Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis

Eusebi, Leonardo Henry; Ratnakumaran, Raguprakash; Yuan, Yuhong; Solaymani‐Dodaran, Masoud; Bazzoli, Franco; Ford, Alexander C

doi:10.1136/gutjnl-2016-313589

Cited by 454 publications

(432 citation statements)

References 122 publications

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“…Additionally, the face‐to‐face interviews allowed the enrollment of poorly educated participants, who are usually ignored in mail‐ and internet‐based studies. A recent meta‐analysis of the global prevalence of GER symptoms has shown that the pooled prevalence of GER identified using face‐to‐face interviews was 14.1%, which falls between that obtained using postal questionnaires and telephone interviews (19.0% and 10.4%, respectively) …”

Section: Discussionmentioning

confidence: 79%

“…GER was defined as heartburn and/or acid reflux and/or regurgitation of food at least once a week, and monthly reflux was defined as at least one of the abovementioned symptoms occurring at least 1‐3 days per month . If the participants had either no episodes or episodes on <1 day per month, they were considered reflux‐free.…”

Section: Participants and Methodsmentioning

confidence: 99%

“…Symptomatic gastroesophageal reflux (GER) is common in the general population worldwide . Over the past two decades, the prevalence of GER in the general population, the number of patients who visit primary‐care doctors and gastroenterologists for gastroesophageal reflux disease (GERD)‐related problems, the detection rate of reflux esophagitis by endoscopy, and the use of proton pump inhibitors (PPIs) for GERD have all been increasing.…”

Section: Introductionmentioning

confidence: 99%

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Natural history of gastroesophageal reflux: A prospective cohort study in a stratified, randomized population in Beijing

Fang

Zhu

et al. 2019

J of Digest Diseases

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Objective To explore the natural history of and risk factors for gastroesophageal reflux (GER) in a prospective cohort in Beijing, China. Methods We selected adult participants using a stratified randomized method and performed initial surveys in 1996 and the current survey in 2008. Well‐trained investigators administered the survey questionnaire using face‐to‐face interviews. Reflux symptoms were evaluated by their intensity and frequency. GER was defined as heartburn, acid reflux, and food regurgitation at least once a week, and monthly reflux was defined as at least one of the above symptoms occurring 1‐3 days per month. Results The resurvey response rate was 47.8% (1189/2486). Over 12 years, 66.9% of the respondents remained unchanged, and one‐third changed, with a GER new onset rate of 7.0 per 1000 person‐years and a GER disappearance rate of 64.6 per 1000 person‐years. This kept the GER prevalence stable at 8.2% to 9.5% (P = 0.28). GER and monthly reflux exhibited significant differences in their tendency to persist or become aggravated to GER (22.4% vs 11.9%, P = 0.02). Participants who initially had single, mild to moderate, daily GER were more likely to recover from reflux over time. Participants with persistent and aggravated GER had more severe heartburn and acid reflux than those with new‐onset GER in the current survey. Multiple logistic regression analysis showed that emotional depression is a risk factor for GER aggravation (odds ratio 3.52, 95% confidence interval 1.43‐8.67, P = 0.006). Conclusion The initial symptom profile of reflux determines the outcome of GER over time.

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Section: Discussionmentioning

confidence: 79%

Section: Participants and Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Natural history of gastroesophageal reflux: A prospective cohort study in a stratified, randomized population in Beijing

Fang

Zhu

et al. 2019

J of Digest Diseases

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“…In that study, the association between GERD and malignancy of the larynx was greater than any other subsite of the upper aerodigestive tract. This has clinical importance as GERD affects up to 30% of the elderly population and is more commonly encountered in elderly or obese patients …”

Section: Discussionmentioning

confidence: 99%

Detection of laryngeal carcinoma in the U.S. elderly population with gastroesophageal reflux disease

Riley¹,

Marino

Hsieh

et al. 2019

Head & Neck

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Background An association is suggested between gastroesophageal reflux disease (GERD) or laryngopharyngeal reflux (LPR) and malignancy of the larynx in elderly patients in the United States. Early detection with flexible fiberoptic laryngoscopy (FFL) or CT remains poorly defined. Methods The Surveillance, Epidemiology, and End Results (SEER)‐Medicare linked database was queried from 2003 to 2011.A case‐cohort design evaluated patients aged 66 and older with a diagnosis of GERD and/or LPR for the occurrence of FFL or CT within 6 months of the exposure diagnosis. Results Of a total 156 426 Medicare beneficiaries, the relative risk of early cancer diagnosis with FFL was 14.61(95% confidence interval [CI], 13.59‐15.70), corresponding to a number needed to detect (NND) a case of cancer of 13(95% CI, 13‐14). The relative risk of an early cancer diagnosis with CT was 31.83 (95% CI, 29.57‐34.26), with a NND of 5 (95% CI, 5‐5). Conclusions Early FFL and CT are associated with a higher likelihood of laryngeal cancer diagnosis in elderly individuals with a diagnosis of reflux. Screening trials are necessary to establish this relationship.

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“…The prevalence is modestly considered as 10% in adults, since the existing evidence has a broad range between 2.5% and 50% worldwide 22 and between 10% and 20% in the Western world. The prevalence is modestly considered as 10% in adults, since the existing evidence has a broad range between 2.5% and 50% worldwide 22 and between 10% and 20% in the Western world.…”

Section: Tooth Wear Parametersmentioning

confidence: 99%

A methodology for evaluating tooth wear monitoring using timed automata modelling

Wetselaar

Lobbezoo

Jong

et al. 2019

J of Oral Rehabilitation

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Objectives Tooth wear is a multifactorial condition leading to the loss of dental hard tissues. A counselling/monitoring protocol is of importance in order to keep that loss as limited as possible. Since many factors are involved and a time span of decades is included, research to disentangle all these processes in patients is difficult. Instead, a modelling technique was used that is able to deal with time, costs and probabilistic and stochastic information. The aim was to shed light on the question: does a yearly or a once‐in‐five‐years counselling/monitoring protocol yield better outcome measures? Methods A so‐called timed automata model was adopted, analysed with the tool UPPAAL. To our knowledge, this is the first time that formal modelling is applied in dentistry. In this article, a UPPAAL model for the evaluation of tooth wear is described. Results Using the UPPAAL model, it was calculated that with a yearly counselling/monitoring protocol the severity of tooth wear at age 74, the total costs per person and the number of restorative treatments were less, and the number of so‐called “good years” was higher. Conclusions With the use of the UPPAAL model, it may be concluded that a yearly counselling/monitoring protocol can yield better outcome measures. Clinical Significance Regarding dentistry in general and tooth wear in particular, with the use of a timed automata model in UPPAAL, actual research questions can be answered, factors of influence in a multifactorial condition like tooth wear can be clarified, and future research topics can be determined.

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Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis

Cited by 454 publications

References 122 publications

Natural history of gastroesophageal reflux: A prospective cohort study in a stratified, randomized population in Beijing

Natural history of gastroesophageal reflux: A prospective cohort study in a stratified, randomized population in Beijing

Detection of laryngeal carcinoma in the U.S. elderly population with gastroesophageal reflux disease

A methodology for evaluating tooth wear monitoring using timed automata modelling

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