Global burden of cirrhosis and liver cancer due to alcohol: the past, present, and the future

Xie, Chencheng; Singal, Ashwani K.

doi:10.1007/s12072-023-10534-9

Cited by 3 publications

(1 citation statement)

References 13 publications

(21 reference statements)

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“…In terms of SDI, this study found that the prevalence of ALD and AUD was highest in high SDI countries, which aligned with previous studies in overall populations. 26 , 27 High SDI countries underwent a decline in mortality and disability of AUD and ALD, whereas low and low-middle SDI countries underwent an increase in these parameters of AUD and ALD, possibly reflecting alcohol industry strategies targeting these segments herein, by passing stricter regulation and public health campaigns in high SDI countries. 28 This discrepancy can be attributed to factors such as higher access to healthcare, increased health literacy, and fewer adjunctive risk factors for ALD and AUD.…”

Section: Discussionmentioning

confidence: 99%

Global and regional burden of alcohol-associated liver disease and alcohol use disorder in the elderly

Danpanichkul,

Suparan,

et al. 2024

JHEP Reports

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Section: Discussionmentioning

confidence: 99%

Global and regional burden of alcohol-associated liver disease and alcohol use disorder in the elderly

Danpanichkul,

Suparan,

et al. 2024

JHEP Reports

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Research Priorities and Future Landscape of Clinical Trials in Alcohol-Associated Liver Disease

Kulkarni,

Singal,

Kamath

2024

Clinics in Liver Disease

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Fecal microbiota transplantation in severe alcohol-associated hepatitis: mortality effect and 3 PM-guided analysis of associated factors.

Skladany,

Kubanek,

Selcanova

et al. 2024

Preprint

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Background: Severe alcohol-associated hepatitis (SAH) is the most serious phenotype of the alcohol-associated liver disease (ALD) spectrum, characterized by high short-term mortality. The only approved therapy with corticosteroids (CS) has modest and short-term survival benefits; moreover, new therapeutic alternatives are unmet need. Fecal microbiota transplantation (FMT) has gained attention as a potential therapeutic option for filling this gap. In this study, we aimed to determine the effect of FMT on mortality in patients with SAH beyond CS and search for factors predictive of outcome, which could be leveraged in a real-life predictive, preventive, and personalized medicine (3 PM) management of SAH. Methods: We conducted a prospective study (NCT04758806) in adult patients with SAH, non-responders (NR) to CS, or non-eligible (NE) for CS between January 2018 and August 2022. FMT intervention consisted of five 100 ml doses (prepared beforehand from 30g stool from an unrelated healthy donor and frozen at − 80°C) administered daily to the upper gastrointestinal (GI) tract. We evaluated the impact of FMT on short-term mortality as determined by the propensity score matching with the historical cohort derived from our RH7 registry (NCT04767945). Also, we scrutinized SAH-related prognostic factors and scores such as Model for end-stage liver disease (MELD), Maddrey Discriminant Function (MDF), Acute-on-chronic liver failure (ACLF), Liver Frailty Index (LFI), Hepatic venous-portal gradient (HVPG) and AAHS (Alcoholic Hepatitis Histologic Score), for more precise prediction of response to therapy and their future potential in predictive, preventive, and personalized patient management. Results: We enrolled 44 patients with SAH (NR + NE to CS) who were intended to be treated with FMT and analyzed 33 patients per protocol (after an additional 11 being excluded for receiving less than 5 doses of FMT). The mean age was 49.6y, 11 patients (33.3%) were females. The median MELD-Na score was 29, and ACLF of any degree had 27 patients (81.8%). FMT improved 30-day survival over the historical control group (p = 0.0204); ninety-day survival was improved but did not reach statistical significance (p = 0.4386). As predictors of FMT failure - evaluated by the surrogate of short-term mortality -, we identified baseline MELD ≥30, MDR ≥ 90, and ACLF grade > 1, respectively (p=0.016; p=0.024; p=0.01). Survival was not associated with baseline liver frailty index (LFI), hepatic venous-portal gradient (HVPG), or Alcoholic Hepatitis Histological Score (AHHS). Conclusion: Severe alcohol-associated hepatitis in patients beyond CS was confirmed to be associated with high short-term mortality. In this difficult-to-treat cohort, FMT improved 30-day survival over historical controls chosen by propensity score matching. Factors associated with better outcomes were MELD-Na ≤ 30, MDR ≤ 90, and ACLF < 2. Therefore, our results lend support to the notion that FMT can be considered a 3 PM approach: albeit more data is needed, FMT and the described factors are good candidates for the unmet need of preventing death, predicting therapeutic response, and personalized management of SAH.

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Global burden of cirrhosis and liver cancer due to alcohol: the past, present, and the future

Cited by 3 publications

References 13 publications

Global and regional burden of alcohol-associated liver disease and alcohol use disorder in the elderly

Global and regional burden of alcohol-associated liver disease and alcohol use disorder in the elderly

Research Priorities and Future Landscape of Clinical Trials in Alcohol-Associated Liver Disease

Fecal microbiota transplantation in severe alcohol-associated hepatitis: mortality effect and 3 PM-guided analysis of associated factors.

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