Global Cerebral Glucose Utilization Is Independent of Brain Size

Hatazawa, Jun; Ra, Brooks; G, Di Chiro; Campbell, Gerald A.

doi:10.1097/00004728-198707000-00002

Cited by 28 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with the findings of sex differences in cerebral blood flow, cerebral metabolic rate of glucose utilization (CMRglu) tends to be higher in women versus men (46), particularly in the orbital frontal area (47) although not consistently (48)(49)(50). However, global CMRglu may be inversely correlated with brain size such that individuals with smaller brains have higher CMRglu (48;51), effectively negating sex differences in metabolism.…”

Section: Sex Differences In Brain Functionmentioning

confidence: 74%

Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry

Cosgrove

Mazure

Staley

2007

Biological Psychiatry

878

615

View full text Add to dashboard Cite

Background-Clinical and epidemiologic evidence demonstrates sex differences in the prevalence and course of various psychiatric disorders. Understanding sex-specific brain differences in healthy individuals is a critical first step towards understanding sex-specific expression of psychiatric disorders. Here, we evaluate evidence on sex differences in brain structure, chemistry and function using imaging methodologies, including functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT) and structural magnetic resonance imaging (MRI) in mentally healthy individuals.

show abstract

Section: Sex Differences In Brain Functionmentioning

confidence: 74%

Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry

Cosgrove

Mazure

Staley

2007

Biological Psychiatry

878

615

View full text Add to dashboard Cite

show abstract

“…An additional ROI comprised the whole brain slice on the OM-slice corresponding to Talairach's slice 7-8. Its size can be taken as a relative estimate of the size of the whole brain (22). The difference of group means was tested using Student's t-test after testing for equality of variances (F-test).…”

Section: Analysis Of Pet Datamentioning

confidence: 99%

Frontal lobe function in amyotrophic lateral sclerosis: a neuropsychologic and positron emission tomography study

Ludolph¹,

Langen²,

Regard³

et al. 1992

Acta Neurologica Scandinavica

292

154

View full text Add to dashboard Cite

In this study the regional cerebral glucose utilization and the neuropsychological performance of patients with amyotrophic lateral sclerosis (ALS) was investigated. Special attention was given to neuropsychological tests thought to mirror frontal lobe dysfunction. The regional cerebral glucose utilization was studied in 18 patients using high-resolution positron emission tomography. Clinically all patients displayed upper and lower motor neurone signs. In ALS patients glucose metabolism was significantly reduced in the frontal and in the entire cortex compared with controls; no changes were seen in the cerebellum. Comprehensive neuropsychological assessment of ALS patients compared to a pair matched control group revealed mild frontal dysfunction which in part significantly correlated with reduced glucose metabolism in the cortex and subcortical structures. We conclude that in patients with ALS, glucose consumption is decreased in parts of the brain other than the motor cortex accompanied by mild neuropsychological deficits based on the tests employed in this study.

show abstract

“…However, we did not observe sex differences in wave I amplitude or latency, which reflect the peripheral processing of auditory stimuli. Yet other bases for sex differences are suggested by reports that females have more neurons per unit volume in the auditory association cortex of the planum temporale [23] and a higher cerebral glucose metabolic rate than males [24]. Our study had no measures relevant to these intriguing possibilities.…”

Section: Discussionmentioning

confidence: 86%

Sex and gestational age effects on auditory brainstem responses in preterm and term infants

Zhu

Mai

et al. 2013

Early Human Development

View full text Add to dashboard Cite

Background Some studies find delayed development of the auditory brainstem in preterm infants, but others do not. Aim To compare auditory brainstem responses (ABRs) in healthy preterm and term infants depending on sex and gestational age (GA). Methods Participants were 111 preterm (27–36 weeks GA) and 92 term (37–41 weeks GA) infants. ABR tests were conducted at 6 weeks (corrected age if preterm). Results There were no overall differences between term and preterm groups in ABRs. However, males showed longer latencies for waves III, V, and I–III, III–V, and I–V intervals and smaller amplitudes for wave III and V than females in both preterm and term groups (all p values ≤ .01). A 3-way interaction between group, sex, and GA (p < .05) showed that preterm males with later GA had longer wave I–V interval, whereas term females with later GA showed shorter wave I–V interval. Growth velocity predicted wave I–V interval in preterm infants, controlling for other factors (male: p = .07, female: p < .05). Conclusion ABRs in preterm and term infants were similar at 6 weeks (corrected age if preterm), but males had less advanced ABRs than females. More rapid growth predicted less mature ABR in later GA preterm infants in this setting where they were unlikely to receive extra iron. The roles of GA, growth, and iron balance in ABR development warrant further study.

show abstract

Global Cerebral Glucose Utilization Is Independent of Brain Size

Cited by 28 publications

References 0 publications

Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry

Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry

Frontal lobe function in amyotrophic lateral sclerosis: a neuropsychologic and positron emission tomography study

Sex and gestational age effects on auditory brainstem responses in preterm and term infants

Contact Info

Product

Resources

About