Global Cognitive Impairment in Systemic Lupus Erythematosus Patients: A Structural MRI Study

Zimmermann, Nicolle; Corrêa, Diogo Goulart; Kubo, Tadeu; Netto, Tania Maria; Pereira, Denis Batista; Fonseca, Róchele Paz; Gasparetto, Emerson L.

doi:10.1007/s00062-015-0397-8

Cited by 30 publications

(25 citation statements)

References 30 publications

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“…Hippocampal abnormalities have been well described in SLE patients and animal models. In human SLE, hippocampal atrophy, presumably reflective of neuronal loss, has been correlated with cognitive deficits (38,(44)(45)(46)(47)(48) as well as specific autoantibodies, including DNRAb (44,49). Our findings of reproducible hippocampal hypermetabolism with functional correlates extend these previous reports, suggesting an SLE-mediated attack on the hippocampus.…”

Section: Table 4 Brain Regions With Significant Differences In Fa Besupporting

confidence: 86%

Metabolic and microstructural alterations in the SLE brain correlate with cognitive impairment

Mackay¹,

Tang

et al. 2019

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Section: Table 4 Brain Regions With Significant Differences In Fa Besupporting

confidence: 86%

Metabolic and microstructural alterations in the SLE brain correlate with cognitive impairment

Mackay¹,

Tang

et al. 2019

JCI Insight

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“…MRI identifies abnormalities in up to 75% of SLE patients . However, with the exception of larger cerebral infarcts and hippocampal atrophy , the correlation between structural anatomic changes and clinical NP manifestations is poor.…”

Section: Current Status Of Npslementioning

confidence: 99%

Nervous System Disease in Systemic Lupus Erythematosus: Current Status and Future Directions

Hanly

Kozora

Beyea

et al. 2018

Arthritis & Rheumatology

120

103

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The American College of Rheumatology's case definitions for 19 neuropsychiatric syndromes in systemic lupus erythematosus (SLE) constitute a comprehensive classification of nervous system events in this disease. However, additional strategies are needed to determine whether a neuropsychiatric syndrome is attributable to SLE versus a competing comorbidity. Cognitive function is a clinical surrogate of overall brain health, with applications in both diagnosis and determination of clinical outcomes. Ischemic and inflammatory mechanisms are both key components of the immunopathogenesis of neuropsychiatric SLE (NPSLE), including abnormalities of the blood-brain barrier and autoantibody-mediated production of proinflammatory cytokines. Advances in neuroimaging provide a platform to assess novel disease mechanisms in a noninvasive way. The convergence of more rigorous clinical characterization, validation of biomarkers, and brain neuroimaging provides opportunities to determine the efficacy of novel targeted therapies in the treatment of NPSLE.

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“…Zonis et al[ 79 ] suggested that chronic intestinal inflammation alters hippocampal neurogenesis and thus might underlie the behavioural manifestations in patients with IBD. In another study, SLE patients with cognitive deficits appeared to have reduced temporal lobe structures (hippocampus and amgydala) compared to SLE patients without cognitive deficits[ 80 ]. In the present study, we did not find these correlations.…”

Section: Discussionmentioning

confidence: 99%

Cerebral magnetic resonance imaging in quiescent Crohn’s disease patients with fatigue

Erp

Ercan

Breedveld

et al. 2017

WJG

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AIMTo evaluate brain involvement in quiescent Crohn’s disease (CD) patients with fatigue using quantitative magnetic resonance imaging (MRI).METHODSMultiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue (defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTSReduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine (P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow (P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSIONThis work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls.

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Global Cognitive Impairment in Systemic Lupus Erythematosus Patients: A Structural MRI Study

Cited by 30 publications

References 30 publications

Metabolic and microstructural alterations in the SLE brain correlate with cognitive impairment

Metabolic and microstructural alterations in the SLE brain correlate with cognitive impairment

Nervous System Disease in Systemic Lupus Erythematosus: Current Status and Future Directions

Cerebral magnetic resonance imaging in quiescent Crohn’s disease patients with fatigue

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