Global scientific research progress in mycetoma: a bibliometric analysis

Musa, Hassan Hussein; Musa, Taha Hussein; Musa, Ibrahim Hussein; Musa, Idriss Hussein

doi:10.1093/trstmh/trab072

Cited by 10 publications

(7 citation statements)

References 48 publications

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“…Therefore, the actual prevalence and incidence figures are unknown. In 2021, a bibliometric analysis estimated that, in the last 23 years worldwide, only about 20 articles per year have been published about this disease 13 . As a result, studies on the causal agent of actinomycetoma are also scarce.…”

Section: Introductionmentioning

confidence: 99%

Genetic variability of the 16S rRNA gene of Nocardia brasiliensis, the most common causative agent of actinomycetoma in Latin America and the Caribbean

Cruz-Medrano

Manzanares-Leal

González-Nava

et al. 2023

Rev. Inst. Med. trop. S. Paulo

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Mycetoma is a neglected tropical disease (NTD) declared by the World Health Organization (WHO) in 2016. It is characterized by the progressive growth of nodules and granulomatous lesions on the legs, arms, and trunk. It is potentially disfiguring and causes disability or amputations in working-age people from marginalized areas. The causative agents can be fungi (eumycetoma) or actinobacteria (actinomycetoma), the latter being the most common in America and Asia. Nocardia brasiliensis is the most important causal agent of actinomycetoma in the Americas. Taxonomic problems have been reported when identifying this species, so this study aimed to detect the 16S rRNA gene variations in N. brasiliensis strains using an in silico enzymatic restriction technique. The study included strains from clinical cases of actinomycetoma in Mexico, isolated from humans and previously identified as N. brasiliensis by traditional methods. The strains were characterized microscopically and macroscopically, then subjected to DNA extraction and amplification of the 16S rRNA gene by PCR. The amplification products were sequenced, and consensus sequences were constructed and used for genetic identification and in silico restriction enzyme analysis with the New England BioLabs ® NEBcutter program. All study strains were molecularly identified as N. brasiliensis ; however, in silico restriction analysis detected a diversity in the restriction patterns that were finally grouped and subclassified into 7 ribotypes. This finding confirms the existence of subgroups within N. brasiliensis . The results support the need to consider N. brasiliensis as a complex species.

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Section: Introductionmentioning

confidence: 99%

Genetic variability of the 16S rRNA gene of Nocardia brasiliensis, the most common causative agent of actinomycetoma in Latin America and the Caribbean

Cruz-Medrano

Manzanares-Leal

González-Nava

et al. 2023

Rev. Inst. Med. trop. S. Paulo

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“…Furthermore, bibliometric analysis help identifies hot research topics and research gaps in the field. Global, regional, and country-level research on NTDs as a group or as a specific NTD showed an increasing trend [ 26 – 28 ]. In this context, the author did a bibliometric analysis of research publications on NTDs in which at least one author is based in the Arab region to assess the extent of contribution of researchers in the Arab region to the field which can be used for future health planning, research funding, and establishing new research collaborations.…”

Section: Introductionmentioning

confidence: 99%

Contribution of researchers in Arab countries to scientific publications on neglected tropical diseases (1971 – 2020)

Sweileh

2022

Trop Dis Travel Med Vaccines

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Background The neglected tropical diseases (NTDs) are endemic in several Arab countries. The purpose of the current study was to assess the contribution of researchers in Arab countries to the knowledge base on NTDs using bibliometric indicators. Methods Keywords related to all 20 NTDs were obtained from previously published bibliometric studies and were combined with the names of Arab countries listed as country affiliation. the search strategy was implemented in the Scopus database and bibliometric indicators were generated for the study period from 1971 to 2020 Results The search strategy generated 6542 documents; representing less than 4% of the global research in the field. Scientific research on NTDs from researchers in Arab countries (a) has experienced slow growth; (b) generated a relatively inadequate number of publications over the study period; (c) was disseminated mainly through journals in the field of parasitology or tropical medicine; (d) was contributed by researchers from the 22 Arab countries, but mainly by researchers from Egypt, Saudi Arabia, and Sudan; (e) has fragmented author networks with weak collaboration between active authors in the field; (f) was characterized by strong cross-country research collaboration with researchers in the US and the UK; (g) has focused on three main diseases, specifically, schistosomiasis, leishmaniasis, and onchocerciasis, and (h) showed less emphasis on soil-transmitted helminthiasis infections despite high prevalence. Conclusions Arab countries cannot achieve the 2030 global agenda without control and elimination of prevalent NTDs. Researchers in Arab countries need to establish strong research networks to exchange expertise on all NTDs.

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“…The addition of non-steroidal anti inflammatory drugs or oral prednisolone may improve clinical outcomes [4 ▪ ]. Despite an increase in attention to this neglected condition, significant progress needs to be done [10].…”

Section: Introductionmentioning

confidence: 99%

Mycetoma, chromoblastomycosis and other deep fungal infections: diagnostic and treatment approach

Seas

Légua

2022

Current Opinion in Infectious Diseases

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Purpose of review to review recent advances in the epidemiology, diagnosis, and treatment of deep fungal infections Recent findingsMycetoma and chromoblastomycosis are the only deep fungal infections incorporated in the list of neglected tropical diseases. These infections start in the skin but progress to deep tissues if not recognized early. A wide array of fungal pathogens are the causative agents. Molecular methods allow for early and accurate identification of the pathogens, but are unfortunately not available in endemic areas. Treatment options are mostly based upon clinical experience rather than on well-designed clinical trials Summary Deep fungal infections of the skin and soft tissues are rare conditions of wide world distribution but mostly reported from tropical countries. Urgent need for affordable and easily accessible molecular methods and well-conducted studies to allow for accurate diagnosis and to provide evidence to guide proper therapy are urgently needed.

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Global scientific research progress in mycetoma: a bibliometric analysis

Cited by 10 publications

References 48 publications

Genetic variability of the 16S rRNA gene of Nocardia brasiliensis, the most common causative agent of actinomycetoma in Latin America and the Caribbean

Genetic variability of the 16S rRNA gene of Nocardia brasiliensis, the most common causative agent of actinomycetoma in Latin America and the Caribbean

Contribution of researchers in Arab countries to scientific publications on neglected tropical diseases (1971 – 2020)

Mycetoma, chromoblastomycosis and other deep fungal infections: diagnostic and treatment approach

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