“…": Further those drugs of the group possessing activity against serotonin which have been shown to be effective in urticaria-for example, cryoheptadine and azatadine-may not be acting because of this effect alone; firstly, as the role of serotonin in the aetiology of urticaria is not clear and secondly because most anti-serotonin drugs also have HI antihistamine activity. 3 Recently the discovery by Black et al 1972, 8 Marks and Greaves 1977 9 that dermal blood vessels possess both HI and H 2 receptors has stimulated the assessment of combination (HI antihistamine together with an H 2 blocking agent) therapy in chronic urticaria and dermographism.…”