Global patterns of Middle East respiratory syndrome coronavirus (MERS-CoV) prevalence and seroprevalence in camels: A systematic review and meta-analysis

Islam, Md. Mazharul; Khanom, Hamida; Farag, Elmoubashar; Mim, Zarin Tasnim; Naidoo, Pragalathan; Mkhize-Kwitshana, Zilungile Lynette; Tibbo, Markos; Islam, Ariful; Soares Magalhaes, Ricardo J.; Hassan, Mohammad Mahmudul

doi:10.1016/j.onehlt.2023.100561

Cited by 4 publications

(2 citation statements)

References 54 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These species include Alphacoronavirus HCoV-229E and HCoV-NL63; Betacoronavirus HCoV-OC43 and HCoV-HKU1; Middle East Respiratory Syndrome Coronavirus (MERS-CoV); Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV); and SARS-CoV-2 [3]. Out of these seven pathogenic coronaviruses (CoVs), three have caused outbreaks in human populations: SARS-CoV, which accounted for 774 deaths worldwide during 2002-2004 [4]; MERS-CoV, emerging in 2012 and leading to 935 deaths to date [5]; and SARS-CoV-2, which emerged at the end of 2019 and was declared a pandemic by the World Health Organization (WHO) from its outbreak until May 2023 [1]. While the four human-infecting CoVs (HCoV-229E, HCoV-HKU1, HCoV-NL63, and HCoV-OC43) typically result in mild symptoms, SARS-CoV, MERS-CoV, and SARS-CoV-2 exhibit a spectrum of clinical manifestations that range from mild to severe, including fatal outcomes.…”

Section: Introductionmentioning

confidence: 99%

From Detection to Protection: Antibodies and Their Crucial Role in Diagnosing and Combatting SARS-CoV-2

Kumar,

Tripathi,

Kumar

et al. 2024

Vaccines

View full text Add to dashboard Cite

Understanding the antibody response to SARS-CoV-2, the virus responsible for COVID-19, is crucial to comprehending disease progression and the significance of vaccine and therapeutic development. The emergence of highly contagious variants poses a significant challenge to humoral immunity, underscoring the necessity of grasping the intricacies of specific antibodies. This review emphasizes the pivotal role of antibodies in shaping immune responses and their implications for diagnosing, preventing, and treating SARS-CoV-2 infection. It delves into the kinetics and characteristics of the antibody response to SARS-CoV-2 and explores current antibody-based diagnostics, discussing their strengths, clinical utility, and limitations. Furthermore, we underscore the therapeutic potential of SARS-CoV-2-specific antibodies, discussing various antibody-based therapies such as monoclonal antibodies, polyclonal antibodies, anti-cytokines, convalescent plasma, and hyperimmunoglobulin-based therapies. Moreover, we offer insights into antibody responses to SARS-CoV-2 vaccines, emphasizing the significance of neutralizing antibodies in order to confer immunity to SARS-CoV-2, along with emerging variants of concern (VOCs) and circulating Omicron subvariants. We also highlight challenges in the field, such as the risks of antibody-dependent enhancement (ADE) for SARS-CoV-2 antibodies, and shed light on the challenges associated with the original antigenic sin (OAS) effect and long COVID. Overall, this review intends to provide valuable insights, which are crucial to advancing sensitive diagnostic tools, identifying efficient antibody-based therapeutics, and developing effective vaccines to combat the evolving threat of SARS-CoV-2 variants on a global scale.

show abstract

Section: Introductionmentioning

confidence: 99%

From Detection to Protection: Antibodies and Their Crucial Role in Diagnosing and Combatting SARS-CoV-2

Kumar,

Tripathi,

Kumar

et al. 2024

Vaccines

View full text Add to dashboard Cite

show abstract

“…The Middle East Respiratory Syndrome Coronavirus, known scientifically as MERS-CoV and classified under the Coronaviridae lineage, initially made its presence felt in Saudi Arabia in 2012 [1]. Its rapid dissemination across national boundaries evoked heightened global alarm, especially given its pronounced morbidity and mortality rates.…”

Section: Introductionmentioning

confidence: 99%

A Multifaceted Computational Approach to Understanding the MERS-CoV Main Protease and Brown Algae Compounds’ Interaction

Gattan,

Mahmoud Alawi,

Bajrai

et al. 2023

Marine Drugs

View full text Add to dashboard Cite

Middle East Respiratory Syndrome (MERS) is a viral respiratory disease caused b a special type of coronavirus called MERS-CoV. In the search for effective substances against the MERS-CoV main protease, we looked into compounds from brown algae, known for their medicinal benefits. From a set of 1212 such compounds, our computer-based screening highlighted four—CMNPD27819, CMNPD1843, CMNPD4184, and CMNPD3156. These showed good potential in how they might attach to the MERS-CoV protease, comparable to a known inhibitor. We confirmed these results with multiple computer tests. Studies on the dynamics and steadiness of these compounds with the MERS-CoV protease were performed using molecular dynamics (MD) simulations. Metrics like RMSD and RMSF showed their stability. We also studied how these compounds and the protease interact in detail. An analysis technique, PCA, showed changes in atomic positions over time. Overall, our computer studies suggest brown algae compounds could be valuable in fighting MERS. However, experimental validation is needed to prove their real-world effectiveness.

show abstract

The Safety, Immunogenicity, and Optimal Dosing of an MVA-Based Vaccine Against MERS Coronavirus in Healthy Adults: A Phase 1b, Randomised, Placebo-Controlled, Double-Blind Clinical Trial

Raadsen,

Dahlke,

Fathi

et al. 2024

Preprint

View full text Add to dashboard Cite

Global patterns of Middle East respiratory syndrome coronavirus (MERS-CoV) prevalence and seroprevalence in camels: A systematic review and meta-analysis

Cited by 4 publications

References 54 publications

From Detection to Protection: Antibodies and Their Crucial Role in Diagnosing and Combatting SARS-CoV-2

From Detection to Protection: Antibodies and Their Crucial Role in Diagnosing and Combatting SARS-CoV-2

A Multifaceted Computational Approach to Understanding the MERS-CoV Main Protease and Brown Algae Compounds’ Interaction

The Safety, Immunogenicity, and Optimal Dosing of an MVA-Based Vaccine Against MERS Coronavirus in Healthy Adults: A Phase 1b, Randomised, Placebo-Controlled, Double-Blind Clinical Trial

Contact Info

Product

Resources

About