“…Several cross-sectional (Fjell, et al, 2009, Fjell, et al, 2013, Marcus, et al, 2007, Schippling, et al, 2017, Ziegler, et al, 2012, as well as longitudinal studies (Driscoll, et al, 2009, Hedman, et al, 2012, Marcus, et al, 2010, Taki, et al, 2011, found that BVL critically depends on age, in both, MS patients and healthy individuals. A recent study reported age dependent mean BVL per year values in physiological aging (Schippling, et al, 2017). However, the data in that study were extrapolated from cross-sectional brain volumetry data using a non-parametric fitting approach.…”