐effects free of hypo‐/hyperlocomotion‐induced effects. We aimed at developing a fully automatic and validated method for detecting two behavioural states: active and inactive, in one‐second intervals and to use the method for evaluating ketamine, DOI, d‐cycloserine, d‐amphetamine, and diazepam effects specifically within each state. The developed state‐detector attained high precision with more than 90% of the detected time correctly classified, and multiple differences between the two detected states were discovered. Ketamine‐induced delta activity was found specifically related to locomotion. Ketamine and DOI suppressed theta and beta oscillations exclusively during inactivity. Characteristic gamma and high‐frequency oscillations (HFO) enhancements of the NMDAR and 5HT 2A modulators, speculated associated with locomotion, were profound and often largest during the inactive state. State‐specific analyses, theoretically eliminating biases from altered occurrence of locomotion, revealed only few effects of d‐amphetamine and diazepam. Overall, drug‐effects were most abundant in the inactive state. In conclusion, this new validated and automatic locomotion state‐detection method enables fast and reliable state‐specific analysis facilitating discovery of state‐dependent drug‐effects and control for altered occurrence of locomotion. This may ultimately lead to better cross‐species translation of electrophysiological effects of pharmacological modulations.

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Section: Discussionsupporting

confidence: 54%

Pharmaco‐electroencephalographic responses in the rat differ between active and inactive locomotor states

Hansen

Agerskov

Arvastson

et al. 2019

Eur J of Neuroscience

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“…Freely moving animals were recorded in 5-h sessions according to the experimental setup depicted in Fig 4A. The frequency distributions displayed typical activity-dependent features as previously described (Tort et al, 2008;Scheffzuk et al, 2013). Freely moving animals were recorded in 5-h sessions according to the experimental setup depicted in Fig 4A. The frequency distributions displayed typical activity-dependent features as previously described (Tort et al, 2008;Scheffzuk et al, 2013).…”

Section: Resultsmentioning

confidence: 79%

Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory

et al. 2017

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Canonical transient receptor potential (TRPC) channels influence various neuronal functions. Using quantitative high-resolution mass spectrometry, we demonstrate that TRPC1, TRPC4, and TRPC5 assemble into heteromultimers with each other, but not with other TRP family members in the mouse brain and hippocampus. In hippocampal neurons from -triple-knockout () mice, lacking any TRPC1-, TRPC4-, or TRPC5-containing channels, action potential-triggered excitatory postsynaptic currents (EPSCs) were significantly reduced, whereas frequency, amplitude, and kinetics of quantal miniature EPSC signaling remained unchanged. Likewise, evoked postsynaptic responses in hippocampal slice recordings and transient potentiation after tetanic stimulation were decreased. , mice displayed impaired cross-frequency coupling in hippocampal networks and deficits in spatial working memory, while spatial reference memory was unaltered. animals also exhibited deficiencies in adapting to a new challenge in a relearning task. Our results indicate the contribution of heteromultimeric channels from TRPC1, TRPC4, and TRPC5 subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons.

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“…It has been consistently demonstrated that theta-gamma coupling increases during REM sleep [39][40][41]46,49,50] ( Figure 3C). This effect is most prominent for the theta modulation of the 110-160-Hz gamma sub-band [40,41,46].…”

Section: Gamma Coupling To Respiration Decreases During Rem Sleep Whmentioning

confidence: 65%

Respiration-Entrained Brain Rhythms Are Global but Often Overlooked

Tort

Brankačk

Draguhn

2018

Trends in Neurosciences

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257

284

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We revisit recent evidence showing that nasal respiration entrains oscillations at the same frequency as breathing in several regions of the rodent brain. Moreover, respiration modulates the amplitude of a specific gamma sub-band (70-120Hz), most prominently in frontal regions. Since rodents often breathe at delta and theta frequencies, we caution that previous studies on delta and theta power and their cross-regional synchrony, as well as on delta-gamma and theta-gamma coupling, may have detected the respiration-entrained rhythm and respiration-gamma coupling. We argue that the simultaneous tracking of respiration along with electrophysiological recordings is necessary to properly identify brain oscillations. We hypothesize that respiration-entrained oscillations aid long-range communication in the brain.

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Global slowing of network oscillations in mouse neocortex by diazepam

Cited by 28 publications

References 54 publications

Pharmaco‐electroencephalographic responses in the rat differ between active and inactive locomotor states

Pharmaco‐electroencephalographic responses in the rat differ between active and inactive locomotor states

Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory

Respiration-Entrained Brain Rhythms Are Global but Often Overlooked

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