Global Increasing Incidence of Young-Onset Colorectal Cancer Across 5 Continents: A Joinpoint Regression Analysis of 1,922,167 Cases

Lui, Rashid; Tsoi, Kelvin K.F.; Ho, Man-Wai; Lo, Chuiman; Chan, Felix C.H.; Kyaw, Moe H.; Sung, Joseph J.Y.

doi:10.1158/1055-9965.epi-18-1111

Cited by 93 publications

(74 citation statements)

References 31 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the absolute risk of CRC in adults younger than 50 years is low relative to older adults, disease trends in young age groups are a key indicator of recent changes in risk factor exposures and often foreshadow the future cancer burden 10. In addition to country-specific analyses, there are recent reports on early-onset CRC occurrence in seven high-income countries,11 in Europe12 and in 11 ‘industrialised’ countries (data through 2007) 13. However, a comprehensive examination of contemporary trends on a global scale is lacking.…”

Section: Introductionmentioning

confidence: 99%

Global patterns and trends in colorectal cancer incidence in young adults

Siegel

Torre

Soerjomataram

et al. 2019

Gut

503

417

View full text Add to dashboard Cite

ObjectiveEarly-onset colorectal cancer (CRC) is increasing in the USA despite rapid declines in older ages. Similar patterns are reported in Australia and Canada, but a comprehensive global analysis of contemporary data is lacking.DesignWe extracted long-term data from Cancer Incidence in Five Continents and supplemental sources to report on worldwide CRC incidence rates and trends by age (20–49 years and ≥50 years) through diagnosis year 2012 or beyond (Australia, Finland, New Zealand, Norway, Sweden, USA).ResultsDuring 2008–2012, age-standardised CRC incidence rates in adults <50 ranged from 3.5 per 100 000 (95% CI 3.2 to 3.9) in India (Chennai) to 12.9 (95% CI 12.6 to 13.3) in Korea. During the most recent decade of available data, incidence in adults <50 was stable in 14 of 36 countries; declined in Austria, Italy and Lithuania; and increased in 19 countries, nine of which had stable or declining trends in older adults (Australia, Canada, Denmark, Germany, New Zealand, Slovenia, Sweden, UK and USA). In Cyprus, Netherlands and Norway, inclines in incidence in young adults were twice as rapid as those in older adults (eg, Norway average annual per cent change (AAPC), 1.9 (95% CI 1.4 to 2.5) vs 0.5 (95% CI 0.3 to 0.7)). Among most high-income countries with long-term data, the uptick in early-onset disease began in the mid-1990s. The steepest increases in young adults were in Korea (AAPC, 4.2 (95% CI 3.4 to 5.0)) and New Zealand (AAPC, 4.0 (95% CI 2.1 to 6.0)).ConclusionCRC incidence increased exclusively in young adults in nine high-income countries spanning three continents, potentially signalling changes in early-life exposures that influence large bowel carcinogenesis.

show abstract

Section: Introductionmentioning

confidence: 99%

Global patterns and trends in colorectal cancer incidence in young adults

Siegel

Torre

Soerjomataram

et al. 2019

Gut

503

417

View full text Add to dashboard Cite

show abstract

“…Traditionally a disease of the elderly, colorectal cancer (CRC) incidence in the young is steadily rising across the globe [1,2]. In contrast, the incidence of CRC in older patients is seeing a progressive decrease in the developed world, which is likely to be attributed to population-based CRC screening [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics

et al. 2020

View full text Add to dashboard Cite

Background: Colorectal cancer (CRC) in patients aged under 55 years is on the rise, constituting approximately 10% of cases. Our aim was to determine the survival and clinico-pathological details of young-onset CRC (yCRC), as well as audit the referral rate to genetic services and thus establish the incidence of inherited cancer syndromes. Methods: A retrospective case note review was conducted for patients aged under 55 years who were diagnosed with CRC between 2005 and 2015 in the North East of Scotland. Cases were identified by pathology records and data was obtained from patient notes. Analysis was performed using SPSS version 25 (IBM, New York, USA) to produce Kaplan-Meier survival estimates, descriptive statistics and markers predictive for genetic referral.Results: Data from 345 patients (age range 22-54 years) were identified. The one year, five year and overall survival rates were found to be 89, 63 and 55%, respectively. Most patients (61%) presented with advanced disease. Of 201 patients that met criteria for genetic referral, only 93 (46%) were referred to genetic services. Microsatellite instability (MSI) was identified in 14% of those referred. Conclusion: Survival in yCRC was found to be better than that in later onset disease, despite higher rates of advanced disease. Patients were under-referred to genetic services, where a significant proportion were found to be MSI positive and investigated for Lynch syndrome.

show abstract

“…The global increasing incidence of young-onset colorectal cancer has been noted to include a prominent rise in rectal cancer when compared to colon cancer [27]. Persistent HPV high-risk infection is clearly linked to anal and rectal cancer [28].…”

Section: How Can the Virome Induce Carcinogenesis?mentioning

confidence: 99%

Enteric Virome and Carcinogenesis in the Gut

Emlet

Lamendella

2020

Dig Dis Sci

View full text Add to dashboard Cite

Colorectal cancer (CRC) is a leading cause of cancer-related deaths in both the USA and the world. Recent research has demonstrated the involvement of the gut microbiota in CRC development and progression. Microbial biomarkers of disease have focused primarily on the bacterial component of the microbiome; however, the viral portion of the microbiome, consisting of both bacteriophages and eukaryotic viruses, together known as the virome, has been lesser studied. Here we review the recent advancements in high-throughput sequencing (HTS) technologies and bioinformatics, which have enabled scientists to better understand how viruses might influence the development of colorectal cancer. We discuss the contemporary findings revealing modulations in the virome and their correlation with CRC development and progression. While a variety of challenges still face viral HTS detection in clinical specimens, we consider herein numerous next steps for future basic and clinical research. Clinicians need to move away from a single infectious agent model for disease etiology by grasping new, more encompassing etiological paradigms, in which communities of various microbial components interact with each other and the host. The reporting and indexing of patient health information, socioeconomic data, and other relevant metadata will enable identification of predictive variables and covariates of viral presence and CRC development. Altogether, the virome has a more profound role in carcinogenesis and cancer progression than once thought, and viruses, specific for either human cells or bacteria, are clinically relevant in understanding CRC pathology, patient prognosis, and treatment development.

show abstract

Global Increasing Incidence of Young-Onset Colorectal Cancer Across 5 Continents: A Joinpoint Regression Analysis of 1,922,167 Cases

Cited by 93 publications

References 31 publications

Global patterns and trends in colorectal cancer incidence in young adults

Global patterns and trends in colorectal cancer incidence in young adults

Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics

Enteric Virome and Carcinogenesis in the Gut

Contact Info

Product

Resources

About