Global burden and trends of the Entamoeba infection-associated diseases from 1990 to 2019: An observational trend study

Fu, Xiaofang; Zhong, Yueyang; Chen, Liyan; Ge, Minjie; Yu, Min; Sun, Yichuang; Shen, Linfeng

doi:10.1016/j.actatropica.2023.106866

Cited by 5 publications

(11 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…dispar seems to be more prevalent than E . histolytica with 12% prevalence worldwide [ 69 ], likewise in this study, we found E . dispar rather than E .…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Molecular diagnosis of intestinal protozoa in young adults and their pets in Colombia, South America

Potes-Morales

Crespo-Ortiz

2023

PLoS ONE

View full text Add to dashboard Cite

Intestinal parasitic infections have been considered a relevant public health problem due to the increased incidence worldwide. In developing countries, diarrhea and gastrointestinal symptoms cause impaired work capacity in adults and delayed rate growth in children. Enteric infections of unknown etiology can often lead to misdiagnosis, increased transmission, and morbidity. The aim of this study was to determine the prevalence of intestinal parasites in a young adult population and their pets. Stool samples from 139 university students and 44 companion animals were subjected to microscopy diagnosis using wet mounts, concentration by zinc sulphate flotation and staining techniques (Kinyoun and trichrome stain). Molecular diagnosis of protozoa was also performed by conventional PCR. The mean age was 24 years, 54% individuals were female, 46% were men, and 66% had at least one pet. The overall prevalence for at least one parasite was 74.8% and the rate of polyparasitism was 37.5%. Eighty-three patients (59.7%) were positive for Blastocystis spp., followed by Cryptosporidium spp. 24.5%, Endolimax nana 13.6%, Entamoeba dispar/E. moshkovskii 7.8% and Giardia intestinalis 1.4%. Molecular diagnosis substantially improved Cryptosporidium spp. and Blastocystis spp. detection and allowed to distinguish E. histolytica from commensals in the Entamoeba complex. Student’s pets were also examined for parasitism. Samples from 27 dogs, 15 cats, one rabbit and one hen were analyzed, and parasites were detected in 30 (68.2%) as follows: Cryptosporidium spp. (24) Giardia spp. (4), hookworm (3), Endolimax nana (2) and Toxoplasma gondii (1). Overall, university students showed high prevalence of parasitism and polyparasitism suggesting exposure to parasite infected animals and contaminated environments. Cryptosporidium spp. was the predominant pathogen in human and domestic animals, and it was only detected by PCR, pointing out the need for sensitive tests in diagnosis and surveillance. Control strategies to prevent the effects of parasitic infections in young population should consider pets as reservoirs and transmission source.

show abstract

“…dispar seems to be more prevalent than E . histolytica with 12% prevalence worldwide [ 69 ], likewise in this study, we found E . dispar rather than E .…”

Section: Discussionsupporting

confidence: 87%

“…histolytica and reporting very little or no detection of the pathogen (0%- 0.39%) [ 37 , 57 , 58 , 68 ]. Worldwide trends reveal a decline in Entamoeba infections although a high burden is still seen in some age groups and low-income regions [ 69 ]. Prevalence of E .…”

Section: Discussionmentioning

confidence: 99%

Molecular diagnosis of intestinal protozoa in young adults and their pets in Colombia, South America

Potes-Morales

Crespo-Ortiz

2023

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Long term trends of ASMRs were categorized into distinct segments and assessed the significance of the trends within every segment ( 25 , 26 ). That is, the method could identify inflection points in the trend data and use them to divide the overall trend into smaller sub-segments, which evaluate the magnitude of the epidemiological trend ( 27 ). In the study, we could conduct an estimation of how the TB mortality attributable HFPG changes over time, and enable the identification of particular phases of growth or decline, provide valuable information on how the disease develops.…”

Section: Methodsmentioning

confidence: 99%

“…The age-period-cohort analysis was conducted using the age-period-cohort web tool provided by the Biostatistics Branch, National Cancer Institute in Bethesda, MD. The tool can be accessed at https://analysistools.nci.nih.gov/apc/ ( 26 , 27 ). Our statistical analyses were two-sided, and values with p < 0.05 were deemed statistically significant.…”

