Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis

Hooi, James K.Y.; Lai, Wan Ying; Ng, Wee Khoon; Suen, Michael; Underwood, Fox E.; Tanyingoh, Divine; Malfertheiner, Peter; Graham, David Y.; Wong, Vincent Wai‐Sun; Wu, Justin C.Y.; Chan, Francis K.L.; Sung, Joseph J.Y.; Kaplan, Gilaad G.; Ng, Siew C.

doi:10.1053/j.gastro.2017.04.022

Cited by 2,171 publications

(1,877 citation statements)

References 29 publications

(22 reference statements)

Supporting

Mentioning

1,702

Contrasting

Unclassified

Order By: Relevance

“…Helicobacter pylori infection and gastric cancer are endemic to Japan and China, as well as Korea 1, 13. Japan has shown a decrease in H. pylori prevalence, similar to Korea.…”

Section: Discussionmentioning

confidence: 99%

“…Helicobacter pylori ( H. pylori ) has infected more than half of the world's population1 and is an important cause of gastric cancer, mucosal‐associated lymphoid tissue lymphoma, and peptic ulcer disease 2. Chronic infection with H. pylori is strongly associated with gastric cancer3 the highest incidence of which is observed in Korea, Mongolia, Japan, and China 4.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016

et al. 2018

View full text Add to dashboard Cite

BackgroundThe Korean College of Helicobacter and Upper Gastrointestinal Research has studied Helicobacter pylori (H. pylori) prevalence since 1998 and found a dynamic change in its prevalence in Korea. The aim of this study was to determine the recent H. pylori prevalence rate and compare it with that of previous studies according to socioeconomic variables.MethodsWe planned to enroll 4920 asymptomatic Korean adults from 21 centers according to the population distribution of seven geographic areas (Seoul, Gyeonggi, Gangwon, Chungcheong, Kyungsang, Cholla, and Jeju). We centrally collected serum and tested H. pylori serum IgG using a chemiluminescent enzyme immunoassay.ResultsWe analyzed 4917 samples (4917/4920 = 99.9%) from January 2015 to December 2016. After excluding equivocal serologic results, the H. pylori seropositivity rate was 51.0% (2414/4734). We verified a decrease in H. pylori seroprevalence compared with previous studies performed in 1998, 2005, and 2011 (P < .0001). The H. pylori seroprevalence rate differed by area: Cholla (59.5%), Chungcheong (59.2%), Kyungsang (55.1%), Jeju (54.4%), Gangwon (49.1%), Seoul (47.4%), and Gyeonggi (44.6%). The rate was higher in those older than 40 years (38.1% in those aged 30‐39 years and 57.7% in those aged 40‐49 years) and was lower in city residents than in noncity residents at all ages.Conclusions Helicobacter pylori seroprevalence in Korea is decreasing and may vary according to population characteristics. This trend should be considered to inform H. pylori‐related policies.

show abstract

“…Helicobacter pylori infection and gastric cancer are endemic to Japan and China, as well as Korea 1, 13. Japan has shown a decrease in H. pylori prevalence, similar to Korea.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016

et al. 2018

View full text Add to dashboard Cite

show abstract

“…There are great differences in prevalence patterns of H. pylori infection worldwide which depend on the level of urbanization, hygiene, sanitation, access to clean water and other socioeconomic factors (2)(3)(4). Bacterial virulence factors are affecting the final outcome of the diseases and currently, finding those factors are the main question mark for gastroenterologists and microbiologists (5).…”

Section: Current Dilemma: Viewpointsmentioning

confidence: 99%

A report on Allelic Variation in Helicobacter pylori dupA: A viewpoint

Fatahi

Abadi

2017

Res Mol Med (RMM)

View full text Add to dashboard Cite

Helicobacter pylori (H. pylori) is the pivotal cause of chronic gastritis, peptic ulcer diseases (PUD) and gastric cancer. Morphologically, the bacterium is spiral, Gram-negative and microaerophilic which survives lifespan in the human stomach in case of weak antibiotic therapy. There is a major difference in the pattern of global prevalence of H. pylori infection based on different levels of urbanization, hygiene, sanitation, access to clean water and other socioeconomic factors. To date, many studies have attempted to find significant associations between specific gastroduodenal diseases and dupA-positive strains, but no conclusive conclusion has been declared. The main reason for these inconsistent findings is the various methodologies applied in experiments which in turn have resulted in inaccurate observation. Our analysis showed that the existence of various alleles located in the dupA cluster would be a novel explanation for different associations found between this bacterial gene and diseases. In detailed experiments examining our proposed alleles using a large number of patients can be useful to disclose a significant clinical association between H. pylori dupA-positive strains and duodenal ulcer.

show abstract

“…Helicobacter pylori (H. pylori) infection is the most diffused chronic bacterial infection worldwide, after dental caries. H. pylori is a gram-negative, micro-aerophilic and acidophilic bacterium present in the stomachs of approximately half the world's population [31,32]. It is the only microorganism capable of living in the hostile gastric environment of man for the entire host's life [3,32] and causes acute and chronic gastritis that greatly increases the risk of peptic ulcers and gastric cancer [3,32,33].…”

Section: Introductionmentioning

confidence: 99%

“…H. pylori is a gram-negative, micro-aerophilic and acidophilic bacterium present in the stomachs of approximately half the world's population [31,32]. It is the only microorganism capable of living in the hostile gastric environment of man for the entire host's life [3,32] and causes acute and chronic gastritis that greatly increases the risk of peptic ulcers and gastric cancer [3,32,33]. The cellular and humoral immune response to the infection stimulates the secretion of chemokines, thus contributing to enhance the systemic inflammatory status [34,35].…”

Section: Introductionmentioning

confidence: 99%

Is Sudden Sensori-neural Hearing Loss an Additional Extra Digestive Disease Associated with HP Infection?

Ponzetto¹,

Cavallo²,

Alushi³

et al. 2017

J Clin Gastroenterol Hepatol

View full text Add to dashboard Cite

Background: Sudden Sensori-neural Hearing Loss (SSHL) is an abrupt failure of the cochlear function of unknown etiology. Possible causes include chronic infections leading to increased systemic levels of cytokines, which could damage the cochlear pumps H + , K + -and Na + , K + -ATPases. Helicobacter pylori infection stimulates systemic cytokine production. Proton pumps in cochlea and stomach are almost identical.

show abstract

Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis

Cited by 2,171 publications

References 29 publications

Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016

Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016

A report on Allelic Variation in Helicobacter pylori dupA: A viewpoint

Is Sudden Sensori-neural Hearing Loss an Additional Extra Digestive Disease Associated with HP Infection?

Contact Info

Product

Resources

About