Global research profile on monkeypox-related literature (1962–2022): A bibliometric analysis

Sofyantoro, Fajar; Kusuma, Hendrix Indra; Vento, Sandro; Rademaker, Marius; Frediansyah, Andri

doi:10.52225/narra.v2i3.96

Cited by 9 publications

(4 citation statements)

References 62 publications

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“…Currently, Tecovirimat, which acts through intervening with the viral envelop protein, 63 is the only European Medicines Agency (EMA)‐approved antiviral for the treatment of smallpox, cowpox, Mpox, and vaccinia complications. Interestingly, exploring topics in a bibliometric analysis of the literature on MPXV has recently revealed that Tecovirimat remains the most‐investigated topic 64 . However, Cidofovir and Brincidofovir could also be efficacious against Mpox, but the scarcity of clinical trials is prohibiting the approval of these drugs for pox‐like infections in humans 5 .…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, exploring topics in a bibliometric analysis of the literature on MPXV has recently revealed that Tecovirimat remains the most-investigated topic. 64 However, Cidofovir and Brincidofovir could also be efficacious against Mpox, but the scarcity of clinical trials is prohibiting the approval of these drugs for pox-like infections in humans. 5 By highlighting the above remarks, this review can draw implications for developing specific immunotherapeutics.…”

Section: Discussionmentioning

confidence: 99%

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Insights on Mpox virus infection immunopathogenesis

Saghazadeh

Rezaei

2023

Reviews in Medical Virology

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An immunocompromised status has been associated with more odds of being infected with Mpox virus (MPXV) and progressing to severe disease. This aligns with the importance of immune competence for MPXV control and clearance. We and others have previously reviewed parallels between MPXV and other viruses belonging to the Poxviridae in affecting the immune system. This article reviews studies providing direct evidence of the MPXV-immune interactions. The wideranging effects of MPXV on the immune system, from stimulation to modulation to memory, are broadly categorised, followed by a detailing of these effects on the immune cells and molecules, including natural killer cells, macrophages, neutrophils, lymphocytes, cytokines, interferons, chemokines, and complement. K E Y W O R D Simmune system, Mpox virus, MPXV | INTRODUCTIONAfter about 80 years of its presence in endemic regions, the Mpox virus (MPXV) will be a cause of the outbreak in non-endemic regions in 2022. 1 From May 2022, when the MPXV outbreak occurred, until 23 December 2022, when writing this piece, more than 83,000 cases have been reported to the CDC, with 72 deaths corresponding to the death rate of about 0.09%. 2 However, since 1970 when MPXV first occurred in humans, the cumulative death rate has been calculated at about 11%. Also, mortality remains higher in Africa; according to the last weekly report of the World Health Organization (WHO), the case fatality rate (CFR) of MPXV was estimated at about 2% for the week of 29 August-4 September 2022, in multiple African countries. 3 Totally, high MPXV transmission, despite its globally low mortality rate in the 2022 outbreak, has warned researchers and practitioners that it is time for implementation, while they had just begun learning lessons on the coronavirus disease (COVID-19) pandemic.As expected, 2022 has subsequently witnessed a surge in MPXV literature. Because it takes late for original research to be planned, conducted, and released, many efforts took place to review the current knowledge of MPX-related features in history, epidemiology, and clinical infection, as reviewed elsewhere. 4,5 They led to important messages. MPXV, previously isolated in endemic regions, is of two clades: clade I, Central African, also known as Congo Basin; clade II, West African, which, in turn, has two clades: IIa and IIb. Clade I is endemic in the Democratic Republic of the Congo (DRC) and South Sudan, with a fatality rate of about 11%. MPXV we today are experiencing is of the West African clade IIb. This clade is endemic in Nigeria and associated with a CFR of about 4%. However, compared to previous times, 2022 0 MPXV has been different in its presentation.Meta-analysis confirms this changing epidemiology that between

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Insights on Mpox virus infection immunopathogenesis

Saghazadeh

Rezaei

2023

Reviews in Medical Virology

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“…In this study, the Scopus database served as our sole data source because it covered a large range of journals and a high number of articles relative to other libraries such as Web of Science or PubMed [93,94]. Scopus has also been validated and recognized in other bibliometric analyses [75,79,[95][96][97]. Data extraction was performed on December 17, 2022.…”

