Global Healthspan Summit 2023: closing the gap between healthspan and lifespan

Khan, Mehmood; Al Saud, Haya; Sierra, Felipe; Perez, Viviana; Greene, William; Al Asiry, Salman; Pathai, Sophia; Torres, Michael

doi:10.1038/s43587-024-00593-4

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…However, the corresponding healthy life expectancy, defined as years lived in full health since birth, has failed to keep up the pace 1 . The gap between healthspan and lifespan highlights a substantial challenge posed by chronic diseases among older adults 2 , emphasizing the need for novel approaches to narrow the gap and prolong disease-free longevity 3 . The geroscience approach is a potential solution, addressing the hypothesis that targeting the hallmarks of aging, rather than individual diseases of aging, may prevent or delay the onset of multiple age-related conditions 4 .…”

Section: Mainmentioning

confidence: 99%

A proteomic signature of healthspan

Kuo,

Liu,

Chen

et al. 2024

Preprint

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The focus of aging research has shifted from increasing lifespan to enhancing healthspan to reduce the time spent living with disability. Despite significant efforts to develop biomarkers of aging, few studies have focused on biomarkers of healthspan. We developed a proteomics-based signature of healthspan (healthspan proteomic score (HPS)) using data from the UK Biobank Pharma Proteomics Project (53,018 individuals and 2920 proteins). A lower HPS was associated with higher mortality risk and several age-related conditions, such as COPD, diabetes, heart failure, cancer, myocardial infarction, dementia, and stroke. HPS showed superior predictive accuracy for these outcomes compared to chronological age and biological age measures. Proteins associated with HPS were enriched in hallmark pathways such as immune response, inflammation, cellular signaling, and metabolic regulation. Our findings demonstrate the validity of HPS, making it a valuable tool for assessing healthspan and as a potential surrogate marker in geroscience-guided studies.

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Section: Mainmentioning

confidence: 99%