Global epidemiology of cutaneous zygomycosis

Skiada, Anna; Rigopoulos, Dimitrios; Larios, George; Petrikkos, George; Katsambas, Andreas

doi:10.1016/j.clindermatol.2012.01.010

Cited by 97 publications

(130 citation statements)

References 41 publications

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“…C. incongruus was also found as a nosocomial agent from a case of systemic entomophthoramycosis (Walsh et al 1994). C. lampragues has only been recovered so far from infected mammals, but it probably colonizes decaying vegetables and may also be present in soil of the areas of endemicity (de Paula et al 2010;Vilela et al 2010;Skiada et al 2012).…”

Section: Ecology and Epidemiologymentioning

confidence: 99%

Human Fungal Pathogens of Mucorales and Entomophthorales

Mendoza

Vilela

Voelz

et al. 2014

Cold Spring Harbor Perspectives in Medicine

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In recent years, we have seen an increase in the number of immunocompromised cohorts as a result of infections and/or medical conditions, which has resulted in an increased incidence of fungal infections. Although rare, the incidence of infections caused by fungi belonging to basal fungal lineages is also continuously increasing. Basal fungal lineages diverged at an early point during the evolution of the fungal lineage, in which, in a simplified four-phylum fungal kingdom, Zygomycota and Chytridiomycota belong to the basal fungi, distinguishing them from Ascomycota and Basidiomycota. Currently there are no known human infections caused by fungi in Chytridiomycota; only Zygomycotan fungi are known to infect humans. Hence, infections caused by zygomycetes have been called zygomycosis, and the term "zygomycosis" is often used as a synonym for "mucormycosis." In the four-phylum fungal kingdom system, Zygomycota is classified mainly based on morphology, including the ability to form coenocytic (aseptated) hyphae and zygospores (sexual spores). In the Zygomycota, there are 10 known orders, two of which, the Mucorales and Entomophthorales, contain species that can infect humans, and the infection has historically been known as zygomyEditors:

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Section: Ecology and Epidemiologymentioning

confidence: 99%

Human Fungal Pathogens of Mucorales and Entomophthorales

Mendoza

Vilela

Voelz

et al. 2014

Cold Spring Harbor Perspectives in Medicine

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“…In an immunecompetent host, the onset is sub-acute with vesicles or pustules that may eventually progress into eschars. On the contrary, the immune-compromised host usually presents with a rapidly progressive gangrene like form with centrally necrotic lesions surrounded by erythematous, ecchymotic or cellulitic looking skin [15]. As our patient was immune-compromised, she had similar clinical presentation.…”

Section: Discussionmentioning

confidence: 51%

“…Although cutaneous mucormycosis is associated with lower mortality rate compared to other clinical types, it has high long term morbidity if not diagnosed early and treated appropriately. Per one analysis, mortality was 4-10% for localized infection, 26-43% for cutaneous zygomycosis with deep extension, and 50-94% for disseminated disease [15].…”

Section: Discussionmentioning

confidence: 99%

Suspect the Unsuspected: An Unusual Case of Primary Cutaneous Mucormycosis at a Peripheral Intravenous Catheter Insertion Site. A Case report and Literature review

Yeruva

Kodadhala

et al. 2017

JBMOA

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Fungal Infections can have atypical presentation. This makes the diagnosis of fungal infections very challenging and in many cases increases morbidity and in unfortunate cases causes' mortality. Mucormycosis is a rare fungus which can present with wide clinical spectrum and can mislead as other etiologies. This fungus manifests itself mostly in immune compromised hosts. High index of suspicion is needed for accurate diagnosis. Prompt treatment includes combination of surgical debridement and antifungals. Early diagnosis and initiation of appropriate management can significantly decrease morbidity and mortality. Histological diagnosis is the only means of confirming mucormycosis infection. Our case is a typical example of atypical presentation of mucormycosis in an immune compromised patient which resulted in limb amputation

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“…Lesions often have a typically rapid evolution to a necrotic eschar caused by vascular invasion and infarction. 7 The arms and legs are more commonly involved, 2 and lesions have a predilection for occluded or traumatized locations, such as catheter placement sites.…”

mentioning

confidence: 99%

“…1 The spores of these fungi are ubiquitous in nature and can be acquired most commonly by direct inoculation and also from ingestion or inhalation. 2 Although zygomycosis is rare, the incidence in patients who have undergone hematopoietic stem cell transplants (HSCTs) is increasing. Data from the TransplantAssociated Infection Surveillance Network in the United States shows an increased annual incidence of zygomycosis in HSCT patients from 1.7 per 1000 patients in 2001 to 6.2 per 1000 patients in 2004.…”

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confidence: 99%