Global burden of sepsis: a systematic review

Fleischmann, Carolin; Scherag, André; Adhikari, NK; Hartog, CS; Τσαγανός, Θωμάς; Angus, DC; Reinhart, Konrad

doi:10.1186/cc14101

Cited by 48 publications

(46 citation statements)

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“…A meta-analysis of 27 studies from seven high-income countries found a yearly incidence of 437 and 270 per 100.000 for sepsis and severe sepsis, respectively. Extrapolation of these data would estimate 5.3 million deaths yearly worldwide (15).…”

Section: Epidemiology Of An Over-and Under -Diagnosed Conditionmentioning

confidence: 99%

Lactate kinetics and mitochondrial respiration in skeletal muscle of healthy humans under influence of adrenaline

et al. 2015

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Plasma lactate is widely used as a biomarker in critical illness. The aims of the present study were to elucidate the usefulness of a three-compartment model for muscle lactate kinetics in humans and to characterize the response to an exogenous adrenaline challenge. Repeated blood samples from artery and femoral vein together with blood flow measurements and muscle biopsies were obtained from healthy male volunteers (n=8) at baseline and during an adrenaline infusion. Concentrations of lactate and enrichment of [13C]lactate were measured and kinetics calculated. Mitochondrial activity, glycogen concentration, oxygen uptake and CO2 release were assessed. The adrenaline challenge increased plasma lactate 4-fold as a result of a greater increase in the rate of appearance (R(a)) than the increase in the rate of disappearance (R(d)). Leg muscle net release of lactate increased 3.5-fold, whereas intramuscular production had a high variation but did not change. Mitochondrial state 3 respiration increased by 30%. Glycogen concentration, oxygen uptake and CO2 production remained unchanged. In conclusion a three-compartment model gives additional information to the two-compartment model but, due to its larger variation and invasive muscle biopsy, it is less likely to become a regularly used tool in clinical research. Hyperlactataemia in response to adrenergic stimuli was driven by an elevated lactate release from skeletal muscle most probably due to a redirection of a high intramuscular turnover rather than an increased production.

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Section: Epidemiology Of An Over-and Under -Diagnosed Conditionmentioning

confidence: 99%

Lactate kinetics and mitochondrial respiration in skeletal muscle of healthy humans under influence of adrenaline

et al. 2015

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“…It is hypothesized that in such cases microbiome mutiny may aggravate the already weakened condition of the hosts, potentially contributing to their death (Rózsa et al, 2015). In this paper we argue that some cases of sepsis, a condition that causes approximately 6 million human fatalities per year globally (Fleischmann et al, 2015), might be interpreted as a particular manifestation of this phenomenon. Specifically, we aim to show that sepsis, although it is usually a noncontagious condition, does enhance the transmission of the causative microbes to new hosts in a rather surprising way.…”

Section: Introductionmentioning

confidence: 86%

The evolutionary logic of sepsis

Rózsa

Apari

Sulyok

et al. 2017

Infection, Genetics and Evolution

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“…The first crude estimate of worldwide incidence of sepsis was 15-19 million (Adhikari et al, 2010). To provide a more refined estimate for the Lancet Infectious Diseases Commission, Fleischmann et al (2015) identified 33 studies providing population-level data incidence of hospital-treated sepsis. Based on these studies, Fleischmann et al (2015) estimated the annual incidence was up to 31 million cases of sepsis (similar to the SSC estimate of 30 million people worldwide each year (World Sepsis Day, 2015)) and 24 million cases of severe sepsis, with about 6 million death rates.…”

Section: Global Impactmentioning

confidence: 99%

Overview of the incidence, early identification and management of sepsis

Ward¹,

Morrell-Scott

2018

Nursing Standard

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Sepsis is a potentially life-threatening condition that is triggered by an infection. Sepsis is an urgent public health issue globally, and is one of the leading causes of death in emergency departments and hospitals. However, consensus definitions of sepsis are imprecise and the incidence and costs of the condition are thought to be underestimated. This article discusses the incidence of sepsis globally and nationally, and the effects of the condition. It emphasises the early identification and effective management of sepsis, which remain crucial to improving patient outcomes such as morbidity and mortality. It also outlines the nurse's role in providing sepsis care.

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Global burden of sepsis: a systematic review

Cited by 48 publications

References 0 publications

Lactate kinetics and mitochondrial respiration in skeletal muscle of healthy humans under influence of adrenaline

Lactate kinetics and mitochondrial respiration in skeletal muscle of healthy humans under influence of adrenaline

The evolutionary logic of sepsis

Overview of the incidence, early identification and management of sepsis

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