Global regulations and legislations on nanoparticles usage and application in diverse horizons

Mishra, Ajay Kumar; Das, Rajeswari; Sahoo, Sanket; Biswal, Bisworanjita

doi:10.1016/bs.coac.2021.12.004

Cited by 4 publications

(2 citation statements)

References 101 publications

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“…Soft NPs made of polymers and liposomes have gained regulatory permission for clinical use and have demonstrated promise in nanomedicine. 185 In contrast to their use as therapeutic agents, NPs are mostly studied as delivery agents, and the effects of NPs on biological systems after administration and their removal still need to be thoroughly studied. 186 Before NPs are used in clinical settings, it is important to study several preclinical and clinical trial design problems such as immediate and long-term stability, tolerability, biodistribution, and elimination of NPs.…”

Section: Aspects Of Nanomaterials and Nano Therapies’ Biosafetymentioning

confidence: 99%

How Precise are Nanomedicines in Overcoming the Blood–Brain Barrier? A Comprehensive Review of the Literature

Mohapatra,

Gopikrishnan,

Doss C

et al. 2024

IJN

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New nanotechnology strategies for enhancing drug delivery in brain disorders have recently received increasing attention from drug designers. The treatment of neurological conditions, including brain tumors, stroke, Parkinson’s Disease (PD), and Alzheimer’s disease (AD), may be greatly influenced by nanotechnology. Numerous studies on neurodegeneration have demonstrated the effective application of nanomaterials in the treatment of brain illnesses. Nanocarriers (NCs) have made it easier to deliver drugs precisely to where they are needed. Thus, the most effective use of nanomaterials is in the treatment of various brain diseases, as this amplifies the overall impact of medication and emphasizes the significance of nanotherapeutics through gene therapy, enzyme replacement therapy, and blood-barrier mechanisms. Recent advances in nanotechnology have led to the development of multifunctional nanotherapeutic agents, a promising treatment for brain disorders. This novel method reduces the side effects and improves treatment outcomes. This review critically assesses efficient nano-based systems in light of obstacles and outstanding achievements. Nanocarriers that transfer medications across the blood-brain barrier and nano-assisted therapies, including nano-immunotherapy, nano-gene therapy, nano enzyme replacement therapy, scaffolds, and 3D to 6D printing, have been widely explored for the treatment of brain disorders. This study aimed to evaluate existing literature regarding the use of nanotechnology in the development of drug delivery systems that can penetrate the blood-brain barrier (BBB) and deliver therapeutic agents to treat various brain disorders.

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Section: Aspects Of Nanomaterials and Nano Therapies’ Biosafetymentioning

confidence: 99%

How Precise are Nanomedicines in Overcoming the Blood–Brain Barrier? A Comprehensive Review of the Literature

Mohapatra,

Gopikrishnan,

Doss C

et al. 2024

IJN

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“…However, when it comes to sodic soil, due to excess sodium ion (Na + ) deposition in the soil matrix, the deflocculation of soil particles leads to disturbance in the soil structure and aggregate stability. As a result, a reduced macroporosity is responsible for infiltration, and drainage further aggravates the unavailability of water and nutrients for stress-affected plants (Singh et al, 2016;Mishra et al, 2018a). Salinity, when it persists, gradually reduces the water influx into the vascular bundles present in plant's roots, making the cells flaccid, and the plant gradually suffers from physiological drought.…”

Section: Soil Salinity Affecting Crop Sustainability: a Call For Adva...mentioning

confidence: 99%

Promising management strategies to improve crop sustainability and to amend soil salinity

Mishra

Das²,

Kerry³

et al. 2023

Front. Environ. Sci.

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By affecting 10% of the world’s total arable land, soil salinity has become a potential threat to feeding the exploding population. As per the current scenario, among 1,125 million hectares of salt-affected land, nearly 76 million hectares are seriously affected due to human-induced salinization. Due to soil salinization, crop productivity is being hampered. In order to enhance productivity, there is an urgent need to shift from traditional methods to advanced 3E (efficient, economic, and environmentally sound) technology for soil salinity reclamation and management to achieve better soil health and sustainable crop production. The detailed mechanism of salt interference with various pathways involved in plant growth and development needs to be understood. This article critically reviews the mechanism of harmful salt interference with nutrient dynamics in soil and various physiological pathways involved in crop growth to apply various soil-oriented (crop residue management, biochar application, and agroforestry system) and plant-oriented [plant growth-promoting microbes (PGPMs), plant growth regulators, and nanotechnology] promising reclamation and rehabilitation approaches to mitigate its hazardous effect on soil salinity. The monitoring and assessment of salt-affected soils through remote sensing (RS) and geographical information systems (GISs) are pivotal in the management and framing of long-term policies to confront alarming threats to crop productivity and sustainability. This study provides an insight into recent developments in soil salinity management and proposes futuristic solutions that could ameliorate soil salinity to attain crop sustainability under adverse environmental conditions.

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Regulatory Pathways for Nanocarrier Vaccine

Gogoi,

Bezbaruah,

Patel

et al. 2024

Nanocarrier Vaccines

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Global regulations and legislations on nanoparticles usage and application in diverse horizons

Cited by 4 publications

References 101 publications

How Precise are Nanomedicines in Overcoming the Blood–Brain Barrier? A Comprehensive Review of the Literature

How Precise are Nanomedicines in Overcoming the Blood–Brain Barrier? A Comprehensive Review of the Literature

Promising management strategies to improve crop sustainability and to amend soil salinity

Regulatory Pathways for Nanocarrier Vaccine

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