Our goal in this paper is to investigate the global asymptotic stability of the hyperbolic equilibrium solution of the second order rational difference equationxn+1=α+βxn+γxn-1/A+Bxn+Cxn-1,n=0,1,2,…, where the parametersA≥0andB,C,α,β,γare positive real numbers and the initial conditionsx-1, x0are nonnegative real numbers such thatA+Bx0+Cx-1>0. In particular, we solve Conjecture 5.201.1 proposed by Camouzis and Ladas in their book (2008) which appeared previously in Conjecture 11.4.2 in Kulenović and Ladas monograph (2002).