Global and regional dissemination and evolution of Burkholderia pseudomallei

Chewapreecha, Claire; Holden, Matthew T. G.; Vehkala, Minna; Välimäki, Niko; Yang, Zhirong; Harris, Simon R.; Mather, Alison E.; Tuanyok, Apichai; Smet, Birgit De; Hello, Simon Le; Bizet, Chantal; Mayo, Mark; Wuthiekanun, Vanaporn; Limmathurotsakul, Direk; Phetsouvanh, Rattanaphone; Spratt, Brian G.; Corander, Jukka; Keim, Paul; Dougan, Gordon; Dance, David A. B.; Currie, Bart J.; Parkhill, Julian; Peacock, Sharon J.

doi:10.1038/nmicrobiol.2016.263

Cited by 137 publications

(190 citation statements)

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“…Analysis of SNPs in whole-genome sequences appears quite promising as a way to correlate isolates with geographic origin ( 4 , 10 , 11 ). The ability to link a strain with a geographic origin has been shown to be increasingly useful, especially in areas such as the US mainland, which so far does not appear to be endemic for melioidosis ( 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…Subsequent studies by Sarovich et al ( 10 ) and Chewapreecha et al ( 11 ) added support to this hypothesis by inferring relatedness from whole-genome SNPs. These studies indicate that Southeast Asia was the source of isolates from Africa, and Africa then became the source for B. pseudomallei in the Western Hemisphere, potentially associated with transfer to the Americas by the slave trade ( 10 , 11 ).…”

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confidence: 98%

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Phylogeography ofBurkholderia pseudomalleiIsolates, Western Hemisphere

Gee¹,

Gulvik²,

Elrod³

et al. 2017

Emerg. Infect. Dis.

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The bacterium Burkholderia pseudomallei causes melioidosis, which is mainly associated with tropical areas. We analyzed single-nucleotide polymorphisms (SNPs) among genome sequences from isolates of B. pseudomallei that originated in the Western Hemisphere by comparing them with genome sequences of isolates that originated in the Eastern Hemisphere. Analysis indicated that isolates from the Western Hemisphere form a distinct clade, which supports the hypothesis that these isolates were derived from a constricted seeding event from Africa. Subclades have been resolved that are associated with specific regions within the Western Hemisphere and suggest that isolates might be correlated geographically with cases of melioidosis. One isolate associated with a former World War II prisoner of war was believed to represent illness 62 years after exposure in Southeast Asia. However, analysis suggested the isolate originated in Central or South America.

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Section: Discussionmentioning

confidence: 99%

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confidence: 98%

Phylogeography ofBurkholderia pseudomalleiIsolates, Western Hemisphere

Gee¹,

Gulvik²,

Elrod³

et al. 2017

Emerg. Infect. Dis.

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“…A subsequent study evaluating the dissemination and evolution of B. pseudomallei has identified distinct evolutionary bacterial lineages after sequencing and comparing more than 250 B. pseudomallei strains isolated between 1935 and 2013 from humans with melioidosis or environmental samples, and representing countries across Australia, Asia, Africa and Central and South America [17]. This genomic global analysis confirmed that the Australian continent represents an early reservoir for B. pseudomallei , with the bacteria being first transmitted to southeast Asia with subsequent dissemination to South and East Asia [17]. Further, the study also confirmed that B. pseudomallei isolates from African origin were transmitted to Central and South America between 1650 and 1850, which correspond to the period representing the slave trade.…”

Section: Predicted and Evidenced Global Incidence Of Diseasementioning

confidence: 99%

Novel multi-component vaccine approaches for Burkholderia pseudomallei

Morici

Torres

Titball

2019

Clinical and Experimental Immunology

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Burkholderia pseudomallei is the causative agent of melioidosis. Historically believed to be a relatively rare human disease in tropical countries, a recent study estimated that, worldwide, there are approximately 165 000 human melioidosis cases per year, more than half of whom die. The bacterium is inherently resistant to many antibiotics and treatment of the disease is often protracted and ineffective. There is no licensed vaccine against melioidosis, but a vaccine is predicted to be of value if used in high-risk populations. There has been progress over the last decade in the pursuit of an effective vaccine against melioidosis. Animal models of disease including mouse and non-human primates have been developed, and these models show that antibody responses play a key role in protection against melioidosis. Surprisingly, although B. pseudomallei is an intracellular pathogen there is limited evidence that CD8 + T cells play a role in protection. It is evident that a multi-component vaccine, incorporating one or more protective antigens, will probably be essential for protection because of the pathogen's sophisticated virulence mechanisms as well as strain heterogeneity. Multi-component vaccines in development include glycoconjugates, multivalent subunit preparations, outer membrane vesicles and other nano/microparticle platforms and live-attenuated or inactivated bacteria. A consistent finding with vaccine candidates tested in mice is the ability to induce sterilizing immunity at low challenge doses and extended time to death at higher challenge doses. Further research to identify ways of eliciting more potent immune responses might provide a path for licensing an effective vaccine.

