Global microarray profiling identified<i>hsa_circ_0064428</i>as a potential immune-associated prognosis biomarker for hepatocellular carcinoma

Weng, Qiaoyou; Chen, Minjiang; Li, Maoquan; Yang, Zheng; Shao, Guoliang; Fan, Weijun; Xu, Ximing; Ji, Jiansong

doi:10.1136/jmedgenet-2018-105440

Cited by 54 publications

(41 citation statements)

References 52 publications

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“…With the rapid progression and wide application of high-throughput sequencing and microarray, the expression pattern of circRNAs in various human diseases are increasingly reported, and the dysregulated expressions of circRNAs are shown to contribute to the pathogenesis of various cancers [7,[9][10][11][14][15][16][17][18][19]. For instance, in hepatitis B-related HCC, 189 upregulated circRNAs and 37 downregulated circRNAs were found by circRNA microarray, and circRNA_100,338 is further validated to be associated with metastatic progression by acting as an endogenous sponge for miR-141-3p [7].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma

et al. 2020

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Background: This study aimed to explore the heterogeneity of circRNA expression pattern via microarray, and further evaluate the potential of 10 specific circRNAs as diagnostic and prognostic biomarkers in multiple myeloma (MM). Methods:In exploration stage (stage I), circRNA expression profiles were detected by the microarray in bone marrow plasma cells from 4 MM patients and 4 healthy controls (HCs), and bioinformatic analyses were performed. In validation stage (stage II), top 10 upregulated and top 10 downregulated circRNAs identified in stage I were detected in 60 MM patients and 30 HCs for further validation; the diagnostic and prognostic values of these circRNAs in MM patients were analyzed.Results: In stage I, 122 upregulated and 260 downregulated circRNAs were identified in MM patients compared with HCs. GO, KEGG and pathway enrichment analyses revealed that these circRNAs were implicated in neoplastic pathways such as MAPK and VEGF signaling pathways. In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls. Circ-PTK2 and circ-RNF217 were correlated with poor treatment response and survival, while circ-AFF2 predicted good treatment response and survival in MM patients. Conclusions:This study provides valuable reference for profound understanding about circRNA expression patterns in MM, and validates that circ-PTK2, circ-RNF217 and circ-AFF2 might serve as potential prognostic biomarkers in MM.

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Section: Discussionmentioning

confidence: 99%

Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma

et al. 2020

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“…Through validation assays, low hsa_circ_ 0064428 expression was found in HCC patients with high TILs and exhibited close correlation with overall survival, tumour size and metastasis in patients with HCC [101]. It can be concluded that hsa_circ_0064428 functioned as a novel immune-associated prognostic biomarker for HCC patients [101]. Programmed death-ligand 1/programmed death-1 (PD-L1/PD-1), as key immune checkpoints, can suppress the activation of T lymphocytes and increase the immune tolerance of tumour cells, thereby achieving tumour immune escape [102][103][104].…”

Section: Circrnas and Lymphocytesmentioning

confidence: 98%

“…Then, Weng et al performed global circRNA microarray between plasma of HCC patients with high TILs and low TILs [101]. Through validation assays, low hsa_circ_ 0064428 expression was found in HCC patients with high TILs and exhibited close correlation with overall survival, tumour size and metastasis in patients with HCC [101]. It can be concluded that hsa_circ_0064428 functioned as a novel immune-associated prognostic biomarker for HCC patients [101].…”

Section: Circrnas and Lymphocytesmentioning

confidence: 99%

Circular RNAs in the tumour microenvironment

Shuai

Gao

et al. 2020

Mol Cancer

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Background: Circular RNAs (circRNAs) are a new class of endogenous non-coding RNAs (ncRNAs) widely expressed in eukaryotic cells. Mounting evidence has highlighted circRNAs as critical regulators of various tumours. More importantly, circRNAs have been revealed to recruit and reprogram key components involved in the tumour microenvironment (TME), and mediate various signaling pathways, thus affecting tumourigenesis, angiogenesis, immune response, and metastatic progression.Main body of the abstract: In this review, we briefly introduce the biogenesis, characteristics and classification of circRNAs, and describe various mechanistic models of circRNAs. Further, we provide the first systematic overview of the interplay between circRNAs and cellular/non-cellular counterparts of the TME and highlight the potential of circRNAs as prospective biomarkers or targets in cancer clinics. Finally, we discuss the biological mechanisms through which the circRNAs drive development of resistance, revealing the mystery of circRNAs in drug resistance of tumours. Short conclusion:Deep understanding the emerging role of circRNAs and their involvements in the TME may provide potential biomarkers and therapeutic targets for cancer patients. The combined targeting of circRNAs and co-activated components in the TME may achieve higher therapeutic efficiency and become a new mode of tumour therapy in the future.

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“…A relatively shorter CAR-T cell persistence provides an opportunity to avoid serious side effects such as cytokine storm and on-target off-tumour toxicity. Weng et al 31 found that hsa_circ_0064428 could be recognised as a potential immune-associated prognosis biomarker for HCC. In a review article, Xia et al 32 introduced applications and advances of CRISPR-Cas9 in cancer immunotherapy.…”

mentioning

confidence: 99%

Cancer immunotherapy: challenges and clinical applications

Xia¹,

2018

J Med Genet

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Global microarray profiling identifiedhsa_circ_0064428as a potential immune-associated prognosis biomarker for hepatocellular carcinoma

Abstract: These findings together imply that could be considered as a potential HCC prognosis biomarker. Future in-depth research is required to further illustrate the involvement of in HCC tumourigenesis and metastasis.

Cited by 54 publications

References 52 publications

Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma

Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma

Circular RNAs in the tumour microenvironment

Cancer immunotherapy: challenges and clinical applications

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