Section: Methodsmentioning

confidence: 99%

Growth in chikungunya virus-related research in ASEAN and South Asian countries from 1967 to 2022 following disease emergence: a bibliometric and graphical analysis

et al. 2023

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Background ASEAN (Association of Southeast Asian Nations) is composed of ten Southeast Asian countries bound by socio-cultural ties that promote regional peace and stability. South Asia, located in the southern subregion of Asia, includes nine countries sharing similarities in geographical and ethno-cultural factors. Chikungunya is one of the most significant problems in Southeast and South Asian countries. Much of the current chikungunya epidemic in Southeast Asia is caused by the emergence of a virus strain that originated in Africa and spread to Southeast Asia. Meanwhile, in South Asia, three confirmed lineages are in circulation. Given the positive correlation between research activity and the improvement of the clinical framework of biomedical research, this article aimed to examine the growth of chikungunya virus-related research in ASEAN and South Asian countries. Methods The Scopus database was used for this bibliometric analysis. The retrieved publications were subjected to a number of analyses, including those for the most prolific countries, journals, authors, institutions, and articles. Co-occurrence mapping of terms and keywords was used to determine the current state, emerging topics, and future prospects of chikungunya virus-related research. Bibliometrix and VOSviewer were used to analyze the data and visualize the collaboration network mapping. Results The Scopus search engine identified 1280 chikungunya-related documents published by ASEAN and South Asian countries between 1967 and 2022. According to our findings, India was the most productive country in South Asia, and Thailand was the most productive country in Southeast Asia. In the early stages of the study, researchers investigated the vectors and outbreaks of the chikungunya virus. In recent years, the development of antivirus agents has emerged as a prominent topic. Conclusions Our study is the first to present the growth of chikungunya virus-related research in ASEAN and South Asian countries from 1967 to 2022. In this study, the evaluation of the comprehensive profile of research on chikungunya can serve as a guide for future studies. In addition, a bibliometric analysis may serve as a resource for healthcare policymakers.

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“…The rising incidences of human mpox highlights the need for vigilant surveillance for the disease, prompt diagnosis, and developing effective vaccines, drugs, and treatment options [ 19 , 20 , 21 ]. Primary prevention of mpox is achieved by public awareness campaigns that highlight the risk factors for the disease and the preventative steps that can be taken to lessen those risks [ 15 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitude and Worry in the Kurdistan Region of Iraq during the Mpox (Monkeypox) Outbreak in 2022: An Online Cross-Sectional Study

et al. 2023

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The rapid spread of monkeypox (mpox) has been declared as a public health emergency of international concern (PHEIC). The present study aimed to assess the knowledge, attitude, and worry levels of the general population in the Kurdistan region of Iraq regarding the ongoing mpox multi-country outbreak. An online cross-sectional survey was conducted between 27–30 July 2022, using a convenience sampling method. The questionnaire was adapted from previous studies addressing the same topic. The independent Student’s t-test, one-way ANOVA, and logistic regression were used to assess possible factors associated with knowledge, attitude, and worry toward mpox. A total of 510 respondents were included in the final analysis. The participants showed a moderate level of mpox knowledge, a neutral attitude towards mpox, and a relatively moderate worry level. The logistic regression analysis showed that age, gender, marital status, religion, level of education, and place of residence were associated with mpox knowledge; however, the significant variables in the multivariate regression analysis were gender, religion, level of education, and residential area. Gender and residential area were associated with attitudes toward mpox; however, the significant variables in the multivariate regression analysis were gender and residential areas. The worry toward mpox was influenced by gender, marital status, religion, and place of residence, yet the significant variables in the multivariate regression analysis were gender, religion, educational level, and residential area. In conclusion, the Kurdish population had moderate knowledge, a neutral attitude, and a moderate level of worry about mpox. Considering the continuous rapid rise in mpox cases in several countries, and its possible risk as pandemic amid the ongoing COVID-19 pandemic, proactive control measures, adequate disease prevention strategies, and preparedness plans need to be formulated and immediately implemented to tackle the appearance of fears among people, and to safeguard the mental health of the public.

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Global research profile on monkeypox-related literature (1962–2022): A bibliometric analysis

Cited by 9 publications

References 62 publications

Insights on Mpox virus infection immunopathogenesis

Insights on Mpox virus infection immunopathogenesis

Growth in chikungunya virus-related research in ASEAN and South Asian countries from 1967 to 2022 following disease emergence: a bibliometric and graphical analysis

Knowledge, Attitude and Worry in the Kurdistan Region of Iraq during the Mpox (Monkeypox) Outbreak in 2022: An Online Cross-Sectional Study

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