Global patterns of breast cancer incidence and mortality: A population‐based cancer registry data analysis from 2000 to 2020

Abstract

Background: Breast cancer is the most commonly diagnosed cancer and leading cause of cancer death among women worldwide but has patterns and trends which vary in different countries. This study aimed to evaluate the global patterns of breast cancer incidence and mortality and analyze its temporal trends for breast cancer prevention and control.Methods: Breast cancer incidence and mortality data in 2020 were obtained from the GLOBOCAN online database. Continued data from the Cancer Incidence in Five Continents Time Trends, the International Agency for Research on cancer mortality and China National Central Cancer Registry were used to analyze the time trends from 2000 to 2015 through Joinpoint regression, and annual average percent changes of breast cancer incidence and mortality were calculated. Association between Human Development Index and breast cancer incidence and mortality were estimated by linear regression. Results: There were approximately 2.3 million new breast cancer cases and 685,000 breast cancer deaths worldwide in 2020. Its incidence and mortality varied among countries, with the age-standardized incidence ranging from the highest of 112.3 per 100,000 population in Belgium to the lowest of 35.8 per 100,000 population in Iran, and the age-standardized mortality from the highest of 41.

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“…At present, breast cancer is the most commonly diagnosed female malignancy worldwide and one of the most frequent causes of cancer-related death among women (reviewed in [ 1 , 2 ]). Recent epidemiological data show that after the lung cancer, breast cancer is the second most common malignancy overall.…”

“…Recent epidemiological data show that after the lung cancer, breast cancer is the second most common malignancy overall. According to the GLOBOCAN online database, there were about 2.3 million newly diagnosed female breast cancer cases and 685,000 breast cancer deaths worldwide in 2020 [ 2 ]. Such sad statistics delineate breast cancer as one of the greatest threats to modern humanity, so many physicians, pharmacologists and researchers in clinics and laboratories worldwide currently aim their efforts at fighting this challenge.…”

“…Over the past decade, largely thanks to the thorough surveillance aimed at early diagnosis of breast cancer and advances in the tumor treatment, patient outcomes and prognoses of breast cancer have been somewhat improved [ 1 , 2 ]. Nevertheless, breast cancer still remains an extremely acute problem of modern medicine.…”

“…Nevertheless, breast cancer still remains an extremely acute problem of modern medicine. Besides the particularly serious cases of triple negative breast cancer, other subtypes of breast carcinomas may be complicated by the early metastasis spread in the lymph nodes and bones and also the tumor cell resistance to chemotherapy and radiotherapy [ 1 , 2 , 3 , 4 ].…”

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“…Currently, breast cancer is the most common cancer affecting women worldwide, and its incidence is steadily increasing with 2.3 million women being newly diagnosed each year [1]. While significant progress has been achieved in breast cancer care and treatment results remain better, unfortunately breast cancer remains the second leading cause of cancer mortality among women in all countries, with 685,000 deaths each year [2]. In Morocco, breast cancer is a major public health problem, According to the World Health Organization cancer registry "GLOBOCAN 2020"; 11747 (38.9% of all cancers) new cases were diagnosed [3].…”