Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium

Quaglino, Pietro; Maule, Milena; Prince, H. Miles; Porcu, Pierluigi; Horwitz, Steven M.; Duvic, Madeleine; Talpur, Rakhshandra; Vermeer, Maarten H.; Bagot, Martine; Guitart, Joan; Papadavid, Evangelia; Sanches, José Antônio; Hodak, Emilia; Sugaya, Makoto; Berti, Emilio; Ortiz‐Romero, Pablo L.; Pimpinelli, Nicola; Servitje, Octavio; Pileri, Alessandro; Zinzani, Pier Luigi; Estrach, Teresa; Knobler, Robert; Stadler, Rudolf; Fierro, Maria Teresa; Violetti, Silvia Alberti; Amitay‐Laish, Iris; Antoniou, Christina; Astrua, Chiara; Chaganti, Sridhar; Child, Fiona; Combalía, Andrea; Fabbro, Stephanie K.; Fava, Paolo; Grandi, Vieri; Jonak, Constanze; Martínez-Escala, Estela; Kheterpal, Meenal; Kim, E. J.; McCormack, Christopher; Miyagaki, Tomomitsu; Miyashiro, Denis; Morris, Stephen; Muniesa, Cristina; Nikolaou, Vasiliki; Ognibene, G.; Onida, Francesco; Osella‐Abate, Simona; Porkert, Stefanie; Postigo‐Llorente, Concepción; Ram‐Wolff, Caroline; Ribero, Simone; Rogers, Kortney; Sanlorenzo, Martina; Stranzenbach, René; Spaccarelli, Natalie; Stevens, Andrea; Zugna, Daniela; Rook, Alain H.; Geskin, Larisa J.; Willemze, Rein; Whittaker, Sean; Hoppe, Richard T.; Scarisbrick, Julia; Kim, Y.

doi:10.1093/annonc/mdx352

Cited by 107 publications

(97 citation statements)

References 29 publications

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“…This shared a similarity with the global patterns of MF put forward by a multicentre retrospective followup study. 1 One study reported that the incidence of CTCL and MF is higher among African American than white individuals in the U.S.A., with earlier onset and more advanced disease, and median age at diagnosis of MF was 47 years, older than in our findings. 2 We also observed from one study that perhaps Asian patients with MF were younger than white, black and mixed-race patients.…”

contrasting

confidence: 68%

Clinical characteristics of primary cutaneous lymphoma: analysis from two centres in China

et al. 2019

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contrasting

confidence: 68%

Clinical characteristics of primary cutaneous lymphoma: analysis from two centres in China

et al. 2019

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“…CTCL is an uncommon but devastating malignancy in advanced stages, with a median survival of <5 years. 29 Geographic clustering has been identified in several regions nationally and internationally, particularly in urban and industrial regions. [10][11][12][13][14] However, the environmental risk factors for CTCL have not been previously evaluated.…”

Section: Discussionmentioning

confidence: 99%

Clustering of cutaneous T‐cell lymphoma is associated with increased levels of the environmental toxins benzene and trichloroethylene in the state of Georgia

Clough

Bayakly

Ward

et al. 2020

Cancer

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Background Cutaneous T‐cell lymphoma (CTCL) is a rare form of non‐Hodgkin lymphoma arising in the skin. Geographic clustering of CTCL has recently been reported, but its association with environmental factors is unknown. Benzene and trichloroethylene (TCE) are environmental toxins with carcinogenic properties. The authors investigated associations between geographic clustering of CTCL incidence in the state of Georgia with benzene and TCE exposure. Methods The statewide county‐level incidence of CTCL within Georgia was obtained from the Georgia Cancer Registry for the years 1999 to 2015. Standardized incidence ratios (SIRs) were calculated by dividing observed cases by expected cases using national incidence rates by age, sex, and race. Clustering of CTCL was analyzed using spatial analyses. County‐level concentrations of benzene and TCE between 1996 and 2014 were collected from the Environmental Protection Agency's National Air Toxics Assessment database. Linear regression analyses on CTCL incidence were performed comparing SIRs with levels of benzene and TCE by county. Results There was significant geographic clustering of CTCL in Georgia, particularly around Atlanta, which was correlated with an increased concentration of benzene and TCE exposure. Among the 4 most populous counties in Georgia, CTCL incidence was between 1.2 and 1.9 times higher than the state average, and benzene and TCE levels were between 2.9 and 8.8 times higher. Conclusions The current results demonstrate nonrandom geographic clustering of CTCL incidence in Georgia. To the authors' knowledge, this is the first analysis to identify a correlation between geographic clustering of CTCL and environmental toxic exposures.

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“…Recently Quaglino et al . published a retrospective analysis of 853 patients with advanced MF/SS from 21 centres . This large, multicentre retrospective study showed a substantial heterogeneity of treatment approaches in advanced MF/SS between U.S. and non‐U.S.…”

Section: Treatment Of Mycosis Fungoides/sézary Syndromementioning

confidence: 99%

British Association of Dermatologists and U.K. Cutaneous Lymphoma Group guidelines for the management of primary cutaneous lymphomas 2018

et al. 2018

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Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium

Cited by 107 publications

References 29 publications

Clinical characteristics of primary cutaneous lymphoma: analysis from two centres in China

Clinical characteristics of primary cutaneous lymphoma: analysis from two centres in China

Clustering of cutaneous T‐cell lymphoma is associated with increased levels of the environmental toxins benzene and trichloroethylene in the state of Georgia

British Association of Dermatologists and U.K. Cutaneous Lymphoma Group guidelines for the management of primary cutaneous lymphomas 2018

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