Global, regional, and national burden and attributable risk factors of neurological disorders: The Global Burden of Disease study 1990–2019

Ding, Chenyu; Wu, Yuying; Chen, Yue; Wu, Zanyi; Lin, Zhangya; Kang, Dezhi; Fang, Wenhua; Chen, Fa

doi:10.3389/fpubh.2022.952161

Cited by 117 publications

(80 citation statements)

References 19 publications

(27 reference statements)

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“…With a continually increasing disease burden of nearly 10 million patients worldwide [ 1 ], Parkinson’s disease (PD) is a devastating neurodegenerative disorder that is characterized by the loss of multiple neuronal populations and the aggregation of α-synuclein protein into intracellular inclusions known as Lewy bodies (LBs) [ 2 , 3 ]. The progressive death of dopaminergic neurons in the substantia nigra leads to a depletion of dopamine signaling in the striatum that manifests as classic Parkinsonian symptoms, such as bradykinesia, rigidity, and resting tremors which worsen over time [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Gut-to-Brain α-Synuclein Transmission in Parkinson’s Disease: Evidence for Prion-like Mechanisms

Chen

Mor

2023

IJMS

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Parkinson’s disease (PD) is a multifactorial disorder involving both motor and non-motor symptoms caused by the progressive death of distinct neuronal populations, including dopaminergic neurons in the substantia nigra. The deposition of aggregated α-synuclein protein into Lewy body inclusions is a hallmark of the disorder, and α-synuclein pathology has been found in the enteric nervous system (ENS) of PD patients up to two decades prior to diagnosis. In combination with the high occurrence of gastrointestinal dysfunction in early stages of PD, current evidence strongly suggests that some forms of PD may originate in the gut. In this review, we discuss human studies that support ENS Lewy pathology as a characteristic feature of PD, and present evidence from humans and animal model systems that α-synuclein aggregation may follow a prion-like spreading cascade from enteric neurons, through the vagal nerve, and into the brain. Given the accessibility of the human gut to pharmacologic and dietary interventions, therapeutic strategies aimed at reducing pathological α-synuclein in the gastrointestinal tract hold significant promise for PD treatment.

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Section: Introductionmentioning

confidence: 99%

Gut-to-Brain α-Synuclein Transmission in Parkinson’s Disease: Evidence for Prion-like Mechanisms

Chen

Mor

2023

IJMS

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“…Ischaemic stroke is the leading cause of disability worldwide and a leading cause of death [ 1 ]. Long-term disability and/or death is most often caused by a large cerebral vessel occlusion (LVO).…”

Section: Introductionmentioning

confidence: 99%

World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention

Grunwald¹,

Mathias²,

Bertog³

et al. 2023

pwki

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Introduction: Today, endovascular treatment (EVT) is the therapy of choice for strokes due to acute large vessel occlusion, irrespective of prior thrombolysis. This necessitates fast, coordinated multi-specialty collaboration. Currently, in most countries, the number of physicians and centres with expertise in EVT is limited. Thus, only a small proportion of eligible patients receive this potentially life-saving therapy, often after significant delays. Hence, there is an unmet need to train a sufficient number of physicians and centres in acute stroke intervention in order to allow widespread and timely access to EVT.Aim: To provide multi-specialty training guidelines for competency, accreditation and certification of centres and physicians in EVT for acute large vessel occlusion strokes.Material and methods: The World Federation for Interventional Stroke Treatment (WIST) consists of experts in the field of endovascular stroke treatment. This interdisciplinary working group developed competency -rather than time-based -guidelines for operator training, taking into consideration trainees' previous skillsets and experience. Existing training concepts from mostly single specialty organizations were analysed and incorporated.Results: The WIST establishes an individualized approach to acquiring clinical knowledge and procedural skills to meet the competency requirements for certification of interventionalists of various disciplines and stroke centres in EVT. WIST guidelines encourage acquisition of skills using innovative training methods such as structured supervised high-fidelity simulation and procedural performance on human perfused cadaveric models.Conclusions: WIST multispecialty guidelines outline competency and quality standards for physicians and centres to perform safe and effective EVT. The role of quality control and quality assurance is highlighted.

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“…Stroke, which was first referred to as "apoplexy" by William Cole in 1689, has become a significant cause of mortality and disability, particularly among the aging population worldwide [1][2][3][4]. It is defined as an acute onset of focal neurologic deficit caused by a cerebral blood circulation disorder that lasts for more than 24 hours or causes death with no other cause than of vascular origin and is also known as cerebrovascular accident (CVA) [5][6][7].…”

Section: Introduction and Background Introductionmentioning

confidence: 99%

Virtual and Augmented Reality in Post-stroke Rehabilitation: A Narrative Review

Khokale¹,

Mathew²,

Ahmed³

et al. 2023

Cureus

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Virtual reality (VR) and augmented reality (AR) are noble adjunctive technologies currently being studied for the neuro-rehabilitation of post-stroke patients, potentially enhancing conventional therapy. We explored the literature to find if VR/AR improves neuroplasticity in stroke rehabilitation for a better quality of life. This modality can lay the foundation for telerehabilitation services in remote areas. We analyzed four databases, namely Cochrane Library, PubMed, Google Scholar, and Science Direct, by searching the following keywords: ("Stroke Rehabilitation" [Majr]) AND ("Augmented Reality" [Majr]), Virtual Augmented Reality in Stroke Rehabilitation. All the available open articles were reviewed and outlined. The studies conclude that VR/AR can help in early rehabilitation and yield better results in post-stroke patients in adjunct to conventional therapy. However, due to the limited research on this subject, we cannot conclude that this information is absolute. Moreover, VR/AR was seldom customized according to the needs of stroke survivors, which would have given us the full extent of its application. Around the world, stroke survivors are being studied to verify the accessibility and practicality of these innovative technologies. Observations conclude that further exploration of the extent of the implementations and efficacy of VR and AR, combined with conventional rehabilitation, is fundamental.

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Global, regional, and national burden and attributable risk factors of neurological disorders: The Global Burden of Disease study 1990–2019

Cited by 117 publications

References 19 publications

Gut-to-Brain α-Synuclein Transmission in Parkinson’s Disease: Evidence for Prion-like Mechanisms

Gut-to-Brain α-Synuclein Transmission in Parkinson’s Disease: Evidence for Prion-like Mechanisms

World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention

Virtual and Augmented Reality in Post-stroke Rehabilitation: A Narrative Review

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