Global Aging and Cancer: Advancing Care Through Innovation

Abstract

The oncology field, like many others, is digitalizing rapidly, a phenomenon that may have been accelerated by the COVID-19 pandemic. This movement is creating opportunities and challenges. Another rapidly developing change is the aging of the global population; because cancer is a disease of aging, there is a need for health systems to adapt to taking care of such patients. In this article, we address how these innovative technologies can be leveraged to improve the care of older patients with cancer beyond academic centers, such as in underserved areas and low- and middle-income countries. We review how digital technologies can be used to enhance the follow-up of patients in low- and middle-income countries. We also tackle the issue of training a global workforce to treat cancer in an aging population and how to leverage innovations in this matter. Finally, we review opportunities to expand the usefulness of big data and machine learning beyond academic centers to support private practices and underserved areas.

Identification and Development of an Age-Related Classification and Signature to Predict Prognosis and Immune Landscape in Osteosarcoma

“…This process also causes the removal of these damaged cells by activating the immune system through the SASP, but if the cells evade this fate, it may lead to tumorigenesis [ 34 ]. Emerging evidence showed that several ARGs may be the cause of onset and advancement of cancers due to regulation of the process of aging and cellular senescence by these ARGs and could be used as a target for cancer therapy [ 35 , 36 ]. Consequently, to analyze the exact role that aging plays in osteosarcoma, the transcriptome of the ARGs needs to be investigated thoroughly.…”

Geriatric Breast Cancer: Staging, Molecular Surrogates, and Treatment. A Review & Meta-analysis

“…Discussions about advantages and hazards, tailored to each woman's health situation, are essential for optimizing screening procedures [ 9 ]. Once cancer is a disease of aging, health systems need to adapt healthcare to such patients [ 19 ]. When treating BC in older women, it is vital to strike a balance between the treatment's curative purpose and the patient's comorbidities and quality of life [ 20 ] Patients in their later years have a decreased life expectancy and a different kind of longevity advantage.…”