Global and Regional Myocardial Function Quantification by Two-Dimensional Strain

Serri, Karim; Réant, Patricia; Lafitte, Marianne; Berhouet, Marianne; Bouffos, V. Le; Roudaut, R.; Lafitte, Stéphane

doi:10.1016/j.jacc.2005.10.061

Cited by 462 publications

(399 citation statements)

References 16 publications

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“…Recent advances in the ability to measure LV strain have afforded the opportunity to characterize myocardial contractility in a wide range of experimental and clinical settings (6,10,11,25,35,37,44). Normal values and measurement variability data for this imaging modality have recently been published (18,42). Several recent studies have characterized resting LV strain and the impact of a single exercise session on LV strain in trained athletes (32)(33)(34).…”

Section: Discussionmentioning

confidence: 99%

The impact of endurance exercise training on left ventricular systolic mechanics

Baggish¹,

Yared²,

Wang³

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

117

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Although exercise training-induced changes in left ventricular (LV) structure are well characterized, adaptive functional changes are incompletely understood. Detailed echocardiographic assessment of LV systolic function was performed on 20 competitive rowers (10 males and 10 females) before and after endurance exercise training (EET; 90 days, 10.7 Ϯ 1.1 h/wk). Structural changes included LV dilation (end-diastolic volume ϭ 128 Ϯ 25 vs. 144 Ϯ 28 ml, P Ͻ 0.001), right ventricular (RV) dilation (end-diastolic area ϭ 2,850 Ϯ 550 vs. 3,260 Ϯ 530 mm 2 , P Ͻ 0.001), and LV hypertrophy (mass ϭ 227 Ϯ 51 vs. 256 Ϯ 56 g, P Ͻ 0.001). Although LV ejection fraction was unchanged (62 Ϯ 3% vs. 60 Ϯ 3%, P ϭ not significant), all direct measures of LV systolic function were altered. Peak systolic tissue velocities increased significantly (basal lateral SЈ⌬ ϭ 0.9 Ϯ 0.6 cm/s, P ϭ 0.004; and basal septal SЈ⌬ ϭ 0.8 Ϯ 0.4 cm/s, P ϭ 0.008). Radial strain increased similarly in all segments, whereas longitudinal strain increased with a base-to-apex gradient. In contrast, circumferential strain (CS) increased in the LV free wall but decreased in regions adjacent to the RV. Reductions in septal CS correlated strongly with changes in RV structure (⌬RV end-diastolic area vs. ⌬LV septal CS; r 2 ϭ 0.898, P Ͻ 0.001) and function (⌬peak RV systolic velocity vs. ⌬LV septal CS, r 2 ϭ 0.697, P Ͻ 0.001). EET leads to significant changes in LV systolic function with regional heterogeneity that may be secondary to concomitant RV adaptation. These changes are not detected by conventional measurements such as ejection fraction.athlete's heart; left ventricle; strain; ventricular interdependence LEFT VENTRICULAR (LV) structural adaptation in response to aerobic endurance exercise training (EET) has been well characterized. Increases in LV chamber dimensions, wall thickness, and mass have been documented among individuals who participate in EET, and it is these structural attributes that underlie the concept of the "athlete's heart" (8,38,41). At the present time, the impact of EET on LV functional mechanics is less clear.Several reports demonstrate that EET results in enhanced LV diastolic function (3,23,31). In contrast, existing data suggest that LV systolic function is unchanged by EET (9,15,39). Previous studies examining the impact of EET on LV systolic function have relied on indexes such as ejection fraction or fractional area change that may lack the sensitivity to detect regional changes in myocardial function. Novel imaging techniques such as two-dimensional strain and tissueDoppler echocardiography are direct, more sensitive methods of assessing myocardial systolic function (13,14). To date, a prospective and longitudinal assessment of the impact of EET on LV systolic function using these techniques has not been conducted.We hypothesized that EET would result in enhanced resting LV contractility but that this adaptation would be underrepresented by conventional indexes of systolic function. To address this hypothesis, we performed a focused ...

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Section: Discussionmentioning

confidence: 99%

The impact of endurance exercise training on left ventricular systolic mechanics

Baggish¹,

Yared²,

Wang³

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

117

View full text Add to dashboard Cite

show abstract

“…Reported radial strain values in humans using tissue Doppler imaging range from 18 -48% (34,35). Peak radial strain was 39.6 Ϯ 8.9% using PC-MR in the shortaxis view in normal human volunteers (11).…”

Section: Discussionmentioning

confidence: 99%

Persistent decline in longitudinal and radial strain after coronary microembolization detected on velocity encoded phase contrast magnetic resonance imaging

Dicks

Carlsson

Heiberg

et al. 2009

Magnetic Resonance Imaging

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Purpose:To use velocity-encoded phase contrast (PC) MRI in assessing the effect of coronary microembolization on longitudinal and radial myocardial strain. Materials and Methods:A combined X-ray and MR system (XMR) was used for selective left anterior descending artery catheterization and microinfarct assessment in swine (n ϭ 6). The embolized area at risk was defined on perfusion MRI followed by administration of a 7500 count (size ϭ 100 -300 m) of the embolic agent. Quantification of strain and microinfarction was performed at 1 h and 1 week using PC-MRI and delayed enhancement (DE) MRI, respectively. At postmortem, sliced hearts were stained to define microinfarction.Results: Baseline longitudinal and radial strain did not differ between area-at-risk and remote myocardium. The embolized territory (area at risk) showed significant decline in longitudinal strain from Ϫ11.5 Ϯ 3.2% to 1.8 Ϯ 2.5% at 1 h (P Ͻ 0.05) and Ϫ3.9 Ϯ 1.1% at 1 week (P Ͻ 0.05). Similarly, regional radial strain progressively declined from 23.6 Ϯ 2.5% at baseline to 12.5 Ϯ 3.7% at 1 h (P Ͻ 0.05) and 4.8 Ϯ 5.0% at 1 week (P Ͻ 0.01). The size of microinfarction was not significantly different between DE-MRI and histochemical staining. Conclusion:PC-MRI is sensitive in assessing changes in regional longitudinal and radial strain after coronary embolization. Longitudinal and radial strain of the hyperenhanced patchy microinfarction demonstrates persistent decline over the course of 1 week.

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“…30 A meta-analysis comparing DES vs BMS for saphenous grafts showed a lower incidence of major adverse cardiac events in the DES group over a 6-to 12-month period, mainly due to a reduction in target vessel revascularization. 31 Nevertheless, there is a paucity of data on PCI in grafts, whether in a stable or unstable condition, and few randomized trials of insufficient power and short-term followup.…”

Section: Prognosismentioning

confidence: 99%

Can We Improve Outcomes in Patients With Previous Coronary Artery Bypass Surgery Admitted for Acute Coronary Syndrome?

Teixeira

Lourenço

António

et al. 2010

Revista Española de Cardiología (English Edition)

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Global and Regional Myocardial Function Quantification by Two-Dimensional Strain

Abstract: Two-dimensional strain is a new simple, rapid, and reproducible method to measure different components of systolic strain. This technique identified early abnormalities in patients with HCM that have apparently normal left ventricular systolic function.

Cited by 462 publications

References 16 publications

The impact of endurance exercise training on left ventricular systolic mechanics

The impact of endurance exercise training on left ventricular systolic mechanics

Persistent decline in longitudinal and radial strain after coronary microembolization detected on velocity encoded phase contrast magnetic resonance imaging

Can We Improve Outcomes in Patients With Previous Coronary Artery Bypass Surgery Admitted for Acute Coronary Syndrome?

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