Global seroprevalence of Neospora spp. in horses and donkeys: A systematic review and meta-analysis

Javanmardi, Erfan; Majidiani, Hamidreza; Shariatzadeh, Seyyed Ali; Anvari, Davood; Shamsinia, Sadegh; Ghasemi, Ezatollah; Kordi, Bahareh; Shams, Morteza; Asghari, Ali

doi:10.1016/j.vetpar.2020.109299

Cited by 17 publications

(8 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the investigated animal species in this study, the IgG positivity was from 0 (cattle) to 97.3% (donkey), while that of IgM was from 19.5 (cattle) to 91.8% (horse). These findings showed the higher epidemiology of neosporosis in current animals in the QTPA compared with the 5.14, 8.4, 1.9, 23.1, and 9.5% IgG seroprevalence in yaks, Tibetan sheep, pigs, chickens, and equines in several provinces in China (12)(13)(14)(15)(16)(17)(18). Moreover, the N. caninum positivity rates of the present animals were also higher than the 13.46% in equines in the world (17), 40% in pigs in Italy (26), and 3.9% in camels in Iran (27).…”

Section: Discussionmentioning

confidence: 90%

“…These findings showed the higher epidemiology of neosporosis in current animals in the QTPA compared with the 5.14, 8.4, 1.9, 23.1, and 9.5% IgG seroprevalence in yaks, Tibetan sheep, pigs, chickens, and equines in several provinces in China (12)(13)(14)(15)(16)(17)(18). Moreover, the N. caninum positivity rates of the present animals were also higher than the 13.46% in equines in the world (17), 40% in pigs in Italy (26), and 3.9% in camels in Iran (27). Interestingly, the current study found that 97.3% of the donkeys (36/37) and 96.7% of the pigs (441/456) were IgG-positive.…”

Section: Discussionmentioning

confidence: 90%

“…Neospora caninum infection in a large spectrum of wild and domestic animals was described in many countries, especially cattle and dogs (1,3,5,(7)(8)(9)(10)(11). Although the prevalence of neosporosis in various animal hosts has been determined in several areas in China (12)(13)(14)(15)(16)(17)(18), limited data are available on domestic and wild animals exposed to N. caninum in the Qinghai-Tibetan Plateau Area (QTPA). For the epidemiology of neosporosis, serological ELISA diagnostic methods with highly specific and sensitive characteristics have been developed, and ELISAs based on specific antigens derived from N. caninum, especially for the case of surface antigen 1 (NcSAG1) and dense granule protein 7 (NcGRA7), were used to perform serological testing on parasitic infections in a large number of animal samples (19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau

Yang

et al. 2022

Front. Vet. Sci.

View full text Add to dashboard Cite

Neosporosis is a worldwide infectious disease caused by intracellular parasite Neospora caninum that is a major pathogen of abortion in cattle and neurological disorders in other hosts. However, limited data are available on animals exposed to N. caninum in the Qinghai-Tibetan Plateau Area (QTPA), and little is known about whether animals in the plateau area play an important role in the epidemiology of N. caninum. Therefore, indirect ELISAs based on a combination of NcSAG1 and NcGRA7 antigens were developed to examine both N. caninum-specific IgG and IgM antibodies in Tibetan sheep, yak, cow, pig, cattle, horse, chicken, camel, and donkey from the QTPA in this study. The results showed that all current species present- IgG and IgM-positive animals, and that the overall seroprevalence of N. caninum were 18.6 (703/3,782) and 48.1% (1,820/3,782) for the IgG and IgM antibodies, respectively. Further analysis found significant differences from different altitudes in IgG in Tibetan sheep and IgM in the yak. Hence, the present serological results indicate that the tested animal populations in the QTPA are suffering from N. caninum infections or have become carriers of N. caninum antibodies. To the best of our knowledge, this is the first report on current N. caninum-infected animals in the QTPA, the first epidemiology of neosporosis in cow and camel in China, and the first record of N. caninum IgM antibodies in all the surveyed animals in China. This study provides the latest valuable data on the epidemiology of neosporosis in China and in plateau areas of the world.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau

