Global longitudinal strain is superior to ejection fraction for detecting myocardial dysfunction in end-stage renal disease with hyperparathyroidism

Carrasco-Ruiz, Maria Fernanda; Ruiz-Rivera, Antonio; Soriano‐Ursúa, Marvin A.; Martinez-Hernandez, Carlos; Manuel‐Apolinar, Leticia; Castillo-Hernandez, Carmen; Guevara‐Balcazar, Gustavo; Farfán‐García, Eunice D.; Mejia-Ruiz, Ana; Rubio-Gayosso, Iván; Pérez-Capistran, Teresa

doi:10.4330/wjc.v14.i4.239

Cited by 5 publications

(3 citation statements)

References 56 publications

(49 reference statements)

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“…To our knowledge, no studies have evaluated the relationship between IL-1B and GLS in patients on maintenance HD. Some authors consider that GLS could be a better predictor of left ventricle systolic dysfunction compared to the ejection fraction measurement in patients on dialysis [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Novel Biomarkers in Evaluating Cardiac Function in Patients on Hemodialysis—A Pilot Prospective Observational Cohort Study

Chisavu,

Ivan,

Mihaescu

et al. 2024

Diagnostics

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Chronic kidney disease patients treated by hemodialysis present a high cardiovascular morbidity and mortality. There is an imperative need for novel biomarkers for identifying these patients and to offer possible therapeutically interventions. We performed a prospective observational cohort study on 77 patients in the period of October 2021–October 2023. We measured serum plasma levels of interleukin 1-beta, galectin 3, human suppression of tumorigenicity factor 2, bone morphogenetic protein 2 and fibroblastic growth factor 23 at the inclusion site. We evaluated the correlations of these biomarkers with cardiac function and structure evaluated by echocardiography. The mean age was 61.02 (±11.81) years, with 45 (56.2%) males and with a dialysis vintage of 4.95 (2.4–7.8) years. Median ejection fraction was 51 (43–54%), and more than two-thirds of the patients presented valvular calcifications. Overall mortality was 22%. Interleukin 1-beta was correlated positively with ejection fraction and global longitudinal strain and negatively with left atrium diameter and left ventricle telesystolic diameter. Galectin 3 values were negatively correlated with aortic valve fibrosis and mitral valve calcifications, and human suppression tumorigenicity factor 2 was negatively correlated with mitral valve calcifications. Some of these novel biomarkers could be used to better assess cardiovascular disease in patients on maintenance hemodialysis.

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Section: Discussionmentioning

confidence: 99%

Novel Biomarkers in Evaluating Cardiac Function in Patients on Hemodialysis—A Pilot Prospective Observational Cohort Study

Chisavu,

Ivan,

Mihaescu

et al. 2024

Diagnostics

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“…New and more useful quantification measures are being developed along with the abovementioned novel imaging techniques. For example, global longitudinal strain (measured via conventional 2-dimensional echocardiography) has been reported to be a more sensitive predictor of myocardial dysfunction in ESRD compared with LVEF [ 42 ].…”

Section: Screening and Diagnosismentioning

confidence: 99%

Implications of uremic cardiomyopathy for the practicing clinician: an educational review

et al. 2023

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Studies over recent years have redeveloped our understanding of uremic cardiomyopathy, defined as left ventricular hypertrophy, congestive heart failure, and associated cardiac hypertrophy plus other abnormalities that result from chronic kidney disease and are often the cause of death in affected patients. Definitions of uremic cardiomyopathy have conflicted and overlapped over the decades, complicating the body of published evidence, and making comparison difficult. New and continuing research into potential risk factors, including uremic toxins, anemia, hypervolemia, oxidative stress, inflammation, and insulin resistance, indicates the increasing interest in illuminating the pathways that lead to UC and thereby identifying potential targets for intervention. Indeed, our developing understanding of the mechanisms of UC has opened new frontiers in research, promising novel approaches to diagnosis, prognosis, treatment, and management. This educational review highlights advances in the field of uremic cardiomyopathy and how they may become applicable in practice by clinicians. Pathways to optimal treatment with current modalities (with hemodialysis and angiotensin-converting enzyme inhibitors) will be described, along with proposed steps to be taken in research to allow evidence-based integration of developing investigational therapies.

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“…However, HF is such a complex syndrome that no single marker can be used to classify those patients. Accumulating data from recent studies show that markers of contractility such as longitudinal strain[ 19 ] and cardiac power[ 20 ] outperform the LVEF. The incorporation of artificial intelligence (AI) in diagnostic modalities, outcome predictions, and management of HF (individualized precision medicine) constitutes a major development in the field of cardiovascular medicine.…”

Section: To the Editormentioning

confidence: 99%

Heart failure with reduced, mildly reduced, or preserved left ventricular ejection fraction: Has reasoning been lost?

Xanthopoulos¹,

Giamouzis²,

Skoularigis³

et al. 2022

WJC

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Left ventricular (LV) ejection fraction (LVEF), defined as LV stroke volume divided by end-diastolic volume, has been systematically used for the diagnosis, classification, and management of heart failure (HF) over the last three decades. HF is classified as HF with reduced LVEF, HF with midrange or mildly reduced LVEF, and HF with preserved LVEF using arbitrary, continuously changing LVEF cutoffs. A prerequisite for using this LVEF-based terminology is knowledge of the LVEF normal range, which is lacking and may lead to erroneous conclusions in HF, especially at the higher end of the LVEF spectrum.

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Global longitudinal strain is superior to ejection fraction for detecting myocardial dysfunction in end-stage renal disease with hyperparathyroidism

Cited by 5 publications

References 56 publications

Novel Biomarkers in Evaluating Cardiac Function in Patients on Hemodialysis—A Pilot Prospective Observational Cohort Study

Novel Biomarkers in Evaluating Cardiac Function in Patients on Hemodialysis—A Pilot Prospective Observational Cohort Study

Implications of uremic cardiomyopathy for the practicing clinician: an educational review

Heart failure with reduced, mildly reduced, or preserved left ventricular ejection fraction: Has reasoning been lost?

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