Global Research Status Regarding Uveitis in the Last Decade

Lu, Ao; Liu, Zhangluxi; Su, Guannan; Yang, Peizeng

doi:10.1080/09273948.2023.2170251

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…Publications and citations of each year, countries, institutions, authors, journals, research domain and H-index were acquired from WoSCC. H-index, as a reference index, indicates the impact of a researcher, country, institution, journal on the development of the certain scientific field ( 29 , 30 ). The WoSCC intrinsic toolkits help to analyze general features mentioned above.…”

Section: Methodsmentioning

confidence: 99%

Global research of artificial intelligence in strabismus: a bibliometric analysis

Zhou,

Zhang,

Tang

et al. 2023

Front. Med.

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PurposeTo analyze the global publications on artificial intelligence (AI) in strabismus using a bibliometric approach.MethodsThe Web of Science Core Collection (WoSCC) database was used to retrieve all of the publications on AI in strabismus from 2002 to 2023. We analyzed the publication and citation trend and identified highly-cited articles, prolific countries, institutions, authors and journals, relevant research domains and keywords. VOSviewer (software) and Bibliometrix (package) were used for data analysis and visualization.ResultsBy analyzing a total of 146 relevant publications, this study found an overall increasing trend in the number of annual publications and citations in the last decade. USA was the most productive country with the closest international cooperation. The top 3 research domains were Ophthalmology, Engineering Biomedical and Optics. Journal of AAPOS was the most productive journal in this field. The keywords analysis showed that “deep learning” and “machine learning” may be the hotspots in the future.ConclusionIn recent years, research on the application of AI in strabismus has made remarkable progress. The future trends will be toward optimized technology and algorithms. Our findings help researchers better understand the development of this field and provide valuable clues for future research directions.

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Section: Methodsmentioning

confidence: 99%

Global research of artificial intelligence in strabismus: a bibliometric analysis

Zhou,

Zhang,

Tang

et al. 2023

Front. Med.

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“…Medications are monoclonal antibodies produced through genetic engineering that can rapidly improve disease and should be administered on the clinical characteristics of the patients [186].…”

Section: Biologicsmentioning

confidence: 99%

Decoding Behcet’s Uveitis: an In-depth review of pathogenesis and therapeutic advances

Guan,

Li,

et al. 2024

J Neuroinflammation

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Behcet’s disease (BD) is a rare but globally distributed vasculitis that primarily affects populations in the Mediterranean and Asian regions. Behcet’s uveitis (BU) is a common manifestation of BD, occurring in over two-thirds of the patients. BU is characterized by bilateral, chronic, recurrent, non-granulomatous uveitis in association with complications such as retinal ischemia and atrophy, optic atrophy, macular ischemia, macular edema, and further neovascular complications (vitreous hemorrhage, neovascular glaucoma). Although the etiology and pathogenesis of BU remain unclear, numerous studies reveal that genetic factors (such as HLA-B51), dysregulated immune responses of both the innate and adaptive immune systems, infections (such as streptococcus), and environmental factors (such as GDP) are all involved in its development. Innate immunity, including hyperactivity of neutrophils and γδT cells and elevated NK1/NK2 ratios, has been shown to play an essential role in this disease. Adaptive immune system disturbance, including homeostatic perturbations, Th1, Th17 overaction, and Treg cell dysfunction, is thought to be involved in BU pathogenesis. Treatment of BU requires a tailored approach based on the location, severity of inflammation, and systemic manifestations. The therapy aims to achieve rapid inflammation suppression, preservation of vision, and prevention of recurrence. Systemic corticosteroids combined with other immunosuppressive agents have been widely used to treat BU, and beneficial effects are observed in most patients. Recently, biologics have been shown to be effective in treating refractory BU cases. Novel therapeutic targets for treating BU include the LCK gene, Th17/Treg balance, JAK pathway inhibition, and cytokines such as IL-17 and RORγt. This article summarizes the recent studies on BU, especially in terms of pathogenesis, diagnostic criteria and classification, auxiliary examination, and treatment options. A better understanding of the significance of microbiome composition, genetic basis, and persistent immune mechanisms, as well as advancements in identifying new biomarkers and implementing objective quantitative detection of BU, may greatly contribute to improving the adequate management of BU patients.

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4-Octyl Itaconate Inhibits Proinflammatory Cytokine Production in Behcet’s Uveitis and Experimental Autoimmune Uveitis

Wang,

Ye,

Tan

et al. 2024

Inflammation

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Global Research Status Regarding Uveitis in the Last Decade

Cited by 5 publications

References 33 publications

Global research of artificial intelligence in strabismus: a bibliometric analysis

Global research of artificial intelligence in strabismus: a bibliometric analysis

Decoding Behcet’s Uveitis: an In-depth review of pathogenesis and therapeutic advances

4-Octyl Itaconate Inhibits Proinflammatory Cytokine Production in Behcet’s Uveitis and Experimental Autoimmune Uveitis

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