Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study

Takeuchi, Hikaru; Taki, Yasuyuki; Nouchi, Rui; Yokoyama, Ryoichi; Kotozaki, Yuka; Nakagawa, Seishu; Sekiguchi, Atsushi; Iizuka, Kunio; Yamamoto, Yuki; Hanawa, Sugiko; Araki, Tsuyoshi; Miyauchi, Carlos Makoto; Shinada, Takamitsu; Sakaki, Kohei; Sassa, Yuko; Nozawa, Takayuki; Ikeda, Shigeyuki; Yokota, Susumu; Magistro, Daniele; Kawashima, Ryuta

doi:10.1038/s41598-017-10104-8

Cited by 43 publications

(35 citation statements)

References 69 publications

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“…The present study has two important limitations. First, as emphasized in our previous work (Takeuchi et al, ), our population was restricted to young healthy subjects (18–27 years) with higher levels of education. Further investigation is needed to confirm whether our findings hold true across different age groups and education levels.…”

Section: Discussionmentioning

confidence: 99%

“…We employed the same preprocessing procedures as described previously (Takeuchi et al, ). The preprocessing was performed using Statistical Parametric Mapping software (SPM12; Wellcome Department of Cognitive Neurology, London, UK, https://www.fil.ion.ucl.ac.uk/spm/) implemented in Matlab (Mathworks Inc., Natick, MA).…”

Section: Methodsmentioning

confidence: 99%

“…Only voxels with values exceeding an absolute threshold of 0.05 were targeted for the analysis. This threshold is widely used in VBM studies (Beal, Gracco, Lafaille, & Nil, 2007;Focke, Thompson, & Duncan, 2008;Mueller et al, 2006;Nauchi & Sakai, 2009;Schaufelberger et al, 2007;Takeuchi et al, 2010Takeuchi et al, , 2011Takeuchi et al, , 2017bWhite, Alkire, & Haier, 2003). To test whether the associations between rGMV and the Preoccupation Scale subscores were statistically significant, a permutation-based voxel-wise nonparametric test (5,000 permutations) was performed using the threshold-free cluster enhancement (TFCE) toolbox (http://dbm.neuro.uni-jena.de/tfce/; r95) (Smith & Nichols, 2009).…”

Section: Second-level Analysismentioning

confidence: 99%

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Neural substrates of self‐ and external‐preoccupation: A voxel‐based morphometry study

et al. 2019

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Introduction Self‐ and external‐preoccupation have been linked to psychopathological states. The neural substrates underlying self‐ and external‐preoccupation remain unclear. In the present study, we aim to provide insight into the information‐processing mechanisms associated with self‐ and external‐preoccupation at the structural level. Methods To investigate the neural substrates of self‐ and external‐preoccupation, we acquired high‐resolution T1‐weighted structural images and Preoccupation Scale scores from 1,122 young subjects. Associations between regional gray matter volume (rGMV) and Preoccupation Scale subscores for self‐ and external‐preoccupation were estimated using voxel‐based morphometry. Results Significant positive associations between self‐preoccupation and rGMV were observed in widespread brain areas such as the bilateral precuneus and posterior cingulate gyri, structures known to be associated with self‐triggered self‐reference during rest. Significant negative associations between external‐preoccupation and rGMV were observed only in the bilateral cerebellum, regions known to be associated with behavioral addiction, sustained attention, and reward system. Conclusion Our results reveal distinct neural substrates for self‐ and external‐preoccupation at the structural level.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Second-level Analysismentioning

confidence: 99%

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Neural substrates of self‐ and external‐preoccupation: A voxel‐based morphometry study

et al. 2019

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“…Relatively weak correlations (r < 0.2) between individual cognitive differences and neuroimaging measures are actually common in studies using huge samples of young normal adults (i.e., N > several hundred) regardless of the specific imaging measures (Magistro et al 2015;Schilling et al 2012;Takeuchi et al 2015cTakeuchi et al , 2017. In fact, we are not aware of any exceptions.…”

Section: Discussionmentioning

confidence: 88%

General intelligence is associated with working memory-related brain activity: new evidence from a large sample study

et al. 2018

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Psychometric intelligence is closely related to working memory capacity. Here we aim to determine the associations of neural activation patterns during the N-back working memory paradigm with psychometric intelligence and working memory performance. We solved the statistical problems of previous studies using (1) a large cohort of 1235 young adults and (2) robust voxel-by-voxel permutation-based statistics at the whole-brain level. Many of the significant correlations were weak, and our findings were not consistent with those of previous studies. We observed that many of the significant correlations involved brain areas in the periphery or boundaries between the task-positive network (TPN) and task-negative network (TNN), suggesting that the expansion of the TPN or TNN is associated with greater cognitive ability. Lower activity in TPN and less task-induced deactivation (TID) in TNN were associated with greater cognitive ability. These findings indicate that subjects with greater cognitive ability have a lower brain response to task demand, consistent with the notion that TID in TNN reflects cognitive demand but partly inconsistent with the prevailing neural efficiency theory. One exception was the pre-supplementary motor area, which plays a key role in cognitive control and sequential processing. In this area, intelligent subjects demonstrated greater activity related to working memory, suggesting that the pre-supplementary motor area plays a unique role in the execution of working memory tasks in intelligent subjects.

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“…A study of voxel-wise analyses for correlations between the spatial cognitive function and rGMV was published elsewhere 28 .…”

Section: Methodsmentioning

confidence: 99%

Allergic tendencies are associated with larger gray matter volumes

Takeuchi

Taki

Nouchi

et al. 2018

Sci Rep

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Allergic tendencies are associated with important cognitive and physiological factors, such as intelligence and mathematical abilities. Allergies are widely prevalent, especially in modern life, and the reason for its association with important cognitive variables is an intriguing scientific question. However, despite the unique characteristics of cognitive correlates of allergy, the anatomical correlates of allergy remain unknown. The aim of this study was to identify the associations between regional gray matter volume (rGMV) and allergic tendencies in young adults. In a study cohort of 1,219 healthy, educated young adults, we identified a positive correlation between total allergic tendency and rGMV in large anatomical clusters that mainly encompassed the dorsal part of the cerebral neocortex, right anterior insula, and cerebellum. Furthermore,both mean rGMV of the entire part of these clusters and total allergenic tendency showed a significant positive correlation with spatial ability. These results suggest the link among allergic tendencies, larger rGMV, and the better spatial ability in healthy, educated young adults.

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Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study

Cited by 43 publications

References 69 publications

Neural substrates of self‐ and external‐preoccupation: A voxel‐based morphometry study

Neural substrates of self‐ and external‐preoccupation: A voxel‐based morphometry study

General intelligence is associated with working memory-related brain activity: new evidence from a large sample study

Allergic tendencies are associated with larger gray matter volumes

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