Global Longitudinal Strain for Detection of Cardiac Iron Overload in Patients with Thalassemia: A Meta-analysis of Observational Studies with Individual-Level Participant Data
Abstract:Background
Although cardiac magnetic resonance (CMR) is the most reliable tool for assessment of CIO in patients with thalassemia, it is not always readily available. Recent studies have explored the potential of GLS as an alternative for diagnosis of CIO. We aimed to investigate the efficacy of global longitudinal strain (GLS) for detection of cardiac iron level (CIO).
Methods
We searched SCOPUS, MEDLINE, and Embase to identify the studies which used GLS for assessment of CIO. We searched for individual par… Show more
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