Global posterior prevalence is unique to vertebrates: A dance to the music of time?

Durston, Antony J.

doi:10.1002/dvdy.23852

Cited by 21 publications

(24 citation statements)

References 71 publications

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“…This is an extremely beautiful and important proposition, but it is not supported by our observations (above). (44,48) but also requires a second signal to generate the correct spatial sequence of Hox expression in the axial pattern. We think that this second signal is delivered by interactions between the Hox genes (C) (44).…”

Section: Discussionmentioning

confidence: 99%

Dislocation is a developmental mechanism in Dictyostelium and vertebrates

Durston

2013

Proc. Natl. Acad. Sci. U.S.A.

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The excitable cells of Dictyostelium discoideum show traveling waves of signaling and generate a variety of complex wave forms during their morphogenesis. Important among these wave forms is the 3D spiral or scroll wave, which has been proposed previously to have a twisted variant: the "turbine wave." Herein we argue that a D. discoideum scroll or concentric wave territory containing prespore and prestalk cell types can undergo "dislocation": a wave field that initially controls aggregation of a whole developing population of Dictyostelium cells splits into two. This process leads to discontinuity between two connected domains of wave propagation and to specific phenomena, including high-frequency concentric pacemaker activity by the slime mold's scroll-wave tip. The resulting morphogenetic events reveal a unique mechanism in morphogenesis.T he organism Dictyostelium discoideum has attracted eminent mathematicians, theoretical physicists, and computer scientists to biology. Pioneering observations by John Bonner, Theo Konijn, and their colleagues (1, 2), and by Brian Shaffer (3), respectively, in the 1960s and 1970s demonstrated that chemotaxis to cAMP and cAMP signal relay, respectively, are the key cell properties that mediate aggregation in this organism. These early insights have only recently fully borne fruit. The complex relayed waves of cAMP signaling and chemotaxis generated by these two simple properties mean that a mass of D. discoideum cells behaves as an isotropic excitable medium (4) and generates a range of complex and beautiful behaviors and structures: notably, structures based on scroll waves. It was thought initially that these waves mediated only the first (aggregation) stage of D. discoideum development, but it became evident that they organize morphogenesis of all multicellular stages (5-8). The waveforms are mathematically predictable and the structures they organize presumably are as well (Fig.

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Section: Discussionmentioning

confidence: 99%

Dislocation is a developmental mechanism in Dictyostelium and vertebrates

Durston

2013

Proc. Natl. Acad. Sci. U.S.A.

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“…[6]) Hox interactions: (Refs. [5,6,18,[21][22][23][24][25]). Hox genes show collinearity: congruence of spatial and temporal early expression sequences with genomic sequence in Hox clusters (four clusters in vertebrates, 1 in Drosophila).…”

Section: Box 2: Evidence That Time Space Translation (Tst) Is Mediatementioning

confidence: 99%

“…Collinear interactions between Hox genes and Hox associated Mirs are likely. Posterior prevalence [4,21,22,24,25]; inhibition of the expression or function of more anterior Hox genes by more posterior Hox genes and Mirs (the original collinear property associated with Hox collinearity by Lewis). Posterior induction (induction of expression of more posterior genes by more anterior ones) [5,21,22,25].…”

Section: What Is the Molecular Nature Of The A-p Timer And Of Hox Temmentioning

confidence: 99%

“…There is evidence that this occurs but it is not the whole story for Hox temporal collinearity and timing during gastrulation. This involves synchronisation of the structurally different Hox clusters which must involve trans interactions within cells and intercellular interactions between different cells in the synchronised mesoderm of the gastrula [21,22] (Text Box 4, Fig. S4A).…”

Section: What Is the Molecular Nature Of The A-p Timer And Of Hox Temmentioning

confidence: 99%

“…Two interactions could putatively play a role. Posterior prevalence, where posterior Hox genes inhibit expression and function of more anterior ones [4,[21][22][23][24][25]. Posterior induction, where anterior Hox genes induce expression of more posterior ones.…”

Section: What Is the Molecular Nature Of The A-p Timer And Of Hox Temmentioning

confidence: 99%

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