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“…The transmission dynamics of a Burkholderia dolosa 523 CF outbreak was tracked in 14 patients over 16 years and identified mutations in the 112 524 isolates that showed parallel evolution towards increased antibiotic resistance and tolerance 525 of low oxygen (Lieberman et al 2011). The cause of melioidosis, Burkholderia pseudomallei, 526 has been subjected to arguably the most extensive genomic characterisation because of its 527 pathogenicity and due to its threat as a bioterrorism agent (Chewapreecha et al 2017). The presence of subinhibitory concentrations of trimethoprim (1 µg/ml) reduced the production of bongkrekic acid in strain BCC1678 as shown the HPLC metabolite analysis comparing production levels against the control condition without antibiotic.…”

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confidence: 99%

“…Genome sequencing of 469 B. pseudomallei isolates showed the species comprised two 529 distinct populations, an ancestral Australian reservoir that anthropogenically transmitted and 530 diverged within Asia, and spread further via the slave trade from Africa to South America 531(Chewapreecha et al 2017). Mapping the phylogenomics of B. ambifaria as a historically used 532 biopesticide revealed the BGC for cepacin A, a key antimicrobial mediating plant protection 533 against pathogenic oomycetes(Mullins et al 2019).…”

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confidence: 99%

Kill and cure: genomic phylogeny and bioactivity of a diverse collection ofBurkholderia gladiolibacteria capable of pathogenic and beneficial lifestyles

Webster

Mullins

et al. 2020

Preprint

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55Burkholderia gladioli is one of few bacteria with a broad ecology spanning disease in humans, 56 animals, and plants, and encompassing beneficial interactions with multiple eukaryotic hosts. 57It is a plant pathogen, a bongkrekic acid toxin producing food-poisoning agent, and a lung 58 pathogen in people with cystic fibrosis (CF). Contrasting beneficial traits include antifungal 59 production exploited by insects to protect their eggs, plant protective abilities and antibiotic 60 biosynthesis. We explored the ecological diversity and specialized metabolite biosynthesis of 61 206 B. gladioli strains, phylogenomically defining 5 evolutionary clades. Historical disease 62 pathovars (pv) B. gladioli pv. allicola and B. gladioli pv. cocovenenans were phylogenetically 63 distinct, while B. gladioli pv. gladioli and B. gladioli pv. agaricicola were indistinguishable. Soft-64 rot disease and CF infection pathogenicity traits were conserved across all pathovars. 65Biosynthetic gene clusters for toxoflavin, caryoynencin and enacyloxin were dispersed across 66 B. gladioli, but bongkrekic acid and gladiolin production were clade specific. Strikingly, 13% of 67 CF-infection strains characterised (n=194) were bongkrekic acid toxin positive, uniquely 68 linking this food-poisoning risk factor to chronic lung disease. Toxin production was 69 suppressed by exposing strains to the antibiotic trimethoprim, providing a potential therapeutic 70 strategy to minimise poisoning risk in CF. 71 72

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Global and regional dissemination and evolution of Burkholderia pseudomallei

Abstract: *Correspondence should be addressed to Claire Chewapreecha (cchewapreecha@gmail.com) and Sharon Peacock (sharon.peacock@lshtm.ac.uk). § Deceased.

Cited by 137 publications

References 54 publications

Phylogeography ofBurkholderia pseudomalleiIsolates, Western Hemisphere

Phylogeography ofBurkholderia pseudomalleiIsolates, Western Hemisphere

Novel multi-component vaccine approaches for Burkholderia pseudomallei

Kill and cure: genomic phylogeny and bioactivity of a diverse collection ofBurkholderia gladiolibacteria capable of pathogenic and beneficial lifestyles

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