Section: Methodsmentioning

confidence: 99%

Temporal trends in mortality of tuberculosis attributable to high fasting plasma glucose in China from 1990 to 2019: a joinpoint regression and age-period-cohort analysis

Wang¹,

Yang²,

Zhang³

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

BackgroundNowadays, high fasting plasma glucose (HFPG) has been identified as the important risk factor contributing to the increased burden of diseases. But there remains a lack of research on tuberculosis (TB) mortality specifically attributable to HFPG. Thus, this study aims to explore the long-term trends in HFPG-related TB mortality in China from 1990 to 2019.MethodsData on HFPG-related TB mortality were obtained from the Global Burden of Disease (GBD) Study 2019. Analyzing the data using joinpoint regression and age-period-cohort methods adjusting for age, period, and cohort allowed us to assess the trends in TB mortality due to HFPG.ResultsThe age-standardized mortality rates (ASMRs) of TB attributable to HFPG exhibited a downward trend in China from 1990 to 2019, with an average annual percentage change (AAPC) of −7.0 (95% CI, −7.5 to −6.6). Similar trends were found for male (AAPC of −6.5 [95% CI, −7.0 to −6.0]) and female (AAPC of −8.2 [95% CI, −8.5 to −7.9]), respectively. Local drifts curve with a U-shaped pattern reflected the AAPC of TB mortality due to HFPG across age groups. The greatest decline was observed in the age group of 60–64 years. The mortality rates related to HFPG first increased and then decreased with increasing age, peaking in the 55–59 age group. Our analysis of the period and cohort effects found that the rate ratios of TB mortality due to HFPG have decreased over the past three decades, more prominently in women. It is noteworthy that while both genders have seen a decline in HFPG-attributable TB mortality and risk, men have a higher risk and slightly less significant decline than women.ConclusionThe present study shows that HFPG–related ASMRs and risk of TB in China decreased over the last 30 years, with similar trends observed in both men and women. In order to attain the recommended level set by the WHO, the effective strategies for glycemic control and management still needed to be implemented strictly to further decrease the burden of TB.

show abstract

“…According to The Global Burden of Diseases Study of 2016, it is estimated that over 123 million new cases of infection with E. histolytica are reported worldwide [212]. Amoebiasis is responsible for more than 26,000 deaths annually and 2.5 million disability-adjusted life year (DALY) cases [213]. E. histolytica infections remain a heavy burden among children younger than 5 years, particularly in areas with a low sociodemographic index [213].…”

Section: Amoebiasismentioning

confidence: 99%

Neutrophils versus Protozoan Parasites: Plasmodium, Trichomonas, Leishmania, Trypanosoma, and Entameoba

Uribe-Querol,

Rosales

2024

Microorganisms

View full text Add to dashboard Cite

Neutrophils are the most abundant polymorphonuclear granular leukocytes in human blood and are an essential part of the innate immune system. Neutrophils are efficient cells that eliminate pathogenic bacteria and fungi, but their role in dealing with protozoan parasitic infections remains controversial. At sites of protozoan parasite infections, a large number of infiltrating neutrophils is observed, suggesting that neutrophils are important cells for controlling the infection. Yet, in most cases, there is also a strong inflammatory response that can provoke tissue damage. Diseases like malaria, trichomoniasis, leishmaniasis, Chagas disease, and amoebiasis affect millions of people globally. In this review, we summarize these protozoan diseases and describe the novel view on how neutrophils are involved in protection from these parasites. Also, we present recent evidence that neutrophils play a double role in these infections participating both in control of the parasite and in the pathogenesis of the disease.

show abstract

Global burden and trends of the Entamoeba infection-associated diseases from 1990 to 2019: An observational trend study

Cited by 5 publications

References 40 publications

Molecular diagnosis of intestinal protozoa in young adults and their pets in Colombia, South America

Molecular diagnosis of intestinal protozoa in young adults and their pets in Colombia, South America

Temporal trends in mortality of tuberculosis attributable to high fasting plasma glucose in China from 1990 to 2019: a joinpoint regression and age-period-cohort analysis

Neutrophils versus Protozoan Parasites: Plasmodium, Trichomonas, Leishmania, Trypanosoma, and Entameoba

Contact Info

Product

Resources

About