Yang

et al. 2022

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…There is a limit of knowledge on epidemiology, pathology and the zoonotic aspect of Neospora-infection. The overall prevalence of the Neospora infection was estimated 17.14% (95% CI: 15.25-19.10%), 20% (95% CI: 18-21%), and 48.4% (95% CI: 47.5-49.3%) in dogs, cattle, and buffaloes, respectively, and 13.46% (95% CI: 10.26-17.42%) in horses and donkeys in different countries (26)(27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

A Literature Review of Neospora caninum Infection in Humans

Gharekhani¹,

Yakhchali

Keramat

et al. 2021

Avicenna J Clin Microbiol Infect

View full text Add to dashboard Cite

Background: Neosporosis is a parasitic disease caused by Neospora caninum. This parasite is an obligate intracellular coccidia similar to Toxoplasma gondii with a global distribution. With regard to the experimental studies, vertical transmission of the parasite in the monkey (non-human primates) has increased the concern about the zoonotic potential of this disease. The principal aim of the current research was to perform a mini-review on investigations regarding the Neospora infection in humans on a global scale for the first time. Methods: All peer-reviewed articles (published until April 2021) on the Neospora infection in humans were searched in English databases such as Google Scholar, ScienceDirect, Scopus, PubMed, and ProQuest. Results: Based on data in the available articles, the presence of antibodies against the Neospora infection was between 0 and 37.7% in people from different countries. The seroprevalence rate of this infection in HIV-positive individuals was higher (26.6% and 37.7%) compared to other cases. Finally, the genomic DNA of Neospora was detected up to 1% using molecular biology techniques. Conclusions: Overall, the detection of anti-Neospora antibodies in humans indicated that people have been exposed to the parasite. Comprehensive research studies are essential for clarifying the risk factors associated with the Neospora infection in humans. This report provides the baseline information for future researchers. Molecular investigations and genotypic works on N. caninum isolates are highly recommended as well.

show abstract

“…Neosporosis is a parasitic disease caused by an intracellular apicomplexan, Neospora caninum ( N. caninum ) [ 1 ], with serious sequelae such as reproductive failure in livestock species, particularly in cows [ 2 , 3 ]. This protozoan also infects rodents, wild ungulates, birds, and marine mammals [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Determination of B and T Cell Epitopes in Neospora caninum Immune Mapped Protein-1 (IMP-1): Implications in Vaccine Design against Neosporosis

Nazari

Kordi

Maleki

et al. 2022

BioMed Research International

Self Cite

View full text Add to dashboard Cite

Prevention of neosporosis is advantageous for cattle health and productivity. Previously, several vaccine candidates were nominated for vaccination against Neospora caninum. This study was premised on in silico evaluation of N. caninum IMP-1 in order to determine its physicochemical features and immunogenic epitopes. We employed a wide array of network-based tools for the prediction of antigenicity, allergenicity, solubility, posttranslational modification (PTM) sites, physicochemical properties, transmembrane domains and signal peptide, secondary and tertiary structures, and intrinsically disordered regions. Also, prediction and screening of potential continuous B cell peptides and those epitopes having stringent affinity to couple with mouse major histocompatibility complex (MHC) and cytotoxic T lymphocyte (CTL) receptors were accomplished. The protein had 393 residues with a molecular weight of 42.71 kDa, representing aliphatic index of 85.83 (thermotolerant) and GRAVY score of -0.447 (hydrophilic). There were 47 PTM sites without a signal peptide in the sequence. Secondary structure comprised mostly of extended strand and helices, followed by coils. The Ramachandran plot of the refined model showed 90.1%, 9.9%, 0.0%, and 0.0% residues in the favored, additional allowed, generously allowed, and disallowed regions, correspondingly. Additionally, various potential B cell (linear and conformational), CTL, and MHC binding epitopes were predicted for N. caninum IMP-1. The findings of the present study could be further directed for next-generation vaccine design against neosporosis.

show abstract

Global seroprevalence of Neospora spp. in horses and donkeys: A systematic review and meta-analysis

Cited by 17 publications

References 69 publications

Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau

Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau

A Literature Review of Neospora caninum Infection in Humans

Determination of B and T Cell Epitopes in Neospora caninum Immune Mapped Protein-1 (IMP-1): Implications in Vaccine Design against Neosporosis

Contact Info

Product

Resources

About