Global, Regional, and National Burden of Low Back Pain, 1990–2020, Its Attributable Risk Factors, And Projections to 2050: A Systematic Analysis of the Global Burden of Disease Study 2021

Ferreira, Manuela L; Luca, Katie de; Haile, Lydia; Steinmetz, Jaimie D; Culbreth, Garland; Cross, Marita; Kopeć, Jacek A.; Ferreira, Paulo Henrique da Cruz; Blyth, Fiona; Buchbinder, Rachelle; Hartvigsen, Jan; Wu, Aoli; Safiri, Saeid; Woolf, Anthony D.; Collins, Gary S.; Vollset, Stein Emil; Smith, Amanda L.; Cruz, Jéssica Reco; Fututaki, Kai; Vos, Theo; March, Lyn

doi:10.2139/ssrn.4318392

Cited by 51 publications

(49 citation statements)

References 11 publications

(15 reference statements)

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“…Strine and Hootman previously estimated the 3-month US prevalence of neck pain and low back pain at 9.3% [ 12 ], while in this study, we estimated the 3-month prevalence of spinal pain at 12.3%. The most recent Global Burden of Disease study estimates reveal a significant increase in the number of prevalent cases of low back pain globally since 1990 (60.4%), with projections suggesting that in 2050, there will be 843 million prevalent cases of low back pain globally [ 2 ]. The 2018 Lancet low back pain series highlighted the roles of advice and education that support self-management, physical, and psychological interventions, especially as first-line treatments for low back pain [ 21 , 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Low back and neck pain (spinal pain) are considered the leading causes of years lived with disability in most countries and age groups [ 1 ]. In the 2021 Global Burden of Disease study, low back pain continues to be the greatest cause of disability burden worldwide, with 12.5% and 11.5% of years lived with disability due to low back pain attributed to modifiable risk factors smoking and elevated body mass index, respectively [ 2 ]. In adults aged 50 years and over, low back pain, ischemic heart disease and diabetes were all ranked in the top ten causes of disability adjusted life years globally [ 3 ], with ischemic heart disease and diabetes both in the top ten causes of death globally (1st and 10th, respectively).…”

Section: Introductionmentioning

confidence: 99%

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Spinal Pain, Chronic Health Conditions and Health Behaviors: Data from the 2016–2018 National Health Interview Survey

Luca

Tavares

Yang

et al. 2023

IJERPH

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Spinal pain and chronic health conditions are highly prevalent, burdensome, and costly conditions, both in the United States and globally. Using cross-sectional data from the 2016 through 2018 National Health Interview Survey (n = 26,926), we explored associations between spinal pain and chronic health conditions and investigated the influence that a set of confounders may have on the associations between spinal pain and chronic health conditions. Variance estimation method was used to compute weighted descriptive statistics and measures of associations with multinomial logistic regression models. All four chronic health conditions significantly increased the prevalence odds of spinal pain; cardiovascular conditions by 58%, hypertension by 40%, diabetes by 25% and obesity by 34%, controlling for all the confounders. For all chronic health conditions, tobacco use (45–50%), being insufficiently active (17–20%), sleep problems (180–184%), cognitive impairment (90–100%), and mental health conditions (68–80%) significantly increased the prevalence odds of spinal pain compared to cases without spinal pain. These findings provide evidence to support research on the prevention and treatment of non-musculoskeletal conditions with approaches of spinal pain management.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spinal Pain, Chronic Health Conditions and Health Behaviors: Data from the 2016–2018 National Health Interview Survey

Luca

Tavares

Yang

et al. 2023

IJERPH

Self Cite

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“…Back pain (BP) and neck pain (NP), often referred to collectively as spinal pain (Ferreira & de Luca, 2017), are also regarded as a serious public health concern, affecting 610 million people globally in 2020 and projected to reach 843 million by 2050 (Ferreira et al., 2023). Acknowledged as the primary cause of years lived with disability worldwide (Hartvigsen et al., 2018), spinal pain often co‐exists with cognitive decline and neurodegeneration (Ferreira & de Luca, 2017; Williams et al., 2018), contributing to reduced functional capacity and lower overall quality of life (Bailey et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

Cognition is selectively impaired in males with spinal pain: A retrospective analysis of data from the Longitudinal Study of Ageing Danish Twins

Byfield,

Stacey,

Bailey

2024

Experimental Physiology

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Cognitive decline and spinal pain (back pain [BP] and neck pain [NP]) represent a major public health challenge, yet the potential relationship between them remains elusive. A retrospective analysis of the Longitudinal Study of Ageing Danish Twins was performed to determine any potential relationships between BP/NP and cognitive function adjusting for age, sex, educational and socioeconomic status. A total of 4731 adults (2788 females/1943 males) aged 78 ± 6 (SD) years were included in the analysis. We observed a 1‐month prevalence of 25% with BP, 21% with NP and 11% for combined BP/NP. While there were no differences in cognition scores for males and females reporting combined BP/NP, compared to those without combined BP/NP (34.38 points [95% confidence interval (CI) = 31.88, 36.88] vs. 35.72 points [95% CI = 35.19, 36.26]; P = 0.180; and 35.72 points [95% CI = 35.19, 36.26] vs. 35.85 points [95% CI = 35.39, 36.31]; P = 0.327; for male and females, respectively), an adjusted analysis revealed that males with combined BP/NP presented with lower cognitive scores compared to males without combined BP/NP (81.26 points [95% CI = 73.80, 88.72] vs. 79.48 points [95% CI = 70.31, 88.66]; P = 0.043). The findings of this hypothesis‐generating study may highlight a potential sex‐specific association between spinal pain and later‐life neurodegeneration.

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“…Low back pain (LBP) is the leading cause of disability globally with more than 600 million people worldwide experiencing it. 17 Among people with LBP, the majority has nonspecific LBP (NSLBP), meaning that a specific pathoanatomical cause for the pain cannot be detected. 31 For people with NSLBP, a large array of health interventions are available and are tested in randomized controlled trials (RCTs).…”

Section: Introductionmentioning

confidence: 99%

Clinical improvements due to specific effects and placebo effects in conservative interventions and changes observed with no treatment in randomized controlled trials of patients with chronic nonspecific low back pain: a systematic review and meta-analysis

Pedersen,

Strijkers,

Gerger

et al. 2024

Pain

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Little is known about the contribution of placebo effects and changes observed with no treatment in interventions for nonspecific low back pain (NSLBP). This systematic review assessed the proportions of the overall treatment effect that may be attributable to specific treatment effects, placebo effects, and changes observed with no treatment in randomized controlled trials (RCTs) in patients with NSLBP. Trials published before 2019 were identified from a published systematic review, and the search was updated in MEDLINE, Embase, and Cochrane Central for trials published between January 2019 and March 2023. Three-arm RCTs comparing the effects of experimental interventions vs placebo control vs no intervention reporting pain intensity, physical function, and/or health-related quality of life (HRQoL) were included. Sixteen RCTs with 1436 adults with chronic NSLBP testing conservative and mainly passive interventions were included. For pain intensity (16 studies), 33%, 18%, and 49% of the overall short-term treatment effect was attributable to specific treatment effects, placebo effects, and changes observed with no treatment, respectively. For physical function (11 studies) and HRQoL (6 studies), these proportions were 34%, 13%, and 53%, and 11%, 41%, and 48%, respectively. These results show that approximately half of the overall treatment effect of conservative and mainly passive interventions for patients with chronic NSLBP is attributable to changes observed with no treatment, rather than specific or placebo effects of treatments. However, the certainty of evidence was very low to low, suggesting that the true effects might be markedly different from the effect sizes underlying these estimates.

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Global, Regional, and National Burden of Low Back Pain, 1990–2020, Its Attributable Risk Factors, And Projections to 2050: A Systematic Analysis of the Global Burden of Disease Study 2021

Cited by 51 publications

References 11 publications

Spinal Pain, Chronic Health Conditions and Health Behaviors: Data from the 2016–2018 National Health Interview Survey

Spinal Pain, Chronic Health Conditions and Health Behaviors: Data from the 2016–2018 National Health Interview Survey

Cognition is selectively impaired in males with spinal pain: A retrospective analysis of data from the Longitudinal Study of Ageing Danish Twins

Clinical improvements due to specific effects and placebo effects in conservative interventions and changes observed with no treatment in randomized controlled trials of patients with chronic nonspecific low back pain: a systematic review and meta-analysis

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