Global, regional, and national cancer incidence and death for 29 cancer groups in 2019 and trends analysis of the global cancer burden, 1990–2019

Lin, Liwu; Li, Zhiyong; Yan, Lei; Liu, Yuling; Yang, Hongjun; Li, Hui

doi:10.1186/s13045-021-01213-z

Cited by 184 publications

(141 citation statements)

References 69 publications

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“…They posit that occupational exposures may be causing these relationships in men. Since 1990, the number of people dying from cancer has doubled, rising to 10 million across the globe [ 84 ]. In 2019, Western Europe had one of the highest number of cancer deaths across the globe (1.27 million) and the highest incidences along with North America and East Asia.…”

Section: Discussionmentioning

confidence: 99%

Is Population Density Associated with Non-Communicable Disease in Western Developed Countries? A Systematic Review

Inglis

Taylor

Bak-Klimek

et al. 2022

IJERPH

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Over the last three decades, researchers have investigated population density and health outcomes at differing scale. There has not been a systematic review conducted in order to synthesise this evidence. Following the Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines, we systematically reviewed quantitative evidence published since 1990 on population density and non-communicable disease (NCD) within Westernised countries. Fifty-four studies met the inclusion criteria and were evaluated utilising a quality assessment tool for ecological studies. High population density appears to be associated with higher mortality rates of a range of cancers, cardiovascular disease and COPD, and a higher incidence of a range of cancers, asthma and club foot. In contrast, diabetes incidence was found to be associated with low population density. High and low population density are therefore risk markers for a range of NCDs, indicating that there are unidentified factors and mechanisms underlying aetiology. On closer examination, our synthesis revealed important and complex relationships between population density, the built environment, the nature of greenspace and man-made exposures. In light of increasing rates of morbidity and mortality, future research is required to investigate these associations in order to establish causative agents for each NCD.

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Section: Discussionmentioning

confidence: 99%

Is Population Density Associated with Non-Communicable Disease in Western Developed Countries? A Systematic Review

Inglis

Taylor

Bak-Klimek

et al. 2022

IJERPH

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show abstract

“…Cancer is a serious chronic disease which becomes the key causes of death and disability in the world. An analysis of the global burden of cancer 1990–2019 showed that more than 10 million people died of cancer in 2019, roughly double the number in 1990 ( Lin et al, 2021 ). Using data updated in 2020 from the International Agency for Research on Cancer, it is estimated that there are 19.3 million new cancer cases and nearly 10 million cancer patients’ death worldwide in 2020 ( Sung et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

ACSL4 as a Potential Target and Biomarker for Anticancer: From Molecular Mechanisms to Clinical Therapeutics

Hou

Jiang²,

Wen³

et al. 2022

Front. Pharmacol.

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Cancer is a major public health problem around the world and the key leading cause of death in the world. It is well-known that glucolipid metabolism, immunoreaction, and growth/death pattern of cancer cells are markedly different from normal cells. Recently, acyl-CoA synthetase long-chain family 4 (ACSL4) is found be participated in the activation of long chain fatty acids metabolism, immune signaling transduction, and ferroptosis, which can be a promising potential target and biomarker for anticancer. Specifically, ACSL4 inhibits the progress of lung cancer, estrogen receptor (ER) positive breast cancer, cervical cancer and the up-regulation of ACSL4 can improve the sensitivity of cancer cells to ferroptosis by enhancing the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS). However, it is undeniable that the high expression of ACSL4 in ER negative breast cancer, hepatocellular carcinoma, colorectal cancer, and prostate cancer can also be related with tumor cell proliferation, migration, and invasion. In the present review, we provide an update on understanding the controversial roles of ACSL4 in different cancer cells.

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“…CM arises from the malignant transformation of melanocytes found in the skin epidermis, which produce the photoprotective pigment melanin and are also involved in ROS/RNS scavenging, thermoregulation and immunomodulation ( 2 – 4 ). Even though it only represents 5% of all types of skin neoplasms, CM is considered the most lethal, being responsible for 60-75% of skin cancer-related deaths ( 5 – 7 ). From 1990 to 2019, incident cases of CM have increased by 170% worldwide, faster than most neoplasms, mainly due to a rapidly aging population, changes in lifestyle and better screening ( 8 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

The Dark Side of Melanin Secretion in Cutaneous Melanoma Aggressiveness

Cabaço

Tomás²,

Pojo³

et al. 2022

Front. Oncol.

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Skin cancers are among the most common cancers worldwide and are increasingly prevalent. Cutaneous melanoma (CM) is characterized by the malignant transformation of melanocytes in the epidermis. Although CM shows lower incidence than other skin cancers, it is the most aggressive and responsible for the vast majority of skin cancer-related deaths. Indeed, 75% of patients present with invasive or metastatic tumors, even after surgical excision. In CM, the photoprotective pigment melanin, which is produced by melanocytes, plays a central role in the pathology of the disease. Melanin absorbs ultraviolet radiation and scavenges reactive oxygen/nitrogen species (ROS/RNS) resulting from the radiation exposure. However, the scavenged ROS/RNS modify melanin and lead to the induction of signature DNA damage in CM cells, namely cyclobutane pyrimidine dimers, which are known to promote CM immortalization and carcinogenesis. Despite triggering the malignant transformation of melanocytes and promoting initial tumor growth, the presence of melanin inside CM cells is described to negatively regulate their invasiveness by increasing cell stiffness and reducing elasticity. Emerging evidence also indicates that melanin secreted from CM cells is required for the immunomodulation of tumor microenvironment. Indeed, melanin transforms dermal fibroblasts in cancer-associated fibroblasts, suppresses the immune system and promotes tumor angiogenesis, thus sustaining CM progression and metastasis. Here, we review the current knowledge on the role of melanin secretion in CM aggressiveness and the molecular machinery involved, as well as the impact in tumor microenvironment and immune responses. A better understanding of this role and the molecular players involved could enable the modulation of melanin secretion to become a therapeutic strategy to impair CM invasion and metastasis and, hence, reduce the burden of CM-associated deaths.

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Global, regional, and national cancer incidence and death for 29 cancer groups in 2019 and trends analysis of the global cancer burden, 1990–2019

Cited by 184 publications

References 69 publications

Is Population Density Associated with Non-Communicable Disease in Western Developed Countries? A Systematic Review

Is Population Density Associated with Non-Communicable Disease in Western Developed Countries? A Systematic Review

ACSL4 as a Potential Target and Biomarker for Anticancer: From Molecular Mechanisms to Clinical Therapeutics

The Dark Side of Melanin Secretion in Cutaneous Melanoma Aggressiveness

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