Global Functional Connectivity Analysis Indicating Dysconnectivity of the Hate Circuit in Major Depressive Disorder

Pan, Pan; Wang, Lu; Wu, Chujun; Jin, Kun; Cao, Song; Qiu, Yan; Teng, Ziwei; Li, Sujuan; Shao, Tiannan; Huang, Jing; Wu, Haishan; Xiang, Hui; Chen, Jindong; Liu, Feng; Tang, Hui; Guo, Wenbin

doi:10.3389/fnagi.2021.803080

Cited by 4 publications

(2 citation statements)

References 65 publications

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“…Compared with HCs, MDD patients were reported to have increased ReHo values in the SMA (Liu et al, 2012;Yan et al, 2021). A previous study discovered significantly higher FC in SMA in MDD patients (Pan et al, 2021). Researchers in treatment-resistant MDD have shown that SMA hypometabolism had active response to antidepressant medication (Jiang et al, 2018).…”

Section: Discussionmentioning

confidence: 94%

Neural activity changes in first-episode, drug-naïve patients with major depressive disorder after transcutaneous auricular vagus nerve stimulation treatment: A resting-state fMRI study

Wang²,

Yang³

et al. 2022

Front. Neurosci.

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IntroductionMajor depressive disorder (MDD) is a disease with prominent individual, medical, and economic impacts. Drug therapy and other treatment methods (such as Electroconvulsive therapy) may induce treatment-resistance and have associated side effects including loss of memory, decrease of reaction time, and residual symptoms. Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel and non-invasive treatment approach which stimulates brain structures with no side-effects. However, it remains little understood whether and how the neural activation is modulated by taVNS in MDD patients. Herein, we used the regional homogeneity (ReHo) to investigate the brain activity in first-episode, drug-naïve MDD patients after taVNS treatment.Materials and methodsTwenty-two first-episode, drug-naïve MDD patients were enrolled in the study. These patients received the first taVNS treatment at the baseline time, and underwent resting-state MRI scanning twice, before and after taVNS. All the patients then received taVNS treatments for 4 weeks. The severity of depression was assessed by the 17-item Hamilton Depression Rating Scale (HAMD) at the baseline time and after 4-week’s treatment. Pearson analysis was used to assess the correlation between alterations of ReHo and changes of the HAMD scores. Two patients were excluded due to excessive head movement, two patients lack clinical data in the fourth week, thus, imaging analysis was performed in 20 patients, while correlation analysis between clinical and imaging data was performed in only 18 patients.ResultsThere were significant differences in the ReHo values in first-episode, drug-naïve MDD patients between pre- or post- taVNS. The primary finding is that the patients exhibited a significantly lower ReHo in the left/right median cingulate cortex, the left precentral gyrus, the left postcentral gyrus, the right calcarine cortex, the left supplementary motor area, the left paracentral lobule, and the right lingual gyrus. Pearson analysis revealed a positive correlation between changes of ReHo in the right median cingulate cortex/the left supplementary motor area and changes of HAMD scores after taVNS.ConclusionThe decreased ReHo were found after taVNS. The sensorimotor, limbic and visual-related brain regions may play an important role in understanding the underlying neural mechanisms and be the target brain regions in the further therapy.

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Section: Discussionmentioning

confidence: 94%

Neural activity changes in first-episode, drug-naïve patients with major depressive disorder after transcutaneous auricular vagus nerve stimulation treatment: A resting-state fMRI study

Wang²,

Yang³

et al. 2022

Front. Neurosci.

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“…Moreover, the global functional connectivity density (gFCD) calculates the ratio of FC values to the voxels in different brain regions, eliminating the impact of differences in the brain area volume on FC ( Pan et al, 2022 ). The calculation method for local functional connectivity density (lFCD) is similar to that of gFCD, which represents the ratio of SC values to voxels in the brain regions ( Jia et al, 2018 ).…”

Section: Methodsmentioning

confidence: 99%

Differences in the distribution of triggers among resting state networks in patients with juvenile myoclonic epilepsy explained by network analysis

Luo,

Liu,

Zhang

et al. 2023

Front. Neurosci.

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BackgroundJuvenile myoclonus epilepsy (JME) is an idiopathic generalized epilepsy syndrome. Functional connectivity studies based on graph theory have demonstrated changes in functional connectivity among different brain regions in patients with JME and healthy controls. However, previous studies have not been able to clarify why visual stimulation or increased cognitive load induces epilepsy symptoms in only some patients with JME.MethodsThis study constructed a small-world network for the visualization of functional connectivity of brain regions in patients with JME, based on system mapping. We used the node reduction method repeatedly to identify the core nodes of the resting brain network of patients with JME. Thereafter, a functional connectivity network of the core brain regions in patients with JME was established, and it was analyzed manually with white matter tracks restriction to explain the differences in symptom distribution in patients with JME.ResultsPatients with JME had 21 different functional connections in their resting state, and no significant differences in their distribution were noted. The thalamus, cerebellum, basal ganglia, supplementary motor area, visual cortex, and prefrontal lobe were the core brain regions that comprised the functional connectivity network in patients with JME during their resting state. The betweenness centrality of the prefrontal lobe and the visual cortex in the core functional connectivity network of patients with JME was lower than that of the other brain regions.ConclusionThe functional connectivity and node importance of brain regions of patients with JME changed dynamically in the resting state. Abnormal discharges originating from the thalamus, cerebellum, basal ganglia, supplementary motor area, visual cortex, and prefrontal cortex are most likely to lead to seizures in patients with JME. Further, the low average value of betweenness centrality of the prefrontal and visual cortices explains why visual stimulation or increased cognitive load can induce epileptic symptoms in only some patients with JME.

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SS-31 Improves Cognitive Function in Sepsis-Associated Encephalopathy by Inhibiting the Drp1-NLRP3 Inflammasome Activation

Zhong

Ren

et al. 2022

Neuromol Med

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Global Functional Connectivity Analysis Indicating Dysconnectivity of the Hate Circuit in Major Depressive Disorder

Cited by 4 publications

References 65 publications

Neural activity changes in first-episode, drug-naïve patients with major depressive disorder after transcutaneous auricular vagus nerve stimulation treatment: A resting-state fMRI study

Neural activity changes in first-episode, drug-naïve patients with major depressive disorder after transcutaneous auricular vagus nerve stimulation treatment: A resting-state fMRI study

Differences in the distribution of triggers among resting state networks in patients with juvenile myoclonic epilepsy explained by network analysis

SS-31 Improves Cognitive Function in Sepsis-Associated Encephalopathy by Inhibiting the Drp1-NLRP3 Inflammasome Activation

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