Global estimates of undiagnosed diabetes in adults

Beagley, Jessica; Guariguata, Leonor; Weil, Clara; Motala, Ayesha A.

doi:10.1016/j.diabres.2013.11.001

Cited by 462 publications

(348 citation statements)

References 28 publications

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“…Global estimates indicate that 382 million people live with DM (8.3%), and this number could reach 592 million by 2035 1 . Approximately 50.0% of patients with diabetes are believed to be unaware of their condition 2 . With regard to mortality, it is estimated that 5.1 million people between the age of 20 and 79 years died of diabetes in 2013 3 .…”

Section: Introductionmentioning

confidence: 99%

Prevalência de diabetes mellitus e fatores associados na população adulta brasileira: evidências de um inquérito de base populacional

Flor

Campos

2017

Rev. bras. epidemiol.

148

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ABSTRACT:Objective: To estimate the prevalence of self-reported diabetes mellitus (DM) and its associated factors among the Brazilian adult population. Methods: The prevalence of DM was assessed in the Survey on Social Dimensions of Inequalities, a national survey with macro-regions representativeness carried out in 2008. Data were collected by a personal face-to-face interview with 12,423 individuals of both sexes, aged over 20 years. The χ 2 test at 5.0% was performed in order to identify associated factors, and logistic regression was used to estimate adjusted odds ratios. Results: The prevalence of DM in Brazil was 7.5%. After adjusting for potential confounders, diabetes remained associated with age (≥ 40 years), education (< 8 years of study), marital status (non-married), obesity, sedentary lifestyle, comorbidity with hypertension and hypercholesterolemia, as well as the demand for health services. Conclusion: Results indicate a high prevalence of DM and its associated preventable factors in Brazil. Thus, they highlight the need for a behavioral change as a strategy for prevention and control of diabetes and its complications.

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Section: Introductionmentioning

confidence: 99%

Prevalência de diabetes mellitus e fatores associados na população adulta brasileira: evidências de um inquérito de base populacional

Flor

Campos

2017

Rev. bras. epidemiol.

148

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“…The overall effect is hyperglycaemia which leads to serious complications and even death. DM has a prevalence rate of about 8.3% affecting around 387 million people worldwide with many especially in Africa undiagnosed (Guariguata et al 2014; Beagley et al 2014). Death rate due to DM is about 2.7% of all death cases, and it is suspected a major contributor to ischaemic heart disease and stroke (Almdal et al 2004), the top two leading causes of death worldwide (World Health Organization 2014).…”

Section: Introductionmentioning

confidence: 99%

Hexane Extract of Dacryodes Edulis Fruits Possesses Anti-Diabetic and Hypolipidaemic Potentials in Alloxan Diabetes of Rats.

Okolo¹,

Ejere²,

Chukwuka³

et al. 2016

Afr J Tradit Complement Altern Med

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Background: The fruit extract of Dacryodes edulis (D. edulis), the African pear or plum, a tree indigenous to the humid tropics has been used for managing wounds, skin diseases, sickle cell anaemia, dysentery and fever in some African nations. In South Eastern Nigeria, 'herbal doctors' include its marshed fruit in decoctions administered to diabetic patients. However no scientific substantiation of their claim and use exist in literature. Hence, the need to evaluate the antidiabetic and hypolipidaemic activity of hexane extracts of D. edulis fruit in alloxanised animal model. Materials and Methods: Sub-toxic doses between 400 and 1600mg/kg were orally administered sub-chronically to alloxan-induced diabetic rats for 15 days and compared to glibenclamide (2.5mg/kg). The glycaemia levels, body weights, lipid profile, blood urea, creatinine and liver enzyme levels were measured. Basic histology of the pancreatic tissue was also performed to examine the effects on the pancreas as possible mechanistic lead. Results: Oral acute dosing of D. edulis hexane extract decreased blood glucose levels, while sub-chronic treatment of the extract down-regulated significantly hyperglycaemia, total cholesterol, triglycerides, LDL-C, ALT and ALP levels. However, the HDL-C levels increased significantly. Histopathological examination of the pancreatic tissues after sub-chronic treatment showed that glibenclamide and the highest dose of the extract 1600mg/kg restored the afore-damaged pancreatic β-cell architecture. Conclusion: Our findings portend that D. edulis hexane fruit extract possesses hypoglycaemic and hypolipidaemic activities as well as restoration of the pancreatic architecture without any obvious untoward hepatic damages, suggesting that its use in the management of the diabetes may be valid.

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“…Diabetes mellitus (DM) is considered as one of the most challenging public health concerns, as globally 422 million adults were living with diabetes in 2014, compared to 108 million in 1980 [1,2]. The global prevalence of diabetes has nearly doubled since 1980, rising from 4.7% to 8.5% in the adult population [2].…”

Section: Introductionmentioning

confidence: 99%