Global and local environmental changes as drivers of Buruli ulcer emergence

Combe, Marine; Velvin, Camilla Jensen; Morris, Aaron H.; Garchitorena, Andrés; Carolan, Kevin; Sanhueza, Daniel; Roche, Benjamín; Couppié, Pierre; Guégan, Jean‐François; Gozlan, Rodolphe E.

doi:10.1038/emi.2017.45

Cited by 8 publications

(18 citation statements)

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“…It has long been thought that the transmission of MU from a freshwater environment to ‘dead‐end’ human hosts most likely occurs from contact with traumatized skin 1,2 . The variability in BU incidence and severity between countries have driven the scientific community to focus on the diversity of MU strains and mycolactone types 1 . Here, we looked at BU cases for the potential presence of co‐infections from several mycobacteria or infections from mycobacteria species other than MU, which could explain the observed BU variability.…”

Section: No Date Of Diagnosis Clinical Aspect Of the Skin Lesion Is2mentioning

confidence: 99%

Are all Buruli ulcers caused by Mycobacterium ulcerans ?

et al. 2020

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normal functioning (Quality of life). People with LS reported problems with dyspareunia, physical inability to engage in intercourse due to narrowing of the vaginal opening, and lack of sexual drive from loss of sensation. They referred to the emotional impact on relationships as well as their own psychosocial-sexual wellbeing (Sexual dysfunction). Responses placed greater significance on the changes related to anatomical structure (229 responses) than on variations in cosmetic appearance (70 responses) (Appearance). Many participants described fear of potential progression to malignancy and irreversible stenosis (Progression of the condition). The importance of better awareness of LS among the general public and doctors was highlighted to aid earlier diagnosis and prevention of scarring. Many patients called for treatment that quickly resolves symptoms, reduces flare-ups and is easier to use than the standard first-line therapy of topical steroids (Management of the condition). The six key themes/domains identified above will inform the first stage of development for a LS core outcome set through the CORALS (Core Outcomes for ReseArch in LS) initiative. 8 The first stage will obtain international consensus on core outcome domains via an electronic-Delphi exercise. Subsequent work to identify appropriate outcome measurement instruments will then be needed to use in the final core outcome set. Although CORALS is intended for use in randomized trials, we believe that understanding these outcomes of importance is valuable for managing LS in the outpatient clinic. Ensuring that these issues are addressed during the consultation will benefit patient experience and overall quality of care.

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Section: No Date Of Diagnosis Clinical Aspect Of the Skin Lesion Is2mentioning

confidence: 99%

Are all Buruli ulcers caused by Mycobacterium ulcerans ?

et al. 2020

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“…Complications can include severe scarring and limb contractures. Notably, there is a close relationship between rainfall patterns and Buruli ulcer, with increased diagnoses after periods of heavy rainfall ( Combe et al, 2017 ). Children age 5 to 15 years are most affected in both incidence and severity in endemic countries of West Africa ( Yotsu et al, 2015 ; see Bandino’s “An expanding abscess after a flooding disaster” in this issue).…”

Section: Climate Refugees Infections and Infestationsmentioning

confidence: 99%

Climate change and pediatric skin health

Schachtel

Dyer

Boos

2021

International Journal of Women's Dermatology

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Children are known to disproportionately bear the health impacts of climate change, particularly children living in impoverished areas. Owing to their developing physiology and immature metabolism, distinct exposure behaviors, and reliance on adults for care and protection, children are uniquely susceptible to the adverse effects of our warming planet. Herein, we summarize the known impacts of climate change on pediatric skin health, including its effects on atopic dermatitis, vector-borne and other infectious diseases, nutritional deficiencies, and psychodermatoses.

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“…Additionally, in nearby areas with no cases of human disease possum faeces were not found to contain M. ulcerans DNA [47]. It is theoretically possible that infected possums amplify the organism in the environment [93], leading to an increased risk of infection via contact with a contaminated environment, or an intermediate vector such as a mosquito could mechanically transmit the bacteria from infected possums to humans via a bite. Further research is required to investigate these potential transmission mechanisms and determine if possums play a pivotal role in the transmission of disease to humans or whether they are simply accidental hosts.…”

Section: Transmission Of Bu To Humansmentioning

confidence: 99%

“…The epidemiology of M. ulcerans has clearly changed over time and is expected to continue evolving into the future. Although the explanations for this are not fully understood, the processes associated with increasing anthropogenic land-use change such as deforestation, road construction, flooding and population settlement may have significant impacts on this environmental pathogen, affecting both its future distribution and human exposure risk [93]. For example, the increase in cases in recent years observed in south-eastern Victoria, Australia, may be reflective of the impact of new residential developments which may have altered the environment and impacted both aquatic and terrestrial communities, including a proposed reservoir of M. ulcerans , the possum.…”

Section: Future Prospectsmentioning

confidence: 99%

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The changing epidemiology worldwide ofMycobacterium ulcerans

et al. 2018

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Mycobacterium ulceransis recognised as the third most common mycobacterial infection worldwide. It causes necrotising infections of skin and soft tissue and is classified as a neglected tropical disease by the World Health Organization (WHO). However, despite extensive research, the environmental reservoir of the organism and mode of transmission of the infection to humans remain unknown. This limits the ability to design and implement public health interventions to effectively and consistently prevent the spread and reduce the incidence of this disease. In recent years, the epidemiology of the disease has changed. In most endemic regions of the world, the number of cases reported to the WHO are reducing, with a 64% reduction in cases reported worldwide in the last 9 years. Conversely, in a smaller number of countries including Australia and Nigeria, reported cases are increasing at a rapid rate, new endemic areas continue to appear, and in Australia cases are becoming more severe. The reasons for this changing epidemiology are unknown. We review the epidemiology ofM. ulceransdisease worldwide, and document recent changes. We also outline and discuss the current state of knowledge on the ecology ofM. ulcerans, possible transmission mechanisms to humans and what may be enabling the spread ofM. ulceransinto new endemic areas.

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Global and local environmental changes as drivers of Buruli ulcer emergence

Cited by 8 publications

References 0 publications

Are all Buruli ulcers caused by Mycobacterium ulcerans ?

Are all Buruli ulcers caused by Mycobacterium ulcerans ?

Climate change and pediatric skin health

The changing epidemiology worldwide ofMycobacterium ulcerans

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