Global Host Immune Response: Pathogenesis and Transcriptional Profiling of Type A Influenza Viruses Expressing the Hemagglutinin and Neuraminidase Genes from the 1918 Pandemic Virus

Kash, John C.; Basler, Christopher F.; Garcı́a-Sastre, Adolfo; Carter, Victoria; Billharz, Rosalind; Swayne, David E.; Przygodzki, Ronald; Taubenberger, Jeffery K.; Katze, Michael G.; Tumpey, Terrence M.

doi:10.1128/jvi.78.17.9499-9511.2004

Cited by 156 publications

(150 citation statements)

References 70 publications

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“…Within a larger perspective, studies have demonstrated that several hundred genes are up-regulated shortly after a flu infection (39,40). There are no similar data available to date for HDMelicited immune-inflammatory responses, although a similarly rich array of gene up-regulation would be expected given the immunogenic potential of HDM extracts (30 -32).…”

Section: Discussionmentioning

confidence: 99%

Acute, but Not Resolved, Influenza A Infection Enhances Susceptibility to House Dust Mite-Induced Allergic Disease

Al-Garawi

Fattouh

Walker

et al. 2009

The Journal of Immunology

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The impact of respiratory viral infections on the emergence of the asthmatic phenotype is a subject of intense investigation. Most experimental studies addressing this issue have used the inert Ag OVA with controversial results. We examined the consequences of exposure to a low dose of the common aeroallergen house dust mite (HDM) during the course of an influenza A infection. First, we delineated the kinetics of the immune-inflammatory response in the lung of mice following intranasal infection with influenza A/PR8/34. Our data demonstrate a peak response during the first 10 days, with considerable albeit not complete resolution at day 39 postinfection (p.i.). At day 7 p.i., mice were exposed, intranasally, to HDM for 10 consecutive days. We observed significantly enhanced eosinophilic inflammation, an expansion in Th2 cells, enhanced HDM-specific IgE and IgG1 responses and increased mucous production. Furthermore, lung mononuclear cells produced enhanced IFN-␥ and IL-5, unchanged IL-13, and reduced IL-4. These immunologic and structural changes lead to marked lung dysfunction. This allergic phenotype occurs at a time when there is a preferential increase in plasmacytoid dendritic cells over myeloid dendritic cells, activated CD8؉ T cells, and increased IFN-␥ production, all of which have been proposed to inhibit allergic responses. In contrast, the inflammatory response elicited by HDM was reduced when exposure occurred during the resolution phase (day 40 p.i.). Interestingly, this was not associated with a reduction in sensitization. Thus, the proinflammatory environment established during an acute influenza A infection enhances Th2-polarized immunity to a low dose of HDM and precipitates marked lung dysfunction.

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Section: Discussionmentioning

confidence: 99%

Acute, but Not Resolved, Influenza A Infection Enhances Susceptibility to House Dust Mite-Induced Allergic Disease

Al-Garawi

Fattouh

Walker

et al. 2009

The Journal of Immunology

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“…[126][127][128] BALB/c mice infected with r1918 had more severe weight loss, an earlier mean time of death, and viral titers of lung tissue 10-fold higher on days 1 and 3 compared to mice infected with other viral strains. 129 Gene expression studies confirmed that the virulence correlated with the early and increased expression of immune response-related genes in r1918 infection.…”

Section: Studies With Recombinant Influenza Virusmentioning

confidence: 99%

Influenza, Immune System, and Pregnancy

2014

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Influenza is a major health problem worldwide. Both seasonal influenza and pandemics take a major toll on the health and economy of our country. The present review focuses on the virology and complex immunology of this RNA virus in general and in relation to pregnancy. The goal is to attempt to explain the increased morbidity and mortality seen in infection during pregnancy. We discuss elements of innate and adaptive immunity as well as placental cellular responses to infection. In addition, we delineate findings in animal models as well as human disease. Increased knowledge of maternal and fetal immunologic responses to influenza is needed. However, enhanced understanding of nonimmune, pregnancy-specific factors influencing direct interaction of the virus with host cells is also important for the development of more effective prevention and treatment options in the future.

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“…The genes specifically getting up-regulated in response to virus infection were interferon inducible genes, pro-inflammatory cytokines, components of JAK-STAT pathway, NF-ĸB mediated signaling and genes involved in apoptotic mechanism [32][33][34]41,42]. Interactions of these genes with various other proteins involved in signal transduction mechanism have also been elucidated in these studies.…”

Section: Study Of Host Cellular Responses To Influenza a Infection Usmentioning

confidence: 90%

“…High-density microarray-based analysis of mRNA expression and single nucleotide polymorphisms are providing unprecedented ways to analyze the diversity of the genomes of influenza viruses as well as the molecular basis of the host response to them [4,31,32].…”

Section: Study Of Host Cellular Responses To Influenza a Infection Usmentioning

confidence: 99%

Impact of Microarray Technology in Influenza Virus Research and Diagnostics

Mukherjee¹

2013

J Proteomics Bioinform

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Global Host Immune Response: Pathogenesis and Transcriptional Profiling of Type A Influenza Viruses Expressing the Hemagglutinin and Neuraminidase Genes from the 1918 Pandemic Virus

Cited by 156 publications

References 70 publications

Acute, but Not Resolved, Influenza A Infection Enhances Susceptibility to House Dust Mite-Induced Allergic Disease

Acute, but Not Resolved, Influenza A Infection Enhances Susceptibility to House Dust Mite-Induced Allergic Disease

Influenza, Immune System, and Pregnancy

Impact of Microarray Technology in Influenza Virus Research and Diagnostics

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