Global proteomic profiling reveals altered proteomic signature in schizophrenia serum

Levin, Yishai; Wang, L; Schwarz, Emanuel; Koethe, Dagmar; Leweke, F. Markus; Bahn, Sabine

doi:10.1038/mp.2009.54

Cited by 108 publications

(86 citation statements)

References 164 publications

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“…Given the reported pool of findings it seems unlikely that a difference in any single molecule would be enough to assign a given animal model to a distinct psychiatric disorder. This is in line with biomarker findings which have focussed on altered patterns rather than changes of single proteins 200 . For example it has been shown that a combination of 51 serum biomarkers can be used in humans to help with the diagnosis of schizophrenia 201 .…”

Section: Discussionsupporting

confidence: 71%

Estudos traducionais de neuropsiquiatria e esquizofrenia: modelos animais genéticos e de neurodesenvolvimento

Gottschalk

Sarnyai

Guest

et al. 2012

Arch. Clin. Psychiatry (São Paulo)

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Psychiatric symptoms are subjective by nature and tend to overlap between different disorders. The modelling of a neuropsychiatric disorder therefore faces challenges because of missing knowledge of the fundamental pathophysiology and a lack of accurate diagnostics. Animal models are used to test hypotheses of aetiology and to represent the human condition as close as possible to increase our understanding of the disease and to evaluate new targets for drug discovery. In this review, genetic and neurodevelopmental animal models of schizophrenia are discussed with respect to behavioural and neurophysiological findings and their association with the clinical condition. Only specific animal models of schizophrenia may ultimately lead to novel diagnostic approaches and drug discovery. We argue that molecular biomarkers are important to improve animal to human translation since behavioural readouts lack the necessary specificity and reliability to assess human psychiatric symptoms.Gottschalk MG, et al. / Rev Psiq Clín. 2013;40(1):41-50 Keywords: Translational research, neuropsychiatry, genetic, neurodevelopment, animal model, schizophrenia. ResumoSintomas psiquiátricos são subjetivos por natureza e tendem a se sobrepor entre diferentes desordens. Sendo assim, a criação de modelos de uma desordem neuropsiquiátrica encontra desafios pela falta de conhecimento dos fundamentos da fisiopatologia e diagnósticos precisos. Modelos animais são usados para testar hipóteses de etiologia e para representar a condição humana tão próximo quanto possível para aumentar nosso entendimento da doença e avaliar novos alvos para a descoberta de drogas. Nesta revisão, modelos animais genéticos e de neurodesenvolvimento de esquizofrenia são discutidos com respeito a achados comportamentais e neurofisiológicos e sua associação com a condição clínica. Somente modelos animais específicos de esquizofrenia podem, em último caso, levar a novas abordagens diagnósticas e descoberta de drogas. Argumentamos que biomarcadores moleculares são importantes para aumentar a tradução de animais a humanos, já que faltam a especificidade e a fidelidade necessárias às leituras comportamentais para avaliar sintomas psiquiátricos humanos.Gottschalk MG, et al. / Rev Psiq Clín. 2013;40(1):41-50

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Section: Discussionsupporting

confidence: 71%

Estudos traducionais de neuropsiquiatria e esquizofrenia: modelos animais genéticos e de neurodesenvolvimento

Gottschalk

Sarnyai

Guest

et al. 2012

Arch. Clin. Psychiatry (São Paulo)

View full text Add to dashboard Cite

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“…But each also remains curiously under-represented in mainstream GxE research today. This is despite evidence to suggest they may serve a functional purpose as biomarkers of environmentally-induced pathogenesis, susceptibility, illness progression and treatment outcome [146][147][148][149][150][151][152] . Despite these documented examples, each discipline also faces thematic questions about how to achieve methodological best practice, given their various respective constraints 147,153,154 .…”

Section: Resultsmentioning

confidence: 94%

Old Obstacles on New Horizons: The Challenge of Implementing Gene X Environment Discoveries in Schizophrenia Research

Iyegbe

Modinos

Sanchez³

2012

Public Health - Methodology, Environmental and Systems Issues

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“…Ten proteins were found differentially expressed in a set of 55 samples from first-onset drug-naive SCZ patients in comparison to 33 controls 19 . These proteins were adapted into a DiscoveryMAP multiplex immunoassay platform (Myriad Genetics) leading to a blood test capable of distinguishing drug-naïve SCZ patients from controls.…”

Section: Serum and Skin Fibroblastsmentioning

confidence: 99%

Análise proteômica da esquizofrenia

Oliveira

Martins-de-Souza²

2012

Arch. Clin. Psychiatry (São Paulo)

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Valuable knowledge about schizophrenia has been recently generated for deciphering its pathobiology and revealing biomarkers. However, efforts are still needed, especially if we take in account that this debilitating mental disorder affects approximately 30 million people worldwide. Considering that schizophrenia is a result of a complex interaction among environmental factors altered gene function and systematic differential protein expression, proteomics is likely to be a suitable tool for studying this disorder. Here we synthetize the main findings by proteomic studies and further directions to be taken in order to better comprehend the biochemistry of schizophrenia as well as reveal biomarkers. In addition, we summarize proteomic methodologies used in such studies.Oliveira BM, Martins-de-Souza D / Rev Psiq Clín. 2013;40(1):16-9 Keywords: Proteomics, schizophrenia, mass spectrometry, energy metabolism, oligodendrocytes. ResumoValioso conhecimento a respeito de esquizofrenia tem sido gerado recentemente para decifrar sua patobiologia e revelar biomarcadores. Entretanto, esforços ainda são necessários, especialmente se levarmos em conta que essa debilitante desordem mental afeta aproximadamente 30 milhões de pessoas ao redor do mundo. Considerando que esquizofrenia é resultado de uma complexa interação entre fatores ambientais, função genética alterada e expressão proteica diferencial sistemática, a proteômica é provavelmente uma ferramenta adequada ao estudo dessa desordem. Aqui sintetizamos os principais achados em estudos proteômicos e posteriores direções a serem tomadas de forma a melhor compreender a bioquímica da esquizofrenia, bem como revelar biomarcadores.Oliveira BM, Martins-de-Souza D / Rev Psiq Clín. 2013;40(1):16-9 Palavras-chave: Proteômica, esquizofrenia, espectrometria de massas, metabolismo de energia, oligodendrócitos.

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Global proteomic profiling reveals altered proteomic signature in schizophrenia serum

Cited by 108 publications

References 164 publications

Estudos traducionais de neuropsiquiatria e esquizofrenia: modelos animais genéticos e de neurodesenvolvimento

Estudos traducionais de neuropsiquiatria e esquizofrenia: modelos animais genéticos e de neurodesenvolvimento

Old Obstacles on New Horizons: The Challenge of Implementing Gene X Environment Discoveries in Schizophrenia Research

Análise proteômica da esquizofrenia

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