Global liver transplantation: emerging trends and ethical challenges

Hill, Angela L.; Khan, Maryam; Kiani, Amen Z.; Lindemann, Jessica D.; Vachharajani, Neeta; Doyle, Majella B.; Chapman, William C.; Khan, Adeel S.

doi:10.1007/s00423-023-03144-4

Cited by 1 publication

(1 citation statement)

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“…In advanced HCC, liver transplantation is the standard treatment for end-stage liver disease (ESLD) (Hill et al, 2023). Studies have shown that women are less likely than men to receive LT because the hypothesis responsible for the gender-based variation in radical treatment is limited by the ability of Model for End-Stage Liver Disease (MELD) scores based on cr measurements in females (Mindikoglu et al, 2013;Karnam et al, 2021).…”

Section: Medical Treatment In Hccmentioning

confidence: 99%

Exploiting gender-based biomarkers and drug targets: advancing personalized therapeutic strategies in hepatocellular carcinoma

Su,

Luo,

Yan

et al. 2024

Front. Pharmacol.

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This review systematically examines gender differences in hepatocellular carcinoma (HCC), identifying the influence of sex hormones, genetic variance, and environmental factors on the disease’s epidemiology and treatment outcomes. Recognizing the liver as a sexually dimorphic organ, we highlight how gender-specific risk factors, such as alcohol consumption and obesity, contribute differently to hepatocarcinogenesis in men and women. We explore molecular mechanisms, including the differential expression of androgen and estrogen receptors, which mediate diverse pathways in tumor biology such as cell proliferation, apoptosis, and DNA repair. Our analysis underscores the critical need for gender-specific research in liver cancer, from molecular studies to clinical trials, to improve diagnostic accuracy and therapeutic effectiveness. By incorporating a gender perspective into all facets of liver cancer research, we advocate for a more precise and personalized approach to cancer treatment that acknowledges gender as a significant factor in both the progression of HCC and its response to treatment. This review aims to foster a deeper understanding of the biological and molecular bases of gender differences in HCC and to promote the development of tailored interventions that enhance outcomes for all patients.

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Section: Medical Treatment In Hccmentioning

confidence: 99%