Global epidemiology of leprosy from 2010 to 2020: A systematic review and meta-analysis of the proportion of sex, type, grade 2 deformity and age

Yang, Jing; Li, Xiang; Yan-qi, Sun; Zhang, Lianhua; Jin, Guangjie; Li, Guoli; Zhang, Shunyu; Hou, Kunchi; Li, Yunhui

doi:10.1080/20477724.2022.2057722

Cited by 5 publications

(2 citation statements)

References 47 publications

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“…The median length of leprosy in the subjects of this study was 12 to 24 months. An observational study stated that the duration of patients suffering from leprosy was on average above 12 months (Kementerian Kesehatan Republik Indonesia, 2023; Nazli et al, 2021;Ramasamy et al, 2018;Yang et al, 2022Yang et al, , 2022Yang et al, , 2022. Another study mentioned episodes of leprosy reactions more than four times in 48 subjects with a period of more than 12 months (Putri et al, 2022).…”

Section: Methodsmentioning

confidence: 99%

Effect of Curcuma longa Extract as Adjuvant Therapy on IL-6 Serum Levels in Leprosy Type 1 Reaction Patients

Putri,

Mundhofir,

Yuniati

et al. 2024

JHS

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Type 1 leprosy reaction / Reversal reaction (RR) is an inflammatory episode in existing leprosy lesions and aggravates the pain rate. Long-term therapy with steroids causes a variety of side effects, so an adjuvant therapy alternative is needed to alleviate steroid use. Curcuma longa rhizome extract has become an anti-inflammatory therapy choice in various previous inflammatory diseases. This study aims to determine the anti-inflammatory effect of Curcuma longa rhizome extract as an adjuvant therapy for reversal reaction patients by analyzing serum levels of IL-6 as a marker of inflammation. The pre and post-test randomized single-blinded controlled trial was conducted on two groups, namely control (RR patients with steroid therapy & placebo) and treatment (steroid therapy & Curcuma longa rhizome extract 1 gram/day). IL-6 serum levels were analyzed from sampling before and after the intervention for one month. The serum levels of IL-6 post-test in the control group were significantly higher than those of the pre-test. The treatment group showed lower serum levels of IL-6 post-test compared to pre-test, although there was no significant difference. Curcuma longa rhizome extract 1 gram/day for one month as adjuvant therapy for patients with type 1 leprosy reaction did not significantly reduce serum IL-6 levels.

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Section: Methodsmentioning

confidence: 99%

Effect of Curcuma longa Extract as Adjuvant Therapy on IL-6 Serum Levels in Leprosy Type 1 Reaction Patients

Putri,

Mundhofir,

Yuniati

et al. 2024

JHS

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“…This includes implementing initiatives to identify cases and contacts in regions with elevated HD detection rates, often referred to as HD hotspots, with prior education campaigns at community level. In addition, the evaluation of diagnostic tools such as antibody detection and molecular techniques is particularly valuable in identifying multibacillary cases, which account for approximately 69% of new HD cases globally (12).…”

Section: Potential Role Of Ai In Hd Programsmentioning

confidence: 99%

The potential role of artificial intelligence in the clinical management of Hansen’s disease (leprosy)

Deps,

Yotsu,

Furriel

et al. 2024

Front. Med.

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Missed and delayed diagnoses of Hansen’s disease (HD) are making the battle against it even more complex, increasing its transmission and significantly impacting those affected and their families. This strains public health systems and raises the risk of lifelong impairments and disabilities. Worryingly, the three countries most affected by HD witnessed a growth in new cases in 2022, jeopardizing the World Health Organization’s targets to interrupt transmission. Artificial intelligence (AI) can help address these challenges by offering the potential for rapid case detection, customized treatment, and solutions for accessibility challenges—especially in regions with a shortage of trained healthcare professionals. This perspective article explores how AI can significantly impact the clinical management of HD, focusing on therapeutic strategies. AI can help classify cases, ensure multidrug therapy compliance, monitor geographical treatment coverage, and detect adverse drug reactions and antimicrobial resistance. In addition, AI can assist in the early detection of nerve damage, which aids in disability prevention and planning rehabilitation. Incorporating AI into mental health counseling is also a promising contribution to combating the stigma associated with HD. By revolutionizing therapeutic approaches, AI offers a holistic solution to reduce the burden of HD and improve patient outcomes.

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Spatial–temporal trends in leprosy burden and its associations with socioeconomic and physical geographic factors: results from the Global Burden of Disease Study 2019

Shen,

Ding,

Wang

et al. 2024

Public Health

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Global epidemiology of leprosy from 2010 to 2020: A systematic review and meta-analysis of the proportion of sex, type, grade 2 deformity and age

Cited by 5 publications

References 47 publications

Effect of Curcuma longa Extract as Adjuvant Therapy on IL-6 Serum Levels in Leprosy Type 1 Reaction Patients

Effect of Curcuma longa Extract as Adjuvant Therapy on IL-6 Serum Levels in Leprosy Type 1 Reaction Patients

The potential role of artificial intelligence in the clinical management of Hansen’s disease (leprosy)

Spatial–temporal trends in leprosy burden and its associations with socioeconomic and physical geographic factors: results from the Global Burden of Disease Study 2019

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