Global Prevalence and Severity of Retinopathy of Prematurity over the Last Four Decades (1985–2021): A Systematic Review and Meta-Analysis

García, Heladia; Villasis-Keever, Miguel Angel; Zavala-Vargas, Georgina; Bravo-Ortiz, Juan Carlos; Pérez-Méndez, Ayari; Escamilla-Núñez, Alberto

doi:10.1016/j.arcmed.2024.102967

Cited by 5 publications

(2 citation statements)

References 131 publications

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“…With increasing neonatal care and the living rate of premature infants, ROP is a worldwide problem. Previous studies have reported a 33-73% incidence of ROP (at any stage) in preterm infants less than 27-28 weeks and severe ROP in 16-35% [9][10][11][12][13]. Awareness and knowledge of ROP may be given to all healthcare providers, including nurses [14,15].…”

Section: Discussionmentioning

confidence: 99%

The Awareness and Knowledge of Retinopathy of Prematurity Among Pediatricians in Saudi Arabia

Abdelhalim,

Alotaibi,

Alruwais

et al. 2024

Cureus

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Background: Retinopathy of prematurity (ROP) affects premature low birth-weight infants with potentially blinding complications. Early diagnosis and treatment for indicated cases are essential to prevent unfavorable effects of the disease. Objectives: To determine the awareness and the level of knowledge of ROP among pediatricians in all regions of Saudi Arabia who worked at neonatal intensive care units. Design and setting: This was a cross-sectional study. This study was undertaken in the Kingdom of Saudi Arabia. Materials and methods: A semi-self-structured online questionnaire was designed to study the awareness and knowledge of ROP. The questionnaire contained items related to demographic data, participants’ level of understanding and knowledge of ROP, and items related to hospital facilities, the availability of a trained ophthalmologist, and the source of knowledge. Main outcome measures: The awareness and knowledge of ROP among pediatricians of the Kingdom of Saudi Arabia. Sample size: The study included 145 pediatricians. Results: Awareness of ROP was found in 138 participants (95.2%). Seven participants (4.8%) were not aware of ROP and were excluded from further analysis. Of the participants, 116 (84.0%), 127 (92.0%), and 130 (94.3%) had knowledge about the stages, treatment, and precautions of treatment of ROP, respectively. Of the participants, 77 (55.8%), 63 (45.7%), 113 (81.9%), and 56 (40.6%) gave the correct answer about the indications of fundus examination, exact time of the first fundus examination, place of fundus examination, and minimum number of screening fundus examination for ROP, respectively. Conclusions: The awareness and knowledge of ROP among pediatricians of Saudi Arabia is good, but knowledge about the indications and proper time of first referral to an ophthalmologist should be improved.

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Section: Discussionmentioning

confidence: 99%

The Awareness and Knowledge of Retinopathy of Prematurity Among Pediatricians in Saudi Arabia

Abdelhalim,

Alotaibi,

Alruwais

et al. 2024

Cureus

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“…RNV is a common ocular condition that threatens human vision and is a component of many diseases including ROP, AMD, and DR. 41 Among these, ROP is one of the leading causes of childhood blindness worldwide. 42 , 43 Currently, methods to treat ROP produce only modest benefits; anti‐VEGFA and laser ablation therapy can temporarily control neovascularization, but the long‐term efficacy is limited, and repeated anti‐VEGF injection may cause VEGFA resistance and other side effects in children. 44 , 45 Therefore, more efficient and safer therapeutic strategies are urgently needed.…”

Section: Discussionmentioning

confidence: 99%

Autophagy‐mediated activation of the AIM2 inflammasome enhances M1 polarization of microglia and exacerbates retinal neovascularization

Liu,

Zhou,

Meng

et al. 2024

MedComm

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Retinopathy of prematurity (ROP) is a retinal neovascularization (RNV) disease that is characterized by abnormal blood vessel development in the retina. Importantly, the etiology of ROP remains understudied. We re‐analyzed previously published single‐cell data and discovered a strong correlation between microglia and RNV diseases, particularly ROP. Subsequently, we found that reactive oxygen species reduced autophagy‐dependent protein degradation of absent in melanoma 2 (AIM2) in hypoxic BV2 cells, leading to increased AIM2 protein accumulation. Furthermore, we engineered AIM2 knockout mice and observed that the RNV was significantly reduced compared to wild‐type mice. In vitro vascular function assays also demonstrated diminished angiogenic capabilities following AIM2 knockdown in hypoxic BV2 cells. Mechanistically, AIM2 enhanced the M1‐type polarization of microglia via the ASC/CASP1/IL‐1β pathway, resulting in RNV. Notably, the administration of recombinant protein IL‐1β exacerbated angiogenesis, while its inhibition ameliorated the condition. Taken together, our study provides a novel therapeutic target for ROP and offers insight into the interaction between pyroptosis and autophagy.

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The impact of gut microbiota on morbidities in preterm infants

Lai,

Chang,

Lee

2024

The Kaohsiung J of Med Scie

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The gut microbiota undergoes substantial development from birth, and its development in the initial years of life has a potentially lifelong effect on the health of the individual. However, various factors can disrupt the development of the gut microbiota, leading to a condition known as dysbiosis, particularly in preterm infants. Current studies involving adults have suggested that the gut microbiota not only influences the gut but also has multidimensional effects on remote organs; these pathways are often referred to as the gut–organ axis. Imbalance of the gut microbiota may lead to the development of multiple diseases. Recent studies have revealed that gut dysbiosis in preterm infants may cause several acute morbidities—such as necrotizing enterocolitis, late‐onset sepsis, bronchopulmonary dysplasia, and retinopathy of prematurity—and it may also influence long‐term outcomes including neurodevelopment and somatic growth. This review mainly presents the existing evidence regarding the relationships between the gut microbiota and these morbidities in preterm infants and explores the role of the gut–organ axis in these morbidities. This paper thus offers insights into the future perspectives on microbiota interventions for promoting the health of preterm infants.

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Global Prevalence and Severity of Retinopathy of Prematurity over the Last Four Decades (1985–2021): A Systematic Review and Meta-Analysis

Cited by 5 publications

References 131 publications

The Awareness and Knowledge of Retinopathy of Prematurity Among Pediatricians in Saudi Arabia

The Awareness and Knowledge of Retinopathy of Prematurity Among Pediatricians in Saudi Arabia

Autophagy‐mediated activation of the AIM2 inflammasome enhances M1 polarization of microglia and exacerbates retinal neovascularization

The impact of gut microbiota on morbidities in preterm infants

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