Global health and the US Centers for Disease Control and Prevention

Schuchat, Anne; Tappero, Jordan W.; Blandford, John M.

doi:10.1016/s0140-6736(14)60570-5

Cited by 12 publications

(7 citation statements)

References 19 publications

(22 reference statements)

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“…With the large number and irrational abuse of antibacterial drugs, the drug resistance rate of K. pneumoniae continues to increase (19). The US Centers for Disease Control and Prevention listed Krk-resistant pneumococcus pneumoniae (CRKP) as the highest urgent grade in 2013 (20). Moreover, the World Health Organization mentioned CRKP in the global drug resistance surveillance report (21).…”

Section: Discussionmentioning

confidence: 99%

Klebsiella pneumoniae infection inhibits autophagy by alveolar type�II epithelial cells

Zhang

et al. 2020

Exp Ther Med

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To investigate the molecular mechanism underlying the interaction between autophagosomes of alveolar type II epithelial (A549) cells and Klebsiella pneumoniae, an in vitro model of K. pneumoniae-infected A549 cells was established. Western blot analysis and immunofluorescence staining were used to detect the distribution of microtubule-associated protein 1A/1B-light chain 3 (LC3) and the expression of the LC3-phosphatidylethanolamine conjugate (LC3-II). K. pneumoniae-infected A549 cells were treated with different concentrations of an autophagy inhibitor or promoter for different time periods to assess the level of autophagy. Western blot analysis and immunofluorescence staining showed that K. pneumoniae could induce autophagy by A549 cells. With an increase in bacterial concentration and time of infection, autophagy gradually increased. The autophagy inhibitor significantly downregulated, while the promoter upregulated, expression of the autophagy-related protein LC3-II. Autophagy plays an important role in the resistance of alveolar type II epithelial (A549) cells to K. pneumoniae infection. Materials and methods Bacterial strain and cell type. The reference strain K. pneumoniae K6 (ATCC 700603) was obtained from the American Type Culture Collection and preserved in our laboratory. A549 cells are hypotriploid alveolar basal epithelial

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Section: Discussionmentioning

confidence: 99%

Klebsiella pneumoniae infection inhibits autophagy by alveolar type�II epithelial cells

Zhang

et al. 2020

Exp Ther Med

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“…Although the threat of Ebola importation contributed to preparation of an effective response, the other countries already had components of the GHSA in place, and although not fully developed it showed that even nascent capacity was crucial in facilitation of a timely response. In Nigeria, a dedicated public health emergency operations centre for polio eradication and a cadre of Field Epidemiology Training Program-trained 56 epidemiologists facilitated the multisectoral coordination and extensive contact tracing efforts needed to control the outbreak once it spread as it spread within Lagos, and from Lagos to a second city. 51 A common theme in quelling the Ebola importation events has been the ready availability of trained ministry of health staff who used existing surveillance systems, laboratories, and public health emergency operations capabilities to quickly control Ebola.…”

Section: Global Health Security Agenda: Building Resilient Public Heamentioning

confidence: 99%

Global health security: the wider lessons from the west African Ebola virus disease epidemic

Heymann

Chen

Takemi³

et al. 2015

The Lancet

454

352

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The Ebola virus disease outbreak in West Africa was unprecedented in both its scale and impact. Out of this human calamity has come renewed attention to global health security—its definition, meaning, and the practical implications for programmes and policy. For example, how does a government begin to strengthen its core public health capacities, as demanded by the International Health Regulations? What counts as a global health security concern? In the context of the governance of global health, including WHO reform, it will be important to distil lessons learned from the Ebola outbreak. The Lancet invited a group of respected global health practitioners to reflect on these lessons, to explore the idea of global health security, and to offer suggestions for next steps. Their contributions describe some of the major threats to individual and collective human health, as well as the values and recommendations that should be considered to counteract such threats in the future. Many different perspectives are proposed. Their common goal is a more sustainable and resilient society for human health and wellbeing.

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“…1 As a whole, the monitoring of and helping to maintain the health of populations, including but not restricted to the United States, requires a multiplicity of public and private institutions and a variety of professional fields to ensure it is working toward its most effective state possible. 2 As with all potentially fragile entities, the health of the American public requires a security system for it to remain viable. 3 Examples of how commonly this philosophy is held can be found in the expansive use of security-focused terms regarding public health.…”

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confidence: 99%

The Potential Impact of Border Security Upon Prevalence of Infectious Disease

Dallas

Harris

Dallas

2018

Disaster med. public health prep.

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In the U.S., migration has been documented to affect the prevalence of infectious disease. As a mitigation entity, border security has been recorded by numerous scholarly works as being essential to the support of the health of the U.S. population. Consequently, the lack of current health care monitoring of the permeable U.S. border places the U.S. population at risk in the broad sectors of infectious disease and interpersonal violence. Visualizing border security in the context of public health mitigation has significant potential to protect migrant health as well as that of all populations on both sides of the border. Examples of how commonly this philosophy is held can be found in the expansive use of security-focused terms regarding public health. Using tools such as GIS to screen for disease in people before their entrance into a nation would be more efficient and ethical than treating patients once they have entered a population and increased the impact on the healthcare system. (Disaster Med Public Health Preparedness. 2018;12:554-562).

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Global health and the US Centers for Disease Control and Prevention

Cited by 12 publications

References 19 publications

Klebsiella pneumoniae infection inhibits autophagy by alveolar type�II epithelial cells

Klebsiella pneumoniae infection inhibits autophagy by alveolar type�II epithelial cells

Global health security: the wider lessons from the west African Ebola virus disease epidemic

The Potential Impact of Border Security Upon Prevalence of Infectious Disease

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