Global and regional evaluation of systolic and distolic left ventricular temporal parameters using a novel program for ECG-gated myocardial perfusion SPECT

Yamamoto, Akira; Takahashi, Naoto; Munakata, Kazuo; Hosoya, Tetsuo; Shiiba, Masato; Okuyama, Takao; Abe, Kazuya; Kaneshiro, Tadashi; Tsuruta, Haruko; Takama, Toshi; Sato, Masashi

doi:10.1007/bf03033989

Cited by 24 publications

(12 citation statements)

References 11 publications

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“…Tissue velocity imaging and speckle tracking radial strain are also relatively new techniques that require a learning curve and hands-on training, because a certain level of experience is essential (53). Strain data are sensitive to the placement of the region of interest and require higher-quality images than the routine optical interpretation (53,54). Mavinkurve et al recently showed that myocardial strain and strain rate were significantly lower in survivors of childhood cancer than in healthy controls (55).…”

Section: Noninvasive Imaging Of Cardiotoxicitymentioning

confidence: 99%

Scintigraphic Techniques for Early Detection of Cancer Treatment–Induced Cardiotoxicity

et al. 2011

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New antitumor agents have resulted in significant survival benefits for cancer patients. However, several agents may have serious cardiovascular side effects. Left ventricular ejection fraction measurement by 99m Tc multigated radionuclide angiography is regarded as the gold standard to measure cardiotoxicity in adult patients. It identifies left ventricular dysfunction with high reproducibility and low interobserver variability. A decrease in left ventricular ejection fraction, however, is a relatively late manifestation of myocardial damage. Nuclear cardiologic techniques that visualize pathophysiologic processes at the tissue level could detect myocardial injury at an earlier stage. These techniques may give the opportunity for timely intervention to prevent further damage and could provide insights into the mechanisms and pathophysiology of cardiotoxicity caused by anticancer agents. This review provides an overview of past, current, and promising newly developed radiopharmaceuticals and describes the role and recent advances of scintigraphic techniques to measure cardiotoxicity. Both first-order functional imaging techniques (visualizing mechanical [pump] function), such as 99m Tc multigated radionuclide angiography and 99m Tc gated blood-pool SPECT, and third-order functional imaging techniques (visualizing pathophysiologic and neurophysiologic processes at the tissue level) are discussed. Third-order functional imaging techniques comprise 123 I-metaiodobenzylguanidine scintigraphy, which images the efferent sympathetic nervous innervations; sympathetic neuronal PET, with its wide range of tracers; 111 In-antimyosin, which is a specific marker for myocardial cell injury and necrosis; 99m Tc-annexin V scintigraphy, which visualizes apoptosis and cell death; fatty-acid-use scintigraphy, which visualizes the storage of free fatty acids in the lipid pool of the cytosol (which can be impaired by cardiotoxic agents); and 111 In-trastuzumab imaging, to study trastuzumab targeting to the myocardium. To define the prognostic importance and clinical value of each of these functional imaging techniques, prospective clinical trials are warranted.

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Section: Noninvasive Imaging Of Cardiotoxicitymentioning

confidence: 99%

Scintigraphic Techniques for Early Detection of Cancer Treatment–Induced Cardiotoxicity

et al. 2011

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“…We have validated the systolic/diastolic temporal indices obtained by cardioGRAF by comparing them with those obtained by ERNA and STI. 24 With regard to the systolic synchronous indices, MD-TES and MD-TPE in the G-C subjects were not different from those obtained from G-1 patients (Figs 6A,B). By contrast, the diastolic synchronous indices, MD-TPF1 and MD-TPF2 were significantly smaller in G-C subjects than in G-1 patients (Figs 6C,D).…”

Section: Systolic and Diastolic Dyssynchronymentioning

confidence: 61%

Assessment of Left Ventricular Dyssynchrony During Development of Heart Failure by a Novel Program Using ECG-Gated Myocardial Perfusion SPECT

Takahashi

Yamamoto

Tezuka

et al. 2008

Circ J

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Background A novel program, "cardioGRAF", has been developed to analyze regional left ventricular (LV) systolic/diastolic function and dyssynchrony, so the present study aimed to use it confirm the presence of LV dyssynchrony, and to correlate LV function and dyssynchrony with plasma B-type natriuretic peptide (BNP) levels during the early to advanced stages of heart failure (HF). Methods and ResultsFourteen control subjects (G-C) and 50 patients (New York Heart Association functional class I: G-1, 21 patients; class II: G-2, 15 patients; and class III: G-3, 14 patients) were examined by ECG-gated myocardial perfusion single-photon emission computed tomography, using the new index of dyssynchrony, maximal difference (MD), which is the difference between the earliest and latest temporal parameters among 17 segments. First-third filling rate (FR) and the MD of time to peak FR revealing diastolic dyssynchrony were significantly different between G-C subjects and G-1 patients. Ejection fraction, peak ejection rate, peak FR, MD of time to end-systole, and MD of time to peak ejection rate were significantly correlated with plasma BNP levels. Conclusion Diastolic dyssynchrony was demonstrated even in the early stage of HF, but, although not correlated with the plasma BNP level, systolic dyssynchrony might affect it. (Circ J 2008; 72: 370 -377)

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“…We have developed the new GMPS analyzing program to evaluate LV functional and temporal parameters globally and regionally. It has been validated in previous studies [7,8].…”

Section: Discussionmentioning

confidence: 91%

“…We developed GMPS analyzing program which evaluates not only global (g-) but also regional (r-) functional and temporal parameters including TPF [7,8]. It facilitates estimation of regional diastolic impairment by the elongation of r-TPF.…”

Section: Introductionmentioning

confidence: 99%

Relationships among regional diastolic impairment, elongation of global time to peak filling rate, and global diastolic function using ECG-gated myocardial perfusion SPECT in heart failure

et al. 2007

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Global and regional evaluation of systolic and distolic left ventricular temporal parameters using a novel program for ECG-gated myocardial perfusion SPECT

Abstract: The feasibility of evaluating systolic and diastolic temporal parameters by a new program was validated. This program has the potential to evaluate both diastolic and systolic heterogeneous wall motions which express dyssynchrony in heart failure.

Cited by 24 publications

References 11 publications

Scintigraphic Techniques for Early Detection of Cancer Treatment–Induced Cardiotoxicity

Scintigraphic Techniques for Early Detection of Cancer Treatment–Induced Cardiotoxicity

Assessment of Left Ventricular Dyssynchrony During Development of Heart Failure by a Novel Program Using ECG-Gated Myocardial Perfusion SPECT

Relationships among regional diastolic impairment, elongation of global time to peak filling rate, and global diastolic function using ECG-gated myocardial perfusion SPECT in heart failure

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