Global profiling of the crotonylome in Small Cell Lung Cancer

Guo, Zongpei; Gu, Meng; Huang, Jiaqiang; Zhou, Pingkun; Ma, Teng

doi:10.1101/2020.06.29.175877

Cited by 3 publications

(1 citation statement)

References 18 publications

(16 reference statements)

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“…When comparing small cell lung tissues with paired normal lung tissues from different patients, several tumor metastasis and tumor microenvironment regulators, such as caveolin-1, platelets, endothelial cell adhesion molecule 1, and stathmin 1 (STMN1), are modified by Kcr, underlying the broad spectrum of functions of Kcr-modified proteins in small cell lung cancer (SCLC). Additionally, the authors showed that crotonyl-CoA transferases, including KAT2A, KAT8, and p300, exhibit relatively higher expressions in SCLC, while only p300 had a positive overall survival in the Kaplan–Meier survival analysis [ 161 ]. Additionally, it is well known that M2-polarized tumor-associated macrophages are responsible for cancer progression and metastasis and promote the migration and invasion of lung cancer cells, resulting in decreased overall survival in tumor-bearing mice [ 162 ].…”

Section: Roles Of Novel Acylations In Tumor Metastasesmentioning

confidence: 99%

A glimpse into novel acylations and their emerging role in regulating cancer metastasis

Shi,

Cui,

Qin

et al. 2024

Cell. Mol. Life Sci.

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Metastatic cancer is a major cause of cancer-related mortality; however, the complex regulation process remains to be further elucidated. A large amount of preliminary investigations focus on the role of epigenetic mechanisms in cancer metastasis. Notably, the posttranslational modifications were found to be critically involved in malignancy, thus attracting considerable attention. Beyond acetylation, novel forms of acylation have been recently identified following advances in mass spectrometry, proteomics technologies, and bioinformatics, such as propionylation, butyrylation, malonylation, succinylation, crotonylation, 2-hydroxyisobutyrylation, lactylation, among others. These novel acylations play pivotal roles in regulating different aspects of energy mechanism and mediating signal transduction by covalently modifying histone or nonhistone proteins. Furthermore, these acylations and their modifying enzymes show promise regarding the diagnosis and treatment of tumors, especially tumor metastasis. Here, we comprehensively review the identification and characterization of 11 novel acylations, and the corresponding modifying enzymes, highlighting their significance for tumor metastasis. We also focus on their potential application as clinical therapeutic targets and diagnostic predictors, discussing the current obstacles and future research prospects.

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Section: Roles Of Novel Acylations In Tumor Metastasesmentioning

confidence: 99%

A glimpse into novel acylations and their emerging role in regulating cancer metastasis

Shi,

Cui,

Qin

et al. 2024

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

show abstract

Protein crotonylation: Basic research and clinical diseases

Li,

Lin,

et al. 2024

Biochemistry and Biophysics Reports

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Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification

et al. 2022

J Exp Clin Cancer Res

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Metabolites are intermediate products of cellular metabolism catalysed by various enzymes. Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal metabolite accumulation. These metabolites mainly generate energy or serve as signal transduction mediators via noncovalent interactions. After the development of highly sensitive mass spectrometry technology, various metabolites were shown to covalently modify proteins via forms of lysine acylation, including lysine acetylation, crotonylation, lactylation, succinylation, propionylation, butyrylation, malonylation, glutarylation, 2-hydroxyisobutyrylation and β-hydroxybutyrylation. These modifications can regulate gene expression and intracellular signalling pathways, highlighting the extensive roles of metabolites. Lysine acetylation is not discussed in detail in this review since it has been broadly investigated. We focus on the nine aforementioned novel lysine acylations beyond acetylation, which can be classified into two categories: histone acylations and nonhistone acylations. We summarize the characteristics and common functions of these acylation types and, most importantly, provide a glimpse into their fine-tuned control of tumorigenesis and potential value in tumour diagnosis, monitoring and therapy.

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Global profiling of the crotonylome in Small Cell Lung Cancer

Cited by 3 publications

References 18 publications

A glimpse into novel acylations and their emerging role in regulating cancer metastasis

A glimpse into novel acylations and their emerging role in regulating cancer metastasis

Protein crotonylation: Basic research and clinical diseases

Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification

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