Global epidemiology of epithelial ovarian cancer

Webb, Penelope M.; Jordan, Susan J.

doi:10.1038/s41571-024-00881-3

Cited by 3 publications

(2 citation statements)

References 136 publications

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“…Ovarian cancer is the eighth most common cancer in women, accounting for an estimated 3.7% of cases and 4.7% of cancer deaths in 2020. Ovarian cancer is the third most common gynecological cancer and has an incidence of approximately 308,069 cases worldwide (2020) with very high mortality rates [1]. The death rate for ovarian cancer is three times higher than for breast cancer and is projected to increase significantly by 2040 [2].…”

Section: Introductionmentioning

confidence: 99%

Activity of NAD(P)H-Oxidoreductases in Ovarian Cancer

Fedorova,

Voznesensky,

Sosnova

et al. 2024

Biomedicines

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Reactive oxygen species (ROS) play an important and controversial role in carcinogenesis. Microsomal redox chains containing NADH- and NADPH-dependent oxidoreductases are among the main sites of intracellular ROS synthesis, but their role in the oxidative balance has not been fully studied. Here, we studied the activity of cytochrome b5 reductase (CYB5R) and cytochrome P450 reductase (CYPOR) in ovarian cancer tissues and cells isolated from peritoneal fluid, along with the antioxidant capacity of peritoneal fluid. We used the developed a chemiluminescence assay based on stimulation with NADH and NADPH, which reflects the activity of CYB5R and CYPOR, respectively. The activity of CYB5R and CYPOR was significantly higher in moderately and poorly differentiated ovarian adenocarcinomas compared with well-differentiated adenocarcinomas and cystadenomas. For the chemotherapy-resistant tumors, the activity of tissue CYB5R and CYPOR was lower compared to the non-resistant tumors. In the peritoneal fluid, the antioxidant capacity significantly increased in this series, benign tumors < well-differentiated < moderately and poorly differentiated adenocarcinomas, so the antioxidant excess was observed for moderately and poorly differentiated adenocarcinomas. The antioxidant capacity of peritoneal fluid and the activity of CYB5R and CYPOR of cells isolated from peritoneal fluid were characterized by a direct moderate correlation for moderately and poorly differentiated adenocarcinomas. These results indicate the significant role of NAD(P)H oxidoreductases and the antioxidant potential of peritoneal fluid in cancer biochemistry. The parameters studied are useful for diagnostics and prognostics. The developed assay can be used to analyze CYB5R and CYPOR activity in other tissues and cells.

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Section: Introductionmentioning

confidence: 99%

Activity of NAD(P)H-Oxidoreductases in Ovarian Cancer

Fedorova,

Voznesensky,

Sosnova

et al. 2024

Biomedicines

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“…However, despite advances in medical tumor therapy, the occurrence of chemoresistance and metastatic disease are the most common causes of death in patients with ovarian cancer [20,21]. Thus, new therapeutic approaches that can improve diagnosis and treatment outcomes are needed.…”

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confidence: 99%