Global Burden of Mental, Neurological, and Substance Use Disorders: An Analysis from the Global Burden of Disease Study 2010

Whiteford, Harvey; Ferrari, Alize J.; Degenhardt, Louisa; Feigin, Valery; Vos, Theo

doi:10.1596/978-1-4648-0426-7_ch2

Cited by 259 publications

(291 citation statements)

References 39 publications

(42 reference statements)

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“…Mental, neurological, and substance use disorders have consistently been shown to contribute, substantially, to the global burden of disease and account for a significant proportion of years lived with disability and years lost to premature mortality . Despite the burgeoning worldwide prevalence of mental health concerns, as well as the demonstrated efficacy of psychological interventions, treatment utilization rates for psychological interventions remains low .…”

Section: Introductionmentioning

confidence: 99%

Public stigma and attitudes toward psychological help-seeking in the United Arab Emirates: The mediational role of self-stigma

Vally

Cody

Albloshi

et al. 2018

Perspect Psychiatr Care

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Section: Introductionmentioning

confidence: 99%

Public stigma and attitudes toward psychological help-seeking in the United Arab Emirates: The mediational role of self-stigma

Vally

Cody

Albloshi

et al. 2018

Perspect Psychiatr Care

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“…Illicit substance use is a major health issue associated with serious physical, psychological and social harm . Approximately 187 000 of 27 million illicit substance users die annually due to drug‐related deaths .…”

Section: Introductionmentioning

confidence: 99%

Internet interventions for adult illicit substance users: a meta-analysis

et al. 2017

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Background and AimsResearch has shown that internet interventions can be effective for dependent users of various substances. However, less is known about the effects of these interventions on users of opioids, cocaine and amphetamines than for other substances. We aimed to investigate the effectiveness of internet interventions in decreasing the usage of these types of substances.MethodsWe conducted a systematic literature search in the databases of PubMed, PsycINFO, Embase and the Cochrane Library to identify randomized controlled trials examining the effectiveness of internet interventions compared with control conditions in reducing the use of opioids, cocaine and amphetamines. No setting restrictions were applied. The risk of bias of the included studies was examined according to the Cochrane Risk of Bias assessment tool. The primary outcome was substance use reduction assessed through toxicology screening, self‐report or both at post‐treatment and at the follow‐up assessment.ResultsSeventeen studies with 2836 adult illicit substance users were included. The risk of bias varied across the included studies. Internet interventions decreased significantly opioid [four studies, n = 606, g = 0.36; 95% confidence interval (CI) = 0.20–0.53, P < 0.001] and any illicit substance use (nine studies, n = 1749, g = 0.35; 95% CI = 0.24–0.45, P < 0.001) at post‐treatment. Conversely, the effect of internet intervention for stimulant users was small and non‐significant (four studies, n = 481, P = 0.164). Overall, internet interventions decreased substance significantly use at post‐treatment (17 studies, n = 2836, g = 0.31; 95% CI = 0.23–0.39, P < 0.001) and at the follow‐up assessments (nine studies, n = 1906, g = 0.22; 95% CI = 0.07–0.37; P = 0.003).ConclusionsInternet interventions demonstrate small but significant effects in decreasing substance use among various target populations at post‐treatment and at the follow‐up assessment. However, given the small number of available studies for certain substances, the findings should be interpreted with caution.

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“…In 2010 alone, PD accounted for 1,900,000 disability-adjusted life years (DALY), amounting to 0.1% of the DALYs from all causes, and 0.7% of mental, neurological and substance abuse DALYs [150].…”

Section: Resultsmentioning

confidence: 99%

Rational drug discovery design approaches for treating Parkinson’s disease

Schyf

2015

Expert Opinion on Drug Discovery

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Largely due to the intertwined etiology that is a hallmark of PD's pathology, neuroprotective drug discovery is challenging, while very limited targeting strategies exist for the non-motor symptoms that afflict sufferers of PD. Rational approaches toward PD neurotherapeutics should target previously identified or emerging pathological pathways that are discovered in the course of investigating the underlying mechanisms in PD disease progression. Each of these pathways contributes to events that ultimately lead to the complex disease burden seen in PD and can form the basis for rational and highly targeted drug development.

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Global Burden of Mental, Neurological, and Substance Use Disorders: An Analysis from the Global Burden of Disease Study 2010

Abstract: Background

Cited by 259 publications

References 39 publications

Public stigma and attitudes toward psychological help-seeking in the United Arab Emirates: The mediational role of self-stigma

Public stigma and attitudes toward psychological help-seeking in the United Arab Emirates: The mediational role of self-stigma

Internet interventions for adult illicit substance users: a meta-analysis

Rational drug discovery design approaches for treating Parkinson’s disease

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