Global RNAseq of ocular cells reveals gene dysregulation in both asymptomatic and with Congenital Zika Syndrome infants exposed prenatally to Zika virus

Rosa-Fernandes, Lívia; Bedrat, Amina; Santos, Maria Luiza B Dos; Pinto, Ana M V; Lucena, Evandro; Silva, Thiago Pereira da; Melo, Rossana C. N.; Palmisano, Giuseppe; Cardoso, Claudete Araújo; Barbosa, Raquel Hora

doi:10.1016/j.yexcr.2022.113086

Experimental Cell Research

2022

DOI: 10.1016/j.yexcr.2022.113086

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Global RNAseq of ocular cells reveals gene dysregulation in both asymptomatic and with Congenital Zika Syndrome infants exposed prenatally to Zika virus

Lívia Rosa-Fernandes

Amina Bedrat

Maria Luiza B Dos Santos

et al.

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Cited by 2 publications

References 76 publications

(28 reference statements)

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Machine learning-based gene expression biomarkers to distinguish Zika and Dengue virus infections: implications for diagnosis

Zeba,

Rajalingam,

Sekar

et al. 2024

VirusDis.

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Machine learning-based gene expression biomarkers to distinguish Zika and Dengue virus infections: implications for diagnosis

Zeba,

Rajalingam,

Sekar

et al. 2024

VirusDis.

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Evaluation and monitoring of eye findings in children exposed to Zika virus during gestation: 3 years of follow-up

Dos Santos,

Lima,

Zin

et al. 2023

Journal of Tropical Pediatrics

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Introduction Congenital Zika syndrome (CZS) is a recently described disease. Our main objective was to evaluate and monitor, over 3 years, the ophthalmoscopic findings in children exposed to zika virus (ZIKV) during gestation. Methods This prospective observational study was conducted in Rio de Janeiro, Brazil, between April 2016 and May 2019. We evaluated two groups with exanthema serving as a proxy for viremia: (i) children whose mothers had exanthema during pregnancy and (ii) children who had microcephaly without maternal exanthema during pregnancy. We performed indirect ophthalmoscopy at recruitment and every 6 months thereafter. We also tested the association between ocular findings with maternal exanthema, microcephaly, CZS and maternal infection confirmed by reverse transcriptase quantitative polymerase chain reaction and gender. Results Of the 72 children included, 16 (22.2%) had optic nerve and/or retinal lesions. All 16 had CZS and 15 (93.7%) had microcephaly (14 at birth and 1 postnatally). The child with postnatally acquired microcephaly was born to a mother without exanthema during pregnancy. Fifty-six (77.8%) of the 72 children were followed for a median time of 24 months and none exhibited differences between admission and follow-up examinations. After logistic regression, only microcephaly at birth was associated with eye abnormalities (odds ratio, 77.015; 95% confidence interval, 8.85–670.38; p < 0.001). Conclusion We observed that there was no progression of the lesions over the follow-up period. We also showed that the eye findings were associated only with microcephaly at birth. Attention should be paid to all children born during a ZIKV epidemic, regardless of maternal exanthema and/or microcephaly at birth.

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Global RNAseq of ocular cells reveals gene dysregulation in both asymptomatic and with Congenital Zika Syndrome infants exposed prenatally to Zika virus

Cited by 2 publications

References 76 publications

Machine learning-based gene expression biomarkers to distinguish Zika and Dengue virus infections: implications for diagnosis

Machine learning-based gene expression biomarkers to distinguish Zika and Dengue virus infections: implications for diagnosis

Evaluation and monitoring of eye findings in children exposed to Zika virus during gestation: 3 years of follow